{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T16:48:20Z","timestamp":1782060500468,"version":"3.54.5"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Population Health and Outcomes"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The aim of the DESAC study (Devenir des Survivants d\u2019Arrets Cardiaques) was to describe the survival rate and neurological status of out-of-hospital (out-of-hospital cardiac arrest) survivors, and to assess the influence of prehospital and intrahospital factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Between July 2015 and October 2018, consecutive nontraumatic out-of-hospital cardiac arrest patients aged over 18 years discharged alive from 33 intensive care units in Paris and the suburbs (France) were included. Their neurological status was assessed every 6 months using the Cerebral Performance Category (CPC) scale. Prognostic factors associated with a favorable neurological outcome at 24 months (CPC category of 1 or 2) were assessed by covariate-adjusted logistic regression. Trajectories of CPC level over time were derived using a linear mixed model in survivors with at least 3 repeated assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Out of 593 survivors, 525 were followed up for 24 months (mean age, 58.1\u00b115.3 years, 79% males), and 449 of 525 (86%) had a favorable neurological outcome. Initial shockable rhythm (adjusted odds ratio, 3.33 [95% CI, 1.57\u20137.07]) and previous practice of sport (adjusted odds ratio, 3.13 [95% CI, 1.21\u20138.12]) were associated with favorable outcome, whereas factors with reduced odds ratio were older age (adjusted odds ratio per 10 years, 0.53 [95% CI, 0.41\u20130.69]) and prior percutaneous coronary intervention (adjusted odds ratio, 0.38 [95% CI, 0.17\u20130.85]). Therapeutic hypothermia or acute coronary interventions were not related to prognosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt;0.05). Overall, among the 514 patients with at least 3 repeated assessments, 5 distinct CPC trajectories (2 reflecting early death were combined) were derived: 64% remained in CPC1, 13.4% in CPC2, 11% improved from CPC2 to CPC1, and 11.6% died either early or lately (&gt;3 months) during follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>This multicentric prospective study indicates that 86% of out-of-hospital cardiac arrest survivors had a favorable neurological outcome at 24 months. Pre-event and intraevent factors (including previous practice of sport and shockable rhythm), but not in-hospital management (therapeutic hypothermia or acute coronary interventions), were associated with a favorable outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02494414.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circoutcomes.125.012269","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T09:00:15Z","timestamp":1775725215000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Long-Term Neurological Outcome of Out-of-Hospital Cardiac Arrest Survivors and Associated Factors: Results of the DESAC Study, a French Multicentric Prospective Cohort"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-7909","authenticated-orcid":true,"given":"Florence","family":"Dumas","sequence":"first","affiliation":[{"name":"Emergency Department, Cochin Hospital-APHP, Paris Cardiovascular Research Centre, INSERM U970 (F.D.), Sudden Death Expertise Centre, Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1821-7713","authenticated-orcid":true,"given":"Wulfran","family":"Bougouin","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Institut Jacques Cartier, Massy, France (W.B., C.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2798-1334","authenticated-orcid":true,"given":"Marie-C\u00e9cile","family":"Perier","sequence":"additional","affiliation":[{"name":"Inserm, PARCC, F-75015 (M.-C.P., F.B., E.M., X.J., J.-P.E., A. Cariou), Sudden Death Expertise Centre, Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Marin","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Cochin Hospital, APHP Centre (N.M., A. Cariou), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-5719","authenticated-orcid":true,"given":"Cyril","family":"Goulenok","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Institut Jacques Cartier, Massy, France (W.B., C.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Vieillard-Baron","sequence":"additional","affiliation":[{"name":"Medical and Surgical Intensive Care Unit, Ambroise Par\u00e9 Hospital-APHP, UMR 1018, Versailles\u2013Saint Quentin en Yvelines University, Boulogne-Billancourt, France (A.V.-B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-6762","authenticated-orcid":true,"given":"Jean-Luc","family":"Diehl","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, European Georges Pompidou Hospital-APHP (J.-L.D.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4782-6734","authenticated-orcid":true,"given":"St\u00e9phane","family":"Legriel","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Andre Mignot Hospital, Versailles, France (S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1652-1540","authenticated-orcid":true,"given":"Nicolas","family":"Deye","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Lariboisiere Hospital-APHP (N.D.), Universit\u00e9 Paris Cit\u00e9, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4558-7314","authenticated-orcid":true,"given":"Pierrick","family":"Cronier","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Centre Hospitalier Sud Francilien Hospital, Corbeille-Essonnes, France (P.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5132-9248","authenticated-orcid":true,"given":"Sylvie","family":"Ricome","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Robert Ballanger Hospital, Aulnay-sous-bois, France (S.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6834-1803","authenticated-orcid":true,"given":"Frank","family":"Chemouni","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Grand H\u00f4pital de l\u2019Est Francilien, Marne-la-Vall\u00e9e, France (F.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-5577","authenticated-orcid":true,"given":"Armand","family":"Mekontso-Dessap","sequence":"additional","affiliation":[{"name":"Medical Intensive Care Unit, Henri Mondor Hospital-APHP, Paris Est University, Paris, France (A.M.-D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-5102","authenticated-orcid":true,"given":"Beno\u00eet","family":"Champigneulle","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France (B.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6030-3957","authenticated-orcid":true,"given":"Alain","family":"Combes","sequence":"additional","affiliation":[{"name":"M\u00e9decine Intensive R\u00e9animation, Sorbonne Universit\u00e9, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re (AP-HP), Paris, France (A. 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