{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:30:06Z","timestamp":1769599806120,"version":"3.49.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Investigation of anginal chest pain has traditionally involved either assessment of the coronary anatomy by angiography or noninvasive testing for reversible ischemia. Invasive pressure wire assessment at the time of angiography offers information on both anatomy and physiology. Fractional flow reserve\u2013guided percutaneous coronary intervention is associated with lower resource utilization and improved clinical outcome compared with angiographic guidance alone. However, the value of routine fractional flow reserve of all major coronary vessels at the time of diagnostic angiography has not been established in a randomized trial despite persuasive observational data. A change in practice to routine fractional flow reserve assessment of all major vessels during diagnostic angiography would require evidence not just of clinical benefit but also of cost effectiveness. This randomized trial aims to test that strategy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>RIPCORD 2 (Does Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of Chest Pain?) is an 1100 patient prospective, multicenter, randomized trial. Participants are randomized, after initial coronary angiography, and in equal proportion, to assessment and management according to (1) conventional angiography only or (2) additional routine pressure wire assessment in all epicardial vessels of sufficient size to be amenable to revascularization. The primary economic outcome measure will be a comparison of healthcare costs at 1 year. The primary quality-of-life outcome measure analysis will compare patient-reported quality-of-life scores at 1 year. Secondary outcome measures include clinical events at 1 year, management strategy (optimal medical therapy with or without revascularization), and angina status at 1 year according to Canadian Cardiovascular Society angina grade.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The aim of the RIPCORD 2 trial is to assess whether a strategy of routine fractional flow reserve\u2013guided assessment and management of all major coronary arteries will be associated with more effective resource utilization, improved quality of life, and better clinical outcome, compared with angiographic guidance alone.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical Trial Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT02892903.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.117.004191","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T01:10:23Z","timestamp":1518743423000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Design and Rationale of the RIPCORD 2 Trial (Does Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of Chest Pain?)"],"prefix":"10.1161","volume":"11","author":[{"given":"Mostafa","family":"Elguindy","sequence":"first","affiliation":[{"name":"From the Institute of Cardiovascular Medicine and Science, London, United Kingdom (M.E., R.S., I.K.); Liverpool Heart and Chest Hospital NHS Foundation Trust, United Kingdom (M.E., R.S., I.K.); Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, United Kingdom (Z.N., N.C.); and Faculty of Medicine, University of Southampton, United Kingdom (N.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"Stables","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Medicine and Science, London, United Kingdom (M.E., R.S., I.K.); Liverpool Heart and Chest Hospital NHS Foundation Trust, United Kingdom (M.E., R.S., I.K.); Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, United Kingdom (Z.N., N.C.); and Faculty of Medicine, University of Southampton, United Kingdom (N.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Nicholas","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Medicine and Science, London, United Kingdom (M.E., R.S., I.K.); Liverpool Heart and Chest Hospital NHS Foundation Trust, United Kingdom (M.E., R.S., I.K.); Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, United Kingdom (Z.N., N.C.); and Faculty of Medicine, University of Southampton, United Kingdom (N.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Kemp","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Medicine and Science, London, United Kingdom (M.E., R.S., I.K.); Liverpool Heart and Chest Hospital NHS Foundation Trust, United Kingdom (M.E., R.S., I.K.); Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, United Kingdom (Z.N., N.C.); and Faculty of Medicine, University of Southampton, United Kingdom (N.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Curzen","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Medicine and Science, London, United Kingdom (M.E., R.S., I.K.); Liverpool Heart and Chest Hospital NHS Foundation Trust, United Kingdom (M.E., R.S., I.K.); Wessex Cardiothoracic Centre, University Hospital Southampton NHS Foundation Trust, United Kingdom (Z.N., N.C.); and Faculty of Medicine, University of Southampton, United Kingdom (N.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","unstructured":"The National Institute for Health and Care Excellence (NICE). Chest Pain of Recent Onset: Assessment and Diagnosis. Guidance CG95 2010 Updated 2016. http:\/\/guidance.nice.org.uk\/CG95."},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.53.4.627"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403293101304"},{"key":"e_1_3_3_5_2","volume-title":"In: Oxford Textbook of Interventional Cardiology","author":"Muller O","year":"2010","unstructured":"Muller O, De Bruyne B. \u201cCoronary physiology in clinical practice\u201d. , Redwood S, Curzen N, Thomas M, eds. In: Oxford Textbook of Interventional Cardiology. New York, NY: Oxford University Press; 2010."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.3.1013"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342604"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.041"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807611"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.24.2928"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.012"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205361"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2013.814856"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2017.01.014"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000978"},{"key":"e_1_3_3_16_2","unstructured":"ICE Cap Research Group Clinical Trial Database. https:\/\/ripcord.aimes.uk\/. Accessed Dec. 26 2017."},{"key":"e_1_3_3_17_2","unstructured":"British Cardiovascular Intervention Society. https:\/\/www.bcis.org.uk\/wp-content\/uploads\/2016\/12\/LUDMAN_P_1013_AUDIT2012.pdf. Accessed Dec. 26 2017."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11078-6"},{"key":"e_1_3_3_19_2","unstructured":"Rioufol G Mewton N Rabilloud M Vaz B Roubille F Perret T Motreff P Ovize M Finet G; AHA Scientific Sessions. The FUnctional Testing Underlying Coronary REvascularization (FUTURE) Study: A \"Real World\" Comparison of Fractional Flow Reserve-guided Management versus Conventional Management in Multi Vessel Coronary Artery Disease Patients. November 2016. http:\/\/www.abstractsonline.com\/pp8\/#!\/4096\/presentation\/58258."}],"container-title":["Circulation: Cardiovascular Quality and Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCOUTCOMES.117.004191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:30:23Z","timestamp":1715571023000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCOUTCOMES.117.004191"}},"subtitle":["A Randomized Controlled Trial to Compare Routine Pressure Wire Assessment With Conventional Angiography in the Management of Patients With Coronary Artery Disease"],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1161\/CIRCOUTCOMES.117.004191"],"URL":"https:\/\/doi.org\/10.1161\/circoutcomes.117.004191","relation":{},"ISSN":["1941-7713","1941-7705"],"issn-type":[{"value":"1941-7713","type":"print"},{"value":"1941-7705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"2017-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e004191"}}