{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:28:23Z","timestamp":1787077703830,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>This study evaluated the ability of the ABC Bicuspid Sizing Algorithm to predict aortic root rupture in patients treated with transcatheter aortic valve replacement using SAPIEN 3 valves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective multicenter study among 15 centers in 7 countries of aortic root rupture cases and controls without root complications. Computed tomography analysis was performed blinded to rupture status. The ABC algorithm was applied to classify risk (high-risk criteria): (1) annular oversizing &gt;10%, (2) intercommissural distance \u2212 valve diameter \u22641 mm, (3) maximum sinus diameter \u2212 valve diameter &lt;6 mm alone, or (4) maximum sinus diameter \u2212 valve diameter 6 to 8 mm with contrast calcium volume &gt;1000 mm\n                      <jats:sup>3<\/jats:sup>\n                      and raphe + contralateral or ipsilateral leaflet calcium volume &gt;800 mm\n                      <jats:sup>3<\/jats:sup>\n                      , (5) protruding nodular intercommissural distance calcium or full-length calcification of both leaflet edges.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 170 patients were included (23 ruptures and 147 controls). Cases exhibited higher total calcium volume (median: 1498 mm\n                      <jats:sup>3<\/jats:sup>\n                      versus 826 mm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), smaller intercommissural distance difference (median: \u22120.15 versus 1.19 mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.009), smaller maximum sinus difference (median: 6.79 versus 9.19 mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and greater annular oversizing (median: 6.57% versus 3.51%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.047). The presence of any high-risk criterion had a sensitivity of 100% (95% CI, 85.7%\u2013100%) and a specificity of 89.1% (95% CI, 83.1%\u201393.2%) for the identification of rupture cases. The diagnostic odds ratio was 374.5 (95% CI, 21.7\u20136459.9), with a positive likelihood ratio of 9.19 and a negative likelihood ratio of 0.023.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>High calcium volume, narrow sinus dimensions, and excessive valve oversizing were associated with aortic root rupture. The ABC algorithm showed promising performance for risk stratification of patients with bicuspid anatomy being considered for treatment with a SAPIEN 3 valve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.126.016918","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T18:15:12Z","timestamp":1782411312000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Aortic Root Rupture in Bicuspid Aortic Stenosis: The ABC Sizing Algorithm for SAPIEN 3 Valves"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4651-8310","authenticated-orcid":true,"given":"Tej","family":"Sheth","sequence":"first","affiliation":[{"name":"Division of Cardiology, Hamilton Health Sciences and McMaster University, Canada (T.S., J.V., M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-7095","authenticated-orcid":true,"given":"Josep","family":"Rod\u00e9s-Cabau","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Institute (IUCPQ), Laval University, Quebec City, Canada (J.R.-C., J.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Poon","sequence":"additional","affiliation":[{"name":"St Andrew\u2019s War Memorial Hospital, Brisbane and University of Queensland, Australia (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3428-617X","authenticated-orcid":true,"given":"Jean Michel","family":"Paradis","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Institute (IUCPQ), Laval University, Quebec City, Canada (J.R.-C., J.M.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Fam","sequence":"additional","affiliation":[{"name":"Unity Health, University of Toronto, Canada (N.F., S.A.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale","family":"Murdoch","sequence":"additional","affiliation":[{"name":"The Prince Charles Hospital, Brisbane, and University of Queensland, Australia (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Al-Nasser","sequence":"additional","affiliation":[{"name":"Unity Health, University of Toronto, Canada (N.F., S.A.-N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-4103","authenticated-orcid":true,"given":"Mann","family":"Chandavimol","sequence":"additional","affiliation":[{"name":"Bangkok Heart Hospital\/Ramathibodi Hospital, Thailand (M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Chavarria","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios\/Hospital Cl\u00ednica B\u00edblica, San Jos\u00e9, Costa Rica (J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Dick","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute, Canada (A.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8150-0477","authenticated-orcid":true,"given":"Anna","family":"Bizios","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute\/Foothills Medical Centre, University of Calgary, Canada (A.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-3109","authenticated-orcid":true,"given":"Pantelis","family":"Diamantouros","sequence":"additional","affiliation":[{"name":"London Health Sciences Centre (LHSC), Western University, Ontario, Canada (P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Yap","sequence":"additional","affiliation":[{"name":"National Heart Centre Singapore (J.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Chatfield","sequence":"additional","affiliation":[{"name":"Wellington Regional Hospital\/Wakefield Heart Centre, New Zealand (A.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul-Rahman","family":"Ihdayhid","sequence":"additional","affiliation":[{"name":"Fiona Stanley Hospital\/Harry Perkins Institute of Medical Research, Perth, Australia (A.-R.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonny","family":"Palmer","sequence":"additional","affiliation":[{"name":"The Alfred Hospital, Melbourne, Australia (S. Palmer)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Said Vega","sequence":"additional","affiliation":[{"name":"National Institute of Cardiology Ignacio Chavez, Mexico City, Mexico (N.S.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-3701","authenticated-orcid":true,"given":"James","family":"Velianou","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hamilton Health Sciences and McMaster University, Canada (T.S., J.V., M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9407-5622","authenticated-orcid":true,"given":"Sameer","family":"Parpia","sequence":"additional","affiliation":[{"name":"Department of Statistics, McMaster University, Hamilton, Canada (S. Parpia)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2283-5474","authenticated-orcid":true,"given":"Muhammad","family":"Suleman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hamilton Health Sciences and McMaster University, Canada (T.S., J.V., M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13346"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2020.01.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-23-00021"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suac014"},{"key":"e_1_3_3_6_2","first-page":"41","article-title":"Circle method for bicuspid screening.","volume":"15","author":"Kempfert J","year":"2021","unstructured":"Kempfert J, Fusari M. Circle method for bicuspid screening. Cardiac Interventions Today. 2021;15:41\u201344. https:\/\/citoday.com\/articles\/2021-sept-oct\/circle-method-for-bicuspid-screening","journal-title":"Cardiac Interventions Today"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.shj.2025.100487"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.07.020"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.07.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007107"},{"key":"e_1_3_3_11_2","unstructured":"Sheth T. ABCSizing. Version 1.0.4. Tej Sheth; 2025. Accessed January 31 2026. https:\/\/apps.apple.com\/gb\/app\/abcsizing\/id6740382420"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.31091"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.126.016918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:00:33Z","timestamp":1787076033000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.126.016918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.126.016918"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.126.016918","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}