{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:35:19Z","timestamp":1792805719419,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:sec><jats:title>Background\u2014<\/jats:title><jats:p>Reduced heart rate variability (HRV), a measure of cardiac autonomic dysfunction, is a risk factor for coronary artery disease. Diet can influence HRV, but this association may be confounded by genetic and environmental factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results\u2014<\/jats:title><jats:p>We administered the Willett Food Frequency Questionnaire to 276 middle-aged male twins. We derived a score measuring the extent to which an individual's diet conformed to the Mediterranean diet following a published algorithm. The higher the score, the greater the similarity to the Mediterranean diet. All twins underwent 24-hour ambulatory ECG recording. Time and frequency domain measures of HRV were calculated. Mixed-effects regression was used to partition the association into between- and within-twin pair differences. After adjusting for energy intake, other nutritional factors, shared genes, and common environment, a 1-unit higher score was significantly associated with 3.9% to 13% higher time and frequency domain HRV parameters. Further controlling for known cardiovascular risk factors and use of fish oil supplements and medications did not substantially change the estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\u2014<\/jats:title><jats:p>The Mediterranean dietary pattern is associated with higher HRV.<\/jats:p><\/jats:sec>","DOI":"10.1161\/circoutcomes.109.905810","type":"journal-article","created":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T03:03:43Z","timestamp":1276657423000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":45,"title":["Mediterranean Dietary Pattern Is Associated With Improved Cardiac Autonomic Function Among Middle-Aged Men"],"prefix":"10.1161","volume":"3","author":[{"given":"Jun","family":"Dai","sequence":"first","affiliation":[{"name":"From the Department of Applied Health Science (J.D.), School of Health, Physical Education, and Recreation, Indiana University, Bloomington, Ind; Indiana Center for Vascular Biology and Medicine (J.D.), Indianapolis, Ind; the Section of Cardiovascular Medicine (R.L.), Yale University School of Medicine, New Haven, Conn; the Department of Medicine (P.W.W., V.V.), Division of Cardiology, Emory Program in Cardiovascular Outcomes Research and Epidemiology (EPICORE), Emory University School of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Lampert","sequence":"additional","affiliation":[{"name":"From the Department of Applied Health Science (J.D.), School of Health, Physical Education, and Recreation, Indiana University, Bloomington, Ind; Indiana Center for Vascular Biology and Medicine (J.D.), Indianapolis, Ind; the Section of Cardiovascular Medicine (R.L.), Yale University School of Medicine, New Haven, Conn; the Department of Medicine (P.W.W., V.V.), Division of Cardiology, Emory Program in Cardiovascular Outcomes Research and Epidemiology (EPICORE), Emory University School of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter W.","family":"Wilson","sequence":"additional","affiliation":[{"name":"From the Department of Applied Health Science (J.D.), School of Health, Physical Education, and Recreation, Indiana University, Bloomington, Ind; Indiana Center for Vascular Biology and Medicine (J.D.), Indianapolis, Ind; the Section of Cardiovascular Medicine (R.L.), Yale University School of Medicine, New Haven, Conn; the Department of Medicine (P.W.W., V.V.), Division of Cardiology, Emory Program in Cardiovascular Outcomes Research and Epidemiology (EPICORE), Emory University School of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Goldberg","sequence":"additional","affiliation":[{"name":"From the Department of Applied Health Science (J.D.), School of Health, Physical Education, and Recreation, Indiana University, Bloomington, Ind; Indiana Center for Vascular Biology and Medicine (J.D.), Indianapolis, Ind; the Section of Cardiovascular Medicine (R.L.), Yale University School of Medicine, New Haven, Conn; the Department of Medicine (P.W.W., V.V.), Division of Cardiology, Emory Program in Cardiovascular Outcomes Research and Epidemiology (EPICORE), Emory University School of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Ziegler","sequence":"additional","affiliation":[{"name":"From the Department of Applied Health Science (J.D.), School of Health, Physical Education, and Recreation, Indiana University, Bloomington, Ind; Indiana Center for Vascular Biology and Medicine (J.D.), Indianapolis, Ind; the Section of Cardiovascular Medicine (R.L.), Yale University School of Medicine, New Haven, Conn; the Department of Medicine (P.W.W., V.V.), Division of Cardiology, Emory Program in Cardiovascular Outcomes Research and Epidemiology (EPICORE), Emory University School of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Vaccarino","sequence":"additional","affiliation":[{"name":"From the Department of Applied Health Science (J.D.), School of Health, Physical Education, and Recreation, Indiana University, Bloomington, Ind; Indiana Center for Vascular Biology and Medicine (J.D.), Indianapolis, Ind; the Section of Cardiovascular Medicine (R.L.), Yale University School of Medicine, New Haven, Conn; the Department of Medicine (P.W.W., V.V.), Division of Cardiology, Emory Program in Cardiovascular Outcomes Research and Epidemiology (EPICORE), Emory University School of Medicine,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.22.2461"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.816736"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025039"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.7.1879"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26849"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.732826"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.5.651"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508959225"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2004.09.005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6166045"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.038"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.6.547"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.85.1.164"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.11.2850"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(93)90106-B"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.26.061505.111218"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/cki167"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31817bcc9e"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.710699"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.3945\/ajcn.2008.26528","article-title":"Association between adherence to the Mediterranean diet and oxidative stress","volume":"88","author":"Dai J","year":"2008","unstructured":"Dai J, Jones DP, Goldberg J, Ziegler TR, Bostick RM, Wilson PW, Manatunga AK, Shallenberger L, Jones L, Vaccarino V. 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