{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:12:50Z","timestamp":1790496770437,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Circadian rhythms may influence myocardial tolerance to ischemia-reperfusion phenomena occurring during cardiac procedures. While conflicting results exist on the effect of time-of-day on surgical aortic valve replacement (SAVR), afternoon procedures could be associated with a reduced risk of death, rehospitalization or periprocedural myocardial infarction, compared with morning procedures. We examined the impact of procedure time-of-day on outcomes after transcatheter aortic valve replacement (TAVR) or SAVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We analyzed patients at intermediate- or high-surgical risk who underwent elective TAVR (n=4457) or SAVR (n=1129) in the PARTNER (Placement of Aortic Transcatheter Valve) 1 and 2 trials and registries according to time-of-day (morning versus afternoon) using the Kaplan-Meier event rates and multivariable Cox proportional hazards regression models. Sensitivity analysis was conducted using 1:1 propensity-score matching. The primary end point was all-cause death or rehospitalization at 2 years.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              At 2 years, no difference was observed between patients operated in the morning versus the afternoon within the SAVR (32.3% versus 30.6%, adjusted hazard ratio, 1.08 [95% CI, 0.82\u20131.41],\n              <jats:italic>P<\/jats:italic>\n              =0.58) and TAVR cohorts (35.7% versus 35.4%, adjusted hazard ratio, 1.01 [95% CI, 0.89\u20131.14],\n              <jats:italic>P<\/jats:italic>\n              =0.86) with regards to the primary end point. Rates of periprocedural myocardial infarction were low and similar between morning and afternoon in SAVR (1.6% versus 1.0%,\n              <jats:italic>P<\/jats:italic>\n              =0.51) and TAVR (0.4% versus 0.4%,\n              <jats:italic>P<\/jats:italic>\n              =0.86), as were all other clinical end points. Similar results were observed in propensity-score matched analysis.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Procedure time-of-day was not associated with clinical outcomes after TAVR or SAVR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifiers: NCT00530894, NCT01314313, NCT03222141, and NCT03222128.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.121.007948","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T19:01:11Z","timestamp":1642532471000},"source":"Crossref","is-referenced-by-count":9,"title":["Time-of-Day and Clinical Outcomes After Surgical or Transcatheter Aortic Valve Replacement: Insights From the PARTNER Trials"],"prefix":"10.1161","volume":"15","author":[{"given":"Flavien","family":"Vincent","sequence":"first","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval\/Qu\u00e9bec Heart and Lung Institute, Laval University, Canada (F.V., J.T., P.P.)."},{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (F.V., B.R., D.L., A.C., M.C.A., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod H.","family":"Thourani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Marcus Valve Center, Piedmont Heart Institute, Atlanta, GA (V.H.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-5864","authenticated-orcid":true,"given":"Julien","family":"Ternacle","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval\/Qu\u00e9bec Heart and Lung Institute, Laval University, Canada (F.V., J.T., P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (F.V., B.R., D.L., A.C., M.C.A., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"University of Missouri-Kansas City School of Medicine (D.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-9191","authenticated-orcid":true,"given":"Rebecca T.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Columbia University Irving Medical Center, NewYork-Presbyterian Hospital (R.T.H., C.R.S., M.C.A., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditian","family":"Li","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (F.V., B.R., D.L., A.C., M.C.A., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Crowley","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (F.V., B.R., D.L., A.C., M.C.A., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Webb","sequence":"additional","affiliation":[{"name":"Saint Paul\u2019s Hospital, Vancouver, Canada (J.G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Mack","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Baylor Scott &amp; White Health, Plano, TX (M.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":true,"given":"Samir","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Cleveland Clinic, OH (S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Russo","sequence":"additional","affiliation":[{"name":"Robert Wood Johnson Medical School, Rutgers University, New Brunswick (M.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Interventional Vascular Therapy, Columbia University Irving Medical Center, NewYork-Presbyterian Hospital (R.T.H., C.R.S., M.C.A., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-3020","authenticated-orcid":true,"given":"Maria C.","family":"Alu","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (F.V., B.R., D.L., A.C., M.C.A., M.B.L.)."},{"name":"Center for Interventional Vascular Therapy, Columbia University Irving Medical Center, NewYork-Presbyterian Hospital (R.T.H., C.R.S., M.C.A., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (F.V., B.R., D.L., A.C., M.C.A., M.B.L.)."},{"name":"Center for 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