{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:50:31Z","timestamp":1780505431063,"version":"3.54.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Population Health and Outcomes"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Estimating risk and risk factors for cardiovascular disease (CVD) events and mortality following CVD events can inform strategies for lowering risk in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We estimated risk factors for the 5-year cumulative incidence of CVD events including nonfatal myocardial infarction, fatal coronary heart disease, stroke, and heart failure among adults aged &lt;70, 70 to &lt;80, and \u226580 years in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. The REGARDS study is a prospective cohort study with enrollment across the contiguous United States and adjudicated CVD events. Data on CVD risk factors were collected during a study interview and in-home study visit from 2013 to 2016. In addition, we estimated 1-year mortality after the first CVD event during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Among 4621, 4938, and 2450 participants aged &lt;70, 70 to &lt;80, and \u226580 years, the 5-year cumulative incidence of CVD events was 5.3% (95% CI, 4.7%\u20136.0%), 10.7% (95% CI, 9.9%\u201311.6%), and 17.2% (95% CI, 15.8%\u201318.8%), respectively. Diabetes and hypertension were associated with CVD events among participants aged &lt;70 years (hazard ratio [HR], 1.42 [95% CI, 1.00\u20132.03] and 1.58 [95% CI, 1.19\u20132.09], respectively) and 70 to &lt;80 years (HR, 1.41 [95% CI, 1.09\u20131.83] and 1.73 [95% CI, 1.43\u20132.08], respectively) but not among those aged \u226580 years (HR, 1.03 [95% CI, 0.81\u20131.32] and 1.07 [95% CI, 0.84\u20131.35], respectively). Among those aged \u226580 years, risk factors for CVD events included LDL-C (low-density lipoprotein-cholesterol) \u2265100 mg\/dL (HR, 1.24 [95% CI, 1.01\u20131.51]), hsCRP (high-sensitivity C-reactive protein) \u22653 mg\/L (HR, 1.27 [95% CI, 1.03\u20131.55]), albuminuria (HR, 1.61 [95% CI, 1.30\u20131.98]), and a prior history of CVD (HR, 2.25 [95% CI, 1.84\u20132.76]). Among participants aged \u226580 years, the 1-year cumulative incidence of all-cause mortality following a CVD event was 53.1% (95% CI, 48.3%\u201357.8%) versus 5.7% (95% CI, 3.5%\u20137.9%) in age-matched participants who did not have a CVD event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The risk for CVD events in adults aged \u226580 years was high, and the association was stronger for albuminuria and inflammation versus hypertension and diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circoutcomes.125.012379","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T10:00:17Z","timestamp":1771581617000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular Events in US Adults Aged \u226580 Years: Incidence, Risk Factors, and Outcomes"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4711-5492","authenticated-orcid":true,"given":"Paul","family":"Muntner","sequence":"first","affiliation":[{"name":"Perisphere Real World Evidence, LLC, Austin, TX (P.M.)."},{"name":"Department of Epidemiology, University of Alabama at Birmingham (P.M., E.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-0563","authenticated-orcid":true,"given":"Monika M.","family":"Safford","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S., P.G., R.-J.R., M.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-3737","authenticated-orcid":true,"given":"Parag","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S., P.G., R.-J.R., M.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-1424","authenticated-orcid":true,"given":"Karen P.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke Health, Durham, NC (K.P.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5429-3852","authenticated-orcid":true,"given":"Emily B.","family":"Levitan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham (P.M., E.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5745-1636","authenticated-orcid":true,"given":"Michael G.","family":"Nanna","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT (M.G.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-4872","authenticated-orcid":true,"given":"Ro-Jay","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S., P.G., R.-J.R., M.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9928-4407","authenticated-orcid":true,"given":"Madeline R.","family":"Sterling","sequence":"additional","affiliation":[{"name":"Department of Medicine, Weill Cornell Medicine, New York, NY (M.M.S., P.G., R.-J.R., M.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-8623","authenticated-orcid":true,"given":"C. 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