{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:34:21Z","timestamp":1792625661847,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Nearly half of Americans with diagnosed hypertension have uncontrolled blood pressure (BP) while some integrated healthcare systems, such as Kaiser Permanente Northern California, have achieved control rates upwards 90%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results:<\/jats:title>\n                    <jats:p>\n                      We adapted Kaiser Permanente\u2019s evidence-based treatment protocols in a racially and ethnically diverse population at 12 safety-net clinics in the San Francisco Health Network. The intervention consisted of 4 elements: a hypertension registry, a simplified treatment intensification protocol that included fixed-dose combination medications containing diuretics, standardized BP measurement protocol, and BP check visits led by registered nurse and pharmacist staff. The study population comprised patients with hypertension who made \u22651 primary care visits within the past 24 months (n=15 917) and had a recorded BP measurement within the past 12 months. We conducted a postintervention time series analysis from August 2014 to August 2016 to assess the effect of the intervention on BP control for 24 months for the pilot site and for 15 months for 11 other San Francisco Health Network clinics combined. Secondary outcomes were changes in use of guideline-recommended medication prescribing. Rates of BP control increased at the pilot site (68%\u201374%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) and the 11 other San Francisco Health Network clinic sites (69%\u201374%;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01). Statistically significant improvements in BP control rates (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) at the 11 San Francisco Health Network clinic sites occurred in all racial and ethnic groups (blacks, 60%\u201366%; whites, 69%\u201375%; Latinos, 67%\u201372%; Asians, 78%\u201382%). Use of fixed-dose combination medications increased from 10% to 13% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), and the percentage of angiotensin-converting enzyme inhibitor prescriptions dispensed in combination with a thiazide diuretic increased from 36% to 40% (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Evidence-based system approaches to improving BP control can be implemented in safety-net settings and could play a pivotal role in achieving improved population BP control and reducing hypertension disparities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circoutcomes.117.004386","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T05:11:54Z","timestamp":1531372314000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":71,"title":["Adapting and Evaluating a Health System Intervention From Kaiser Permanente to Improve Hypertension Management and Control in a Large Network of Safety-Net Clinics"],"prefix":"10.1161","volume":"11","author":[{"given":"Valy","family":"Fontil","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Zuckerberg San Francisco General Hospital (V.F., R.G., D.G., K.B.-D.)"},{"name":"University of California San Francisco. UCSF Center for Vulnerable Populations at Zuckerberg San Francisco General Hospital (V.F., D.G., K.B.-D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Zuckerberg San Francisco General Hospital (V.F., R.G., D.G., K.B.-D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Moise","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Medical Center, New York, NY (N.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Chen","sequence":"additional","affiliation":[{"name":"San Francisco Department of Public Health, CA (E.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Guzman","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Zuckerberg San Francisco General Hospital (V.F., R.G., D.G., K.B.-D.)"},{"name":"University of California San Francisco. UCSF Center for Vulnerable Populations at Zuckerberg San Francisco General Hospital (V.F., D.G., K.B.-D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Bibbins-Domingo","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Zuckerberg San Francisco General Hospital (V.F., R.G., D.G., K.B.-D.)"},{"name":"Department of Epidemiology and Biostatistics (C.E.M., K.B.-D.)"},{"name":"University of California San Francisco. UCSF Center for Vulnerable Populations at Zuckerberg San Francisco General Hospital (V.F., D.G., K.B.-D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa1406751"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282615"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12516"},{"key":"e_1_3_4_5_2","unstructured":"AHRQ. Expenditures for hypertension among adults age 18 and older 2010: estimates for the U.S. Civilian Noninstitutionalized Population. 2013;2016. https:\/\/meps.ahrq.gov\/data_files\/publications\/st404\/stat404.shtml. 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