{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:53Z","timestamp":1792521593767,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Population Health and Outcomes"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Although the effectiveness of Lp(a) (lipoprotein[a])\u2013lowering therapies remains under study, lipid guidelines now recommend Lp(a) testing in all adults to identify individuals who need more aggressive risk factor modification. Therefore, we evaluate contemporary patterns of Lp(a) testing and the impact of testing on LDL-C (low-density lipoprotein cholesterol) management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Electronic health record patient data from 13 US health systems from January 1, 2021 to January 1, 2025, were utilized to assess the annual proportion of patients with atherosclerotic cardiovascular disease who underwent Lp(a) testing. Multivariable logistic regression was used to identify factors associated with (1) Lp(a) testing and (2) high Lp(a) (\u2265125 nmol\/L or \u226550 mg\/dL). Changes in lipid-lowering therapy after Lp(a) testing were evaluated, stratified by Lp(a) level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 1\u2009948\u2009540 patients with atherosclerotic cardiovascular disease (44% female sex; mean age, 70.9\u00b112.8 years), 36\u2009410 (1.9%) had an Lp(a) test. Testing increased slightly over time but remained low: from 0.2% in 2021 to 0.8% in 2024. Among tested patients, 31.1% had elevated Lp(a). Although female sex (odds ratio, 0.95 [95% CI, 0.93\u20130.98]) and non-Hispanic Black patients (0.79 [95% CI, 0.76\u20130.82]) were less likely to undergo testing, these groups had higher odds of elevated Lp(a) (1.19 [95% CI, 1.14\u20131.25] and 2.83 [95% CI, 2.63\u20133.05], respectively). Intensification of lipid-lowering therapy in those with LDL-C\u226555 mg\/dL increased with higher Lp(a) levels: 32.7% with Lp(a) 125 to &lt;200 nmol or 50 to &lt;80 mg\/dL, and 38.2% with Lp(a)\u2265200 nmol or \u226580 mg\/dL had lipid-lowering therapy intensification (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Lp(a) testing remains low despite guideline recommendations. Although those with elevated Lp(a) were more likely to undergo lipid-lowering therapy intensification, over half of those with Lp(a)\u2265200 nmol\/L or \u2265 80 mg\/dL had no change in therapy. These results highlight a significant gap in clinical care and an opportunity to improve the use of Lp(a) testing to guide LDL-C management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circoutcomes.126.013883","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T15:15:08Z","timestamp":1788102908000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Lipoprotein (a) Testing and Changes in Lipid-Lowering Therapy in Patients With ASCVD: Findings From the cvMOBIUS-2 Registry"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-7132","authenticated-orcid":true,"given":"Nishant P.","family":"Shah","sequence":"first","affiliation":[{"name":"Duke University School of Medicine, Durham, NC (N.P.S.)."},{"name":"Division of Cardiology, Duke Clinical Research Institute, Durham, NC (N.P.S., P.S., N.F., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Shrader","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke Clinical Research Institute, Durham, NC (N.P.S., P.S., N.F., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-4855","authenticated-orcid":true,"given":"Nikki","family":"Freeman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke Clinical Research Institute, Durham, NC (N.P.S., P.S., N.F., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-7215","authenticated-orcid":true,"given":"Satoshi","family":"Shoji","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke Clinical Research Institute, Durham, NC (N.P.S., P.S., N.F., S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-7251","authenticated-orcid":true,"given":"Cezary","family":"Wojcik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laney K.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John N.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5415-4721","authenticated-orcid":true,"given":"Eric D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Texas Southwestern Medical Center, Dallas (E.D.P., A.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6197-9860","authenticated-orcid":true,"given":"Ann 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