{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:29:17Z","timestamp":1787077757351,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Population Health and Outcomes"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Survivors of aortic dissection frequently restrict personal physical activity due to concerns about provoking recurrent aortic events. We conducted a multicenter randomized controlled trial to evaluate the safety and feasibility of a moderate-intensity, home-based guided exercise (GE) regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Between December 2022 and October 2024, adults \u22653 months post-Type A or B thoracic aortic dissection were randomized at 3 US academic medical centers to GE or usual care (UC; standardized exercise counseling and routine clinic visits). GE participants completed individualized training on a 6-exercise circuit and performed 12 months of home exercise with virtual follow-up visits. Coprimary outcomes were safety (aortic events, exertional hypertension, symptoms, injury, or events requiring medical care) and Patient-Reported Outcomes Measurement Information System 29-Item Profile scores. Secondary outcomes included exertional and ambulatory blood pressure and adherence. Continuous outcomes were compared using\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      or Mann-Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      tests; categorical using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      or Fisher tests.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Ninety-three participants (mean age, 56 years; 30% women; 67% Type A aortic dissection) were randomized to GE (n=44) or UC (n=49). Sixteen participants (5 GE and 11 UC) were lost to follow-up, and 65 participants completed all trial milestones. There were no deaths, aortic operations, or recurrent dissections in either group. Exertional hypertension during supervised training occurred in 17 (39%) GE participants and was mitigated by exercise modification. There were no significant changes in paired ambulatory blood pressure measurements (25 GE, 28 UC) or Patient-Reported Outcomes Measurement Information System 29-Item Profile scores (30 GE, 35 UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In this pilot randomized trial, moderate-intensity home exercise appeared feasible and was not associated with observed excess aortic events compared with usual care. Larger prospective trials are needed to determine long-term effects on cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circoutcomes.126.013292","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:00:25Z","timestamp":1782982825000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Feasibility of Moderate-Intensity Home-Based Guided Exercise in Aortic Dissection Survivors in the United States: A Multicenter Randomized Controlled Trial"],"prefix":"10.1161","volume":"19","author":[{"given":"Dipika","family":"Bhatia","sequence":"first","affiliation":[{"name":"John P and Kathrine G McGovern Medical School, University of Texas Health Science Center at Houston (D.B., N.E., K.H., Y.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5933-491X","authenticated-orcid":true,"given":"Nikhil","family":"Erabelli","sequence":"additional","affiliation":[{"name":"John P and Kathrine G McGovern Medical School, University of Texas Health Science Center at Houston (D.B., N.E., K.H., Y.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"House","sequence":"additional","affiliation":[{"name":"John P and Kathrine G McGovern Medical School, University of Texas Health Science Center at Houston (D.B., N.E., K.H., Y.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9184-8928","authenticated-orcid":true,"given":"Yasmin","family":"Toy","sequence":"additional","affiliation":[{"name":"John P and Kathrine G McGovern Medical School, University of Texas Health Science Center at Houston (D.B., N.E., K.H., Y.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-5566","authenticated-orcid":true,"given":"Michelle S.","family":"Lim","sequence":"additional","affiliation":[{"name":"Central Sydney Cardiology, New South Wales, Australia (M.S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2810-6960","authenticated-orcid":true,"given":"Leslie M.","family":"Boyer","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis, MO (L.M.B., A.C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0031-0191","authenticated-orcid":true,"given":"Kim A.","family":"Eagle","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor (K.A.E., M.K.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-6000","authenticated-orcid":true,"given":"Marion K.","family":"Hofmann Bowman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Michigan, Ann Arbor (K.A.E., M.K.H.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-310X","authenticated-orcid":true,"given":"Alan C.","family":"Braverman","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine in St. Louis, MO (L.M.B., A.C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-9624","authenticated-orcid":true,"given":"Siddharth K.","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Texas Health Science Center at Houston (S.K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001106"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22418"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000094530"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.056546"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198603063141003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2010.13"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007959"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00132.2017"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731403"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd11120379"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd007130"},{"key":"e_1_3_3_13_2","volume-title":"Aortic Dissection","author":"Levy D","year":"2024","unstructured":"Levy D, Goyal A, Grigorova Y, Le JK, Liu F. 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