{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:23:17Z","timestamp":1761578597064},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>\n              To explore the effect of ivabradine on angina-related quality of life (QoL) in patients participating in the Study Assessing the Morbidity\u2013Mortality Benefits of the\n              <jats:italic>I<\/jats:italic>\n              <jats:sub>f<\/jats:sub>\n              Inhibitor Ivabradine in Patients with Coronary Artery Disease (SIGNIFY) QoL substudy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>\n              QoL was evaluated in a prespecified subgroup of SIGNIFY patients with angina (Canadian Cardiovascular Society class score, \u22652 at baseline) using the Seattle Angina Questionnaire and a generic visual analogue scale on health status. Data were available for 4187 patients (2084 ivabradine and 2103 placebo). There were improvements in QoL in both treatment groups. The primary outcome of change in physical limitation score at 12 months was 4.56 points for ivabradine versus 3.40 points for placebo (\n              <jats:italic>E<\/jats:italic>\n              , 0.96; 95% confidence interval, \u20130.14 to 2.05;\n              <jats:italic>P<\/jats:italic>\n              =0.085). The ivabradine\u2212placebo difference in physical limitation score was significant at 6 months (\n              <jats:italic>P<\/jats:italic>\n              =0.048). At 12 months, the visual analogue scale and the other Seattle Angina Questionnaire dimensions were higher among ivabradine-treated patients, notably angina frequency (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and disease perception (\n              <jats:italic>P<\/jats:italic>\n              =0.006). Patients with the worst QoL at baseline (ie, those in the lowest tertile of score) had the best improvement in QoL for 12 months, with improvements in physical limitation and a significant reduction in angina frequency (\n              <jats:italic>P<\/jats:italic>\n              =0.034). The effect on QoL was maintained over the study duration, and ivabradine patients had better scores on angina frequency at every visit to 36 months.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Treatment with ivabradine did not affect the primary outcome of change in physical limitation score at 12 months. It did produce consistent improvements in other self-reported QoL parameters related to angina pectoris, notably in terms of angina frequency and disease perception.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration\u2014<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isrctn.com\">http:\/\/www.isrctn.com<\/jats:ext-link>\n              . Unique identifier: ISRCTN61576291.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.115.002091","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T01:10:33Z","timestamp":1450833033000},"page":"31-38","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Quality of Life With Ivabradine in Patients With Angina Pectoris"],"prefix":"10.1161","volume":"9","author":[{"given":"Michal","family":"Tendera","sequence":"first","affiliation":[{"name":"From the 3rd Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (M.T.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, LEA 7334 (REMES) Patient-Centered Outcomes Research, Paris, France (O.C.); AP-HP, Unit\u00e9 de Recherche Clinique en \u00e9conomie de la Sant\u00e9, H\u00f4pital H\u00f4tel-Dieu, Paris, France (O.C.); Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini: Health..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Chassany","sequence":"additional","affiliation":[{"name":"From the 3rd Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (M.T.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, LEA 7334 (REMES) Patient-Centered Outcomes Research, Paris, France (O.C.); AP-HP, Unit\u00e9 de Recherche Clinique en \u00e9conomie de la Sant\u00e9, H\u00f4pital H\u00f4tel-Dieu, Paris, France (O.C.); Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini: Health..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Ferrari","sequence":"additional","affiliation":[{"name":"From the 3rd Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (M.T.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, LEA 7334 (REMES) Patient-Centered Outcomes Research, Paris, France (O.C.); AP-HP, Unit\u00e9 de Recherche Clinique en \u00e9conomie de la Sant\u00e9, H\u00f4pital H\u00f4tel-Dieu, Paris, France (O.C.); Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini: Health..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Ford","sequence":"additional","affiliation":[{"name":"From the 3rd Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (M.T.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, LEA 7334 (REMES) Patient-Centered Outcomes Research, Paris, France (O.C.); AP-HP, Unit\u00e9 de Recherche Clinique en \u00e9conomie de la Sant\u00e9, H\u00f4pital H\u00f4tel-Dieu, Paris, France (O.C.); Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini: Health..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe Gabriel","family":"Steg","sequence":"additional","affiliation":[{"name":"From the 3rd Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (M.T.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, LEA 7334 (REMES) Patient-Centered Outcomes Research, Paris, France (O.C.); AP-HP, Unit\u00e9 de Recherche Clinique en \u00e9conomie de la Sant\u00e9, H\u00f4pital H\u00f4tel-Dieu, Paris, France (O.C.); Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini: Health..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[{"name":"From the 3rd Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (M.T.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, LEA 7334 (REMES) Patient-Centered Outcomes Research, Paris, France (O.C.); AP-HP, Unit\u00e9 de Recherche Clinique en \u00e9conomie de la Sant\u00e9, H\u00f4pital H\u00f4tel-Dieu, Paris, France (O.C.); Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini: Health..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Fox","sequence":"additional","affiliation":[{"name":"From the 3rd Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland (M.T.); Universit\u00e9 Paris-Diderot, Sorbonne-Paris Cit\u00e9, LEA 7334 (REMES) Patient-Centered Outcomes Research, Paris, France (O.C.); AP-HP, Unit\u00e9 de Recherche Clinique en \u00e9conomie de la Sant\u00e9, H\u00f4pital H\u00f4tel-Dieu, Paris, France (O.C.); Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care and Research, Ettore Sansavini: Health..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.2.140"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000020688.24874.90"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht296"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406430"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.06.024"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00397-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182949a2e"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072771"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr343"},{"key":"e_1_3_3_12_2","first-page":"74","article-title":"LINCOR: results of observational program in patients with myocardial infarction.","volume":"5","author":"Glezer M.","year":"2013","unstructured":"Glezer M. 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