{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:33:44Z","timestamp":1791837224473,"version":"4.3.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Catheterization laboratory (cath lab) activation time is a newly available process measure for patients with ST-segment\u2013elevation myocardial infarction requiring inter-hospital transfers for primary percutaneous coronary intervention that reflects inter-facility communication and urgent mobilization of interventional laboratory resources. Our aim was to determine whether faster activation is associated with improved reperfusion time and outcomes in the American Heart Association Mission: Lifeline Accelerator-2 Project.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>From April 2015 to March 2017, treatment times of 2063 patients with ST-segment\u2013elevation myocardial infarction requiring inter-hospital transfer for primary percutaneous coronary intervention from 12 regions around the United States were stratified by cath lab activation time (first hospital arrival to cath lab activation within [timely] or beyond 20 minutes [delayed]). Median cath lab activation time was 26 minutes, with a delayed activation observed in 1241 (60.2%) patients. Prior cardiovascular or cerebrovascular disease, arterial hypotension at admission, and black or Latino ethnicity were independent factors of delayed cath lab activation. Timely cath lab activation patients had shorter door-in door-out times (40 versus 68 minutes) and reperfusion times (98 versus 135 minutes) with 80.1% treated within the national goal of \u2264120 minutes versus 39.0% in the delayed group.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Cath lab activation within 20 minutes across a geographically diverse group of hospitals was associated with performing primary percutaneous coronary intervention within the national goal of \u2264120 minutes in &gt;75% of patients. While several confounding factors were associated with delayed activation, this work suggests that this process measure has the potential to direct resources and practices to more timely treatment of patients requiring inter-hospital transfer for primary percutaneous coronary intervention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.119.006204","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T09:00:15Z","timestamp":1593162015000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Catheterization Laboratory Activation Time in Patients Transferred With ST-Segment\u2013Elevation Myocardial Infarction: Insights From the Mission: Lifeline STEMI Accelerator-2 Project"],"prefix":"10.1161","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9562-3128","authenticated-orcid":true,"given":"Michel","family":"Zeitouni","sequence":"first","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.Z., H.R.A.-K., M.L.R., S.M.D., A.S.H., L.M., C.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein R.","family":"Al-Khalidi","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.Z., H.R.A.-K., M.L.R., S.M.D., A.S.H., L.M., C.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayme L.","family":"Roettig","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.Z., H.R.A.-K., M.L.R., S.M.D., A.S.H., L.M., C.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele M.","family":"Bolles","sequence":"additional","affiliation":[{"name":"American Heart Association, Dallas, TX (M.M.B., Z.M.-I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M.","family":"Doerfler","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.Z., H.R.A.-K., M.L.R., S.M.D., A.S.H., L.M., C.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Fordyce","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of British Columbia, Vancouver, BC, Canada (C.B.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne S.","family":"Hellkamp","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.Z., H.R.A.-K., M.L.R., S.M.D., A.S.H., L.M., C.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"The Carl and Edyth Lindner Center for Research and Education at The Christ Hospital, Cincinnati, OH (T.D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab","family":"Magdon-Ismail","sequence":"additional","affiliation":[{"name":"American Heart Association, Dallas, TX (M.M.B., Z.M.-I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Monk","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.Z., H.R.A.-K., M.L.R., S.M.D., A.S.H., L.M., C.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Darrell","family":"Nelson","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, NC (R.D.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Centra Lynchburg General Hospital, Lynchburg, VA (P.K.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Hadley","family":"Wilson","sequence":"additional","affiliation":[{"name":"Sanger Heart and Vascular Institute, Atrium Health, Charlotte, NC (B.H.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled M.","family":"Ziada","sequence":"additional","affiliation":[{"name":"Gill Heart &amp; Vascular Institute University of Kentucky, Lexington (K.M.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Granger","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (M.Z., H.R.A.-K., M.L.R., S.M.D., A.S.H., L.M., C.B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Jollis","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine, Durham, NC (J.G.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12113-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.100.1.14"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742cf6"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.000136"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002339"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.02.071"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002450"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.862"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.001307"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.033118"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208200"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032446"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019474"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.07.020"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.959643"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004061"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.9.959"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007059"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2015.4.24248"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.12.072"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410901"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.381"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/10903127.2013.836263"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301092"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr403"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz595"}],"container-title":["Circulation: Cardiovascular Quality and Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCOUTCOMES.119.006204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:52:07Z","timestamp":1715572327000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCOUTCOMES.119.006204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1161\/CIRCOUTCOMES.119.006204"],"URL":"https:\/\/doi.org\/10.1161\/circoutcomes.119.006204","relation":{},"ISSN":["1941-7713","1941-7705"],"issn-type":[{"value":"1941-7713","type":"print"},{"value":"1941-7705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2019-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e006204"}}