{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:48:47Z","timestamp":1790668127962,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n            <jats:title>Background\u2014<\/jats:title>\n            <jats:p>Epidemiology and consequences of surgery in patients with coronary stents are not clearly defined, as well as the impact of different stent types in relationship with timing of surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results\u2014<\/jats:title>\n            <jats:p>Among 39 362 patients with previous coronary stenting enrolled in a multicenter prospective registry and followed for 5 years, 13 128 patients underwent 17 226 surgical procedures. The cumulative incidence of surgery at 30 days, 6 months, 1 year, and 5 years was 3.6%, 9.4%, 14.3%, and 40.0%, respectively, and of cardiac and noncardiac surgery was 0.8%, 2.1%, 2.6%, and 4.0% and 1.3%, 5.1%, 9.1%, and 31.7%, respectively. We assessed the incidence and the predictors of cardiac death, myocardial infarction, and serious bleeding event within 30 days from surgery. Cardiac death occurred in 438 patients (2.5%), myocardial infarction in 256 (1.5%), and serious bleeding event in 1099 (6.4%). Surgery increased 1.58\u00d7 the risk of cardiac death during follow-up. Along with other risk factors, the interplay between stent type and time from percutaneous coronary intervention to surgery was independently associated with cardiac death\/myocardial infarction. In comparison with bare-metal stent implanted &gt;12 months before surgery, old-generation drug-eluting stent was associated with higher risk of events at any time point. Conversely, new-generation drug-eluting stent showed similar safety as bare-metal stent &gt;12 months and between 6 and 12 months and appeared trendly safer between 0 and 6 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Surgery is frequent in patients with coronary stents and carries a considerable risk of ischemic and bleeding events. Ischemic risk is inversely related with time from percutaneous coronary intervention to surgery and is influenced by stent type.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.115.002155","type":"journal-article","created":{"date-parts":[[2015,12,9]],"date-time":"2015-12-09T14:06:47Z","timestamp":1449670007000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Risk of Adverse Cardiac and Bleeding Events Following Cardiac and Noncardiac Surgery in Patients With Coronary Stent"],"prefix":"10.1161","volume":"9","author":[{"given":"Francesco","family":"Saia","sequence":"first","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Maria Beatrice","family":"Belotti","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Guastaroba","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Berardini","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rossini","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Musumeci","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Guiducci","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Tarantino","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Menozzi","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Varani","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Santarelli","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Tondi","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. Marzocchi); Regional Health Care and Social Agency, Bologna, Italy (L.M.B.B., P.G., R.D.P.); Cardiovascular Department, Papa Giovanni XXIII Hospital, Bergamo, Italy (R.R., G.M.); Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Italy (G.T.); Cardiology Unit, Department of Medical Sciences, Azienda Ospedaliero..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"De Palma","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiology, Cardio-thoraco-vascular Department, University of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy (F.S., A.B., C.R., A. 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