{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:27:20Z","timestamp":1790602040343,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Despite ongoing efforts to improve the quality of pediatric resuscitation, it remains unknown whether survival in children with in-hospital cardiac arrest has improved.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              Between 2000 and 2009, we identified children (&lt;18 years of age) with an in-hospital cardiac arrest at hospitals with &gt;3 years of participation and &gt;5 cases annually within the national Get With The Guidelines\u2013Resuscitation registry. Multivariable logistic regression was used to examine temporal trends in survival to discharge. We also explored whether trends in survival were attributable to improvement in acute resuscitation or postresuscitation care and examined trends in neurological disability among survivors. Among 1031 children at 12 hospitals, the initial cardiac arrest rhythm was asystole and pulseless electrical activity in 874 children (84.8%) and ventricular fibrillation and pulseless ventricular tachycardia in 157 children (15.2%), with an increase in cardiac arrests due to pulseless electrical activity over time (\n              <jats:italic>P<\/jats:italic>\n              for trend &lt;0.001). Risk-adjusted rates of survival to discharge increased from 14.3% in 2000 to 43.4% in 2009 (adjusted rate ratio per year, 1.08; 95% confidence interval, 1.01\u20131.16;\n              <jats:italic>P<\/jats:italic>\n              for trend=0.02). Improvement in survival was driven largely by an improvement in acute resuscitation survival (risk-adjusted rates: 42.9% in 2000, 81.2% in 2009; adjusted rate ratio per year: 1.04; 95% confidence interval, 1.01\u20131.08;\n              <jats:italic>P<\/jats:italic>\n              for trend=0.006). Moreover, survival trends were not accompanied by higher rates of neurological disability among survivors over time (unadjusted\n              <jats:italic>P<\/jats:italic>\n              for trend=0.32), suggesting an overall increase in the number of survivors without neurological disability over time.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Rates of survival to hospital discharge in children with in-hospital cardiac arrests have improved over the past decade without higher rates of neurological disability among survivors.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.112.967968","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T04:37:35Z","timestamp":1355891855000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":301,"title":["Survival Trends in Pediatric In-Hospital Cardiac Arrests"],"prefix":"10.1161","volume":"6","author":[{"given":"Saket","family":"Girotra","sequence":"first","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City (S.G.); Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (J.A.S., Y.L., P.S.C.); University of Missouri-Kansas City (J.A.S., P.S.C.); and Department of Anesthesia and Critical Care, Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (R.A.B., V.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City (S.G.); Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (J.A.S., Y.L., P.S.C.); University of Missouri-Kansas City (J.A.S., P.S.C.); and Department of Anesthesia and Critical Care, Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (R.A.B., V.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City (S.G.); Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (J.A.S., Y.L., P.S.C.); University of Missouri-Kansas City (J.A.S., P.S.C.); and Department of Anesthesia and Critical Care, Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (R.A.B., V.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Berg","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City (S.G.); Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (J.A.S., Y.L., P.S.C.); University of Missouri-Kansas City (J.A.S., P.S.C.); and Department of Anesthesia and Critical Care, Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (R.A.B., V.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay M.","family":"Nadkarni","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City (S.G.); Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (J.A.S., Y.L., P.S.C.); University of Missouri-Kansas City (J.A.S., P.S.C.); and Department of Anesthesia and Critical Care, Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (R.A.B., V.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Chan","sequence":"additional","affiliation":[{"name":"From the University of Iowa Hospitals and Clinics, Iowa City (S.G.); Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (J.A.S., Y.L., P.S.C.); University of Missouri-Kansas City (J.A.S., P.S.C.); and Department of Anesthesia and Critical Care, Children\u2019s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (R.A.B., V.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the American Heart Association Get With the Guidelines\u2013Resuscitation Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9572(00)00167-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.200"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.50"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971085"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000208440.66756.C2"},{"key":"e_1_3_3_7_2","first-page":"362","article-title":"Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory inhospital pediatric cardiac arrest: a report from the National Registry of Cardiopulmonary Resuscitation.","volume":"11","author":"Raymond TT","year":"2010","unstructured":"Raymond TT, Cunnyngham CB, Thompson MT, Thomas JA, Dalton HJ, Nadkarni VM; 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