{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:43:12Z","timestamp":1790404992221,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Severe maternal morbidity is rising, yet the association with cardiovascular disease is not clear. We examined the risk of cardiovascular hospitalization up to 3 decades after having a pregnancy complicated by severe maternal morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We analyzed a longitudinal cohort of 1\u2009336\u2009846 women who were pregnant between 1989 and 2019 in Quebec, Canada. The main exposure measure was severe maternal morbidity in any pregnancy, including severe preeclampsia, acute renal failure, sepsis, and other life-threatening conditions. Using time-varying Cox regression models, we compared the adjusted risk of hospitalization for cardiovascular disease up to 3 decades after pregnancy for women with severe maternal morbidity relative to women without severe morbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Five percent of women had severe maternal morbidity. Overall, there were 68\u2009287 cardiovascular hospitalizations during 21\u2009725\u2009672 person-years of follow-up in the cohort. Compared with no morbidity, women with any severe morbidity had a greater risk of cardiovascular hospitalization (hazard ratio [HR], 1.77 [95% CI, 1.72\u20131.82]). The association was the greatest within the first year of delivery (HR, 4.42 [95% CI, 3.77\u20135.19]) but persisted beyond 15 years (HR, 1.44 [95% CI, 1.37\u20131.51]). Having a cardiac complication (HR, 5.37 [95% CI, 4.65\u20136.20]), cerebrovascular accident (HR, 3.82 [95% CI, 2.94\u20134.96]), or acute renal failure (HR, 2.60 [95% CI, 2.15\u20133.14]) during pregnancy was strongly associated with future cardiovascular hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Women with severe maternal morbidity have a greater risk of cardiovascular disease after pregnancy, both in the short and long term. These women may benefit from active surveillance for cardiovascular disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circoutcomes.121.008393","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T05:02:33Z","timestamp":1643605353000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":35,"title":["Severe Maternal Morbidity and Long-Term Risk of Cardiovascular Hospitalization"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-6474","authenticated-orcid":true,"given":"U. Vivian","family":"Ukah","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada (U.V.U., N.D., G.P., N.A.)."},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Montreal, Quebec, Canada (U.V.U., G.P., A.A., N.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Dayan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada (U.V.U., N.D., G.P., N.A.)."},{"name":"Departments of Medicine, Obstetrics and Gynecology, and Research Institute, McGill University Health Centre, Montreal, Quebec, Canada (N.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0316-9026","authenticated-orcid":true,"given":"Brian J.","family":"Potter","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of Montreal Hospital Centre, Montreal, Quebec, Canada (B.J.P.)."},{"name":"University of Montreal Hospital Research Centre, Montreal, Quebec, Canada (B.J.P., A.A., N.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-8047","authenticated-orcid":true,"given":"Gilles","family":"Paradis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada (U.V.U., N.D., G.P., N.A.)."},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Montreal, Quebec, Canada (U.V.U., G.P., A.A., N.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimina","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Montreal, Quebec, Canada (U.V.U., G.P., A.A., N.A.)."},{"name":"University of Montreal Hospital Research Centre, Montreal, Quebec, Canada (B.J.P., A.A., N.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0459","authenticated-orcid":true,"given":"Nathalie","family":"Auger","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Quebec, Canada (U.V.U., N.D., G.P., N.A.)."},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Montreal, Quebec, Canada (U.V.U., G.P., A.A., N.A.)."},{"name":"University of Montreal Hospital Research Centre, Montreal, Quebec, Canada (B.J.P., A.A., N.A.)."},{"name":"Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Quebec, Canada 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La migration interprovinciale au Qu\u00e9bec 2000-2009. 2010. Accessed May 21 2021. 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