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Despite robust efficacy data from randomized trials, real-world implementation of guideline-recommended lipid-lowering therapies is suboptimal. Barriers to the implementation of guideline lipid-lowering therapy recommendations exist at the healthcare systems level, the medical therapy level, and the patient level. A combination of strategies, including the incorporation of quality improvement and cost-effectiveness analysis among payers, pharmacist-based educational initiatives, digital health tools directed towards patients, the simplification of drug regimens via polypill, and emerging novel therapies, including\n                      <jats:italic toggle=\"yes\">PCSK9<\/jats:italic>\n                      gene silencing and editing technologies, may bridge these implementation gaps. This review highlights challenges and solutions to alleviating barriers to optimal implementation of guideline-recommended lipid-lowering therapies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circoutcomes.125.012330","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:00:15Z","timestamp":1772445615000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Barriers and Emerging Strategies to Bridge Gaps in Implementation of Evidence-Based Lipid-Lowering Therapies"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5045-8496","authenticated-orcid":true,"given":"Christopher S.","family":"Marnell","sequence":"first","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY (C.S.M., 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