{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:41:13Z","timestamp":1789965673597,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Limited data are available on efficacy, safety, and long-term prognosis after cardiac resynchronization therapy (CRT) in elderly patients. We aimed at evaluating the effect of CRT, device-related adverse events, and long-term outcome after CRT among elderly patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              A total of 798 CRT recipients (208 elderly: age, \u226575 years; 590 nonelderly: age, &lt;75 years) underwent clinical and echocardiographic evaluation at baseline and 6-month follow-up. Elderly patients had similar improvements in clinical symptoms, left ventricular function, and left ventricular reverse remodeling as their counterparts. Similar rates of device-related in-hospital (within 24 hours;\n              <jats:italic>P<\/jats:italic>\n              =0.552), early (within 30 days;\n              <jats:italic>P<\/jats:italic>\n              =0.984), and long-term adverse events (entire follow-up; hazard ratio, 0.90;\n              <jats:italic>P<\/jats:italic>\n              =0.620) were observed between groups. During long-term follow-up (median, 38.6 months; interquartile range, 22.5\u201361.8 months), all-cause mortality rate was significantly higher among the elderly patients. However, the differences in cumulative event rates started after 4 years of follow-up (\n              <jats:italic>P<\/jats:italic>\n              =0.013), and the cause of death was mainly noncardiac (29% in the elderly versus 19% in nonelderly;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Diabetes mellitus (hazard ratio, 2.322;\n              <jats:italic>P<\/jats:italic>\n              =0.019), impaired renal function (hazard ratio, 0.975;\n              <jats:italic>P<\/jats:italic>\n              =0.006), and reduced 6-minute walk distance (hazard ratio, 0.996;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.019) were independently associated with all-cause mortality in elderly patients.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>CRT efficacy and device-related adverse events in elderly patients were comparable with that of nonelderly patients. However, after 4 years of follow-up, elderly patients showed worse survival and the cause of death was mainly noncardiac. Diabetes mellitus, impaired renal function, and reduced 6-minute walk distance were independently associated with all-cause mortality of elderly patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.113.000821","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T05:08:19Z","timestamp":1400044099000},"page":"437-444","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Left Ventricular Reverse Remodeling, Device-Related Adverse Events, and Long-Term Outcome After Cardiac Resynchronization Therapy in the Elderly"],"prefix":"10.1161","volume":"7","author":[{"given":"Ulas","family":"H\u00f6ke","sequence":"first","affiliation":[{"name":"From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (U.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Putter","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (U.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enno T.","family":"Van Der Velde","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (U.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Schalij","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (U.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Delgado","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (U.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J.","family":"Bax","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (U.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Ajmone","family":"Marsan","sequence":"additional","affiliation":[{"name":"From the Departments of Cardiology (U.H., E.T.V.D.V., M.J.S., V.D., J.J.B., N.A.M.) and Medical Statistics and Bioinformatics (H.P.), Leiden University Medical Center, Leiden, The Netherlands; and Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands (U.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e31828124ad"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.119608"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp359"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.027"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303076"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus222"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.11.009"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.01.031"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02011.x"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90582-W"},{"key":"e_1_3_3_16_2","first-page":"919","article-title":"The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure.","volume":"132","author":"Guyatt GH","year":"1985","unstructured":"Guyatt GH, Sullivan MJ, Thompson PJ, Fallen EL, Pugsley SO, Taylor DW, Berman LB. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985;132:919\u2013923.","journal-title":"Can Med Assoc J"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.08.030"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.015024"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eup362"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.65.3.457"},{"key":"e_1_3_3_24_2","unstructured":"Therneau T. A package for survival analysis in S. R package version 2.37-4. 2013. http:\/\/CRAN.R-project.org\/package=survival."},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2712"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-008-9330-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.30"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(01)00298-4"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.642892"}],"container-title":["Circulation: Cardiovascular Quality and Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCOUTCOMES.113.000821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:55:51Z","timestamp":1715568951000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCOUTCOMES.113.000821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1161\/CIRCOUTCOMES.113.000821"],"URL":"https:\/\/doi.org\/10.1161\/circoutcomes.113.000821","relation":{},"ISSN":["1941-7713","1941-7705"],"issn-type":[{"value":"1941-7713","type":"print"},{"value":"1941-7705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"2013-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}