{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:45:57Z","timestamp":1788522357949,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Quality and Outcomes"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Understanding how statins, ezetimibe, and PCSK9i (proprotein convertase subtilisin\/kexin type 9 serine protease inhibitors) are prescribed after a myocardial infarction (MI) or elective coronary revascularization may improve lipid-lowering therapy (LLT) intensification and reduce recurrent atherosclerotic cardiovascular disease events. We described the use and intensification of LLT among US veterans who had a MI or elective coronary revascularization between July 24, 2015, and December 9, 2019, within 12 months of hospital discharge.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              LLT intensification was defined as increasing statin dose, or initiating a statin, ezetimibe, or a PCSK9i, overall and among those with an LDL-C (low-density lipoprotein cholesterol)\n              <jats:italic>\u2265<\/jats:italic>\n              70 or 100 mg\/dL. Poisson regression was used to determine patient characteristics associated with a greater likelihood of LLT intensification following hospitalization for MI or elective coronary revascularization.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Among 81\u2009372 index events (mean age, 69.0 years, 2.3% female, mean LDL-C 89.6 mg\/dL, 33.8% with LDL-C &lt;70 mg\/dL), 39.7% were not taking any LLT, and 22.0%, 37.2%, and 0.6% were taking a low-moderate intensity statin, a high-intensity statin, and ezetimibe, respectively, before MI\/coronary revascularization during the study period. Within 14 days, 3 months, and 12 months posthospitalization, 33.3%, 41.9%, and 47.3%, respectively, of veterans received LLT intensification. LLT intensification was most common among veterans taking no LLT (82.5%, n=26\u2009637) before MI\/coronary revascularization. Higher baseline LDL-C, having a lipid test, and attending a cardiology visit were each associated with a greater likelihood of LLT intensification, while age\n              <jats:italic>\u2265<\/jats:italic>\n              75 versus &lt;65 years was associated with a lower likelihood of LLT intensification within 12 months posthospitalization.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Less than half of veterans received LLT intensification in the year after MI or coronary revascularization suggesting a missed opportunity to reduce atherosclerotic cardiovascular disease risk.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circoutcomes.121.008861","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T09:00:37Z","timestamp":1665738037000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Lipid-Lowering Therapy Use and Intensification Among United States Veterans Following Myocardial Infarction or Coronary Revascularization Between 2015 and 2019"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-782X","authenticated-orcid":true,"given":"Alexander R.","family":"Zheutlin","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Utah, Salt Lake City (A.R.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7382-4607","authenticated-orcid":true,"given":"Catherine G.","family":"Derington","sequence":"additional","affiliation":[{"name":"Division of Health System Innovation and Research, Department of Population Health Sciences (C.G.D., A.P.B.), University of Utah School of Medicine, Salt Lake City."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9257-8843","authenticated-orcid":true,"given":"Jennifer S.","family":"Herrick","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Internal Medicine (J.S.H.), University of Utah School of Medicine, Salt Lake City."},{"name":"Informatics, Decision Enhancement and Analytic Sciences (IDEAS) Center of Innovation, Veterans Affairs Salt Lake City Health Care System, UT (J.S.H., A.P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Rosenson","sequence":"additional","affiliation":[{"name":"Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY (R.S.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-2561","authenticated-orcid":true,"given":"Bharat","family":"Poudel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham School of Public Health (B.P., P.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-0563","authenticated-orcid":true,"given":"Monika M.","family":"Safford","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine (E.A.J., T.M.B.), University of Alabama at Birmingham."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5086-0418","authenticated-orcid":true,"given":"Elizabeth A.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine (E.A.J., T.M.B.), University of Alabama at Birmingham."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9800-5296","authenticated-orcid":true,"given":"Mark","family":"Woodward","sequence":"additional","affiliation":[{"name":"The George Institute for Global Health, School of Public Health, Imperial College London, United Kingdom (M.W.)."},{"name":"The George Institute for Global Health, University of New South Wales, Sydney, Australia (M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0494-7448","authenticated-orcid":true,"given":"Stephanie","family":"Reading","sequence":"additional","affiliation":[{"name":"Center for Observational Research, Amgen, Inc, Thousand Oaks, CA (S.R., K.O., J.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Orroth","sequence":"additional","affiliation":[{"name":"Center for Observational Research, Amgen, Inc, Thousand Oaks, CA (S.R., K.O., J.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Exter","sequence":"additional","affiliation":[{"name":"Center for Observational Research, Amgen, Inc, Thousand Oaks, CA (S.R., K.O., J.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-6954","authenticated-orcid":true,"given":"Salim S.","family":"Virani","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX (S.S.V.)."},{"name":"Health Policy and Quality Program, Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and Development Center of Excellence, Houston, TX (S.S.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-5492","authenticated-orcid":true,"given":"Paul","family":"Muntner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham School of Public Health (B.P., P.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-5039","authenticated-orcid":true,"given":"Adam P.","family":"Bress","sequence":"additional","affiliation":[{"name":"Division of Health System Innovation and Research, Department of Population Health Sciences (C.G.D., A.P.B.), University of Utah School of Medicine, Salt Lake City."},{"name":"Informatics, Decision Enhancement and Analytic Sciences (IDEAS) Center of Innovation, Veterans Affairs Salt Lake City Health Care System, UT (J.S.H., A.P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7014e1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.13985"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.615"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000625"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410489"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501031"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.25505"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2019.05.012"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-018-6810-1"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.4700"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.07.012"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv116"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000743"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X08089277"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2019.2481"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.025"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.1810"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.006646"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.11.011"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.12.030"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.006019"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2020.03.006"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.08.014"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0001"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.5.485"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.117.003939"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2016.14251"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.13063\/2327-9214.1023"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2018.11.001"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092286"}],"container-title":["Circulation: Cardiovascular Quality and Outcomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCOUTCOMES.121.008861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:19:32Z","timestamp":1715570372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCOUTCOMES.121.008861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1161\/CIRCOUTCOMES.121.008861"],"URL":"https:\/\/doi.org\/10.1161\/circoutcomes.121.008861","relation":{},"ISSN":["1941-7713","1941-7705"],"issn-type":[{"value":"1941-7713","type":"print"},{"value":"1941-7705","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"2021-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}