{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:10:58Z","timestamp":1791054658394,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2008,5,23]]},"abstract":"<jats:p>\n            Altered regulation of signaling pathways can lead to pathologies including cardiac hypertrophy and heart failure. We report that neonatal and adult cardiomyocytes express chromogranin B (CGB), a Ca\n            <jats:sup>2+<\/jats:sup>\n            binding protein that modulates Ca\n            <jats:sup>2+<\/jats:sup>\n            release by the inositol 1,4,5-trisphosphate receptor (InsP\n            <jats:sub>3<\/jats:sub>\n            R). Using fluorescent Ca\n            <jats:sup>2+<\/jats:sup>\n            indicator dyes, we found that CGB regulates InsP\n            <jats:sub>3<\/jats:sub>\n            -dependent Ca\n            <jats:sup>2+<\/jats:sup>\n            release in response to angiotensin II, an octapeptide hormone that promotes cardiac hypertrophy. ELISA experiments and luciferase reporter assays identified angiotensin II as a potent inducer of brain natriuretic peptide (BNP), a hormone that recently emerged as an important biomarker in cardiovascular disease. CGB was found to regulate angiotensin II\u2013stimulated and basal secretion, expression and promoter activity of BNP that depend on the InsP\n            <jats:sub>3<\/jats:sub>\n            R. Moreover, we provide evidence that CGB acts via the transcription activity of nuclear factor \u03baB in an InsP\n            <jats:sub>3<\/jats:sub>\n            \/Ca\n            <jats:sup>2+<\/jats:sup>\n            -dependent manner but independent of nuclear factor of activated T cells. In vivo experiments further showed that cardiac hypertrophy induced by angiotensin II, a condition characterized by increased ventricular BNP production, is associated with upregulation of ventricular CGB expression. Overexpression of CGB in cardiomyocytes, in turn, induced the BNP promoter. The evidence presented in this study identifies CGB as a novel regulator of cardiomyocyte InsP\n            <jats:sub>3<\/jats:sub>\n            \/Ca\n            <jats:sup>2+<\/jats:sup>\n            -dependent signaling, nuclear factor \u03baB activity, and BNP production.\n          <\/jats:p>","DOI":"10.1161\/circresaha.107.166033","type":"journal-article","created":{"date-parts":[[2008,4,18]],"date-time":"2008-04-18T01:23:50Z","timestamp":1208481830000},"page":"1230-1238","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Chromogranin B Regulates Calcium Signaling, Nuclear Factor \u03baB Activity, and Brain Natriuretic Peptide Production in Cardiomyocytes"],"prefix":"10.1161","volume":"102","author":[{"given":"Felix M.","family":"Heidrich","sequence":"first","affiliation":[{"name":"From the Departments of Pharmacology (F.M.H., K.Z., B.E.E.) and Medicine\/Cardiology (Y.H., F.J.G.), Yale University, New Haven, Conn; Department of Pharmacology and Toxicology (F.M.H.), Dresden University of Technology, Germany; Neuroscience Research Centre (K.Z.), Charite\u0301 Universita\u0308tsmedizin, Berlin, Germany; and Department of Physiology and Biophysics (M.E.), University of Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Departments of Pharmacology (F.M.H., K.Z., B.E.E.) and Medicine\/Cardiology (Y.H., F.J.G.), Yale University, New Haven, Conn; Department of Pharmacology and Toxicology (F.M.H.), Dresden University of Technology, Germany; Neuroscience Research Centre (K.Z.), Charite\u0301 Universita\u0308tsmedizin, Berlin, Germany; and Department of Physiology and Biophysics (M.E.), University of Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Estrada","sequence":"additional","affiliation":[{"name":"From the Departments of Pharmacology (F.M.H., K.Z., B.E.E.) and Medicine\/Cardiology (Y.H., F.J.G.), Yale University, New Haven, Conn; Department of Pharmacology and Toxicology (F.M.H.), Dresden University of Technology, Germany; Neuroscience Research Centre (K.Z.), Charite\u0301 Universita\u0308tsmedizin, Berlin, Germany; and Department of Physiology and Biophysics (M.E.), University of Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"From the Departments of Pharmacology (F.M.H., K.Z., B.E.E.) and Medicine\/Cardiology (Y.H., F.J.G.), Yale University, New Haven, Conn; Department of Pharmacology and Toxicology (F.M.H.), Dresden University of Technology, Germany; Neuroscience Research Centre (K.Z.), Charite\u0301 Universita\u0308tsmedizin, Berlin, Germany; and Department of Physiology and Biophysics (M.E.), University of Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Giordano","sequence":"additional","affiliation":[{"name":"From the Departments of Pharmacology (F.M.H., K.Z., B.E.E.) and Medicine\/Cardiology (Y.H., F.J.G.), Yale University, New Haven, Conn; Department of Pharmacology and Toxicology (F.M.H.), Dresden University of Technology, Germany; Neuroscience Research Centre (K.Z.), Charite\u0301 Universita\u0308tsmedizin, Berlin, Germany; and Department of Physiology and Biophysics (M.E.), University of Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"From the Departments of Pharmacology (F.M.H., K.Z., B.E.E.) and Medicine\/Cardiology (Y.H., F.J.G.), Yale University, New Haven, Conn; Department of Pharmacology and Toxicology (F.M.H.), Dresden University of Technology, Germany; Neuroscience Research Centre (K.Z.), Charite\u0301 Universita\u0308tsmedizin, Berlin, Germany; and Department of Physiology and Biophysics (M.E.), University of Chile, Santiago."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02084"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117739"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13976-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000109415.17511.18"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.07.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001041"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S146479310400644X"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107532200"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309307200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3632006re15"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4313-04.2005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27374"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510876103"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.27.3.715"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003415200"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi048070w"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1603"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1110"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-13-05344.2002"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0524"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.73.3.8348687"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.102.25.3074"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118162"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)37619-6"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00320.2006"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00624-2"},{"key":"e_1_3_3_28_2","first-page":"553","volume":"37","year":"2004","unstructured":"Mackenzie L, Roderick HL, Proven A, Conway SJ, Bootman MD. Inositol 1,4,5-trisphosphate receptors in the heart. Biol Res. 2004; 37: 553\u2013557.","journal-title":"Biol Res"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01809-5"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.38.23961"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414212200"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/386855a0"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7362"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.107.166033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:36:17Z","timestamp":1715571377000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.107.166033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,23]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,5,23]]}},"alternative-id":["10.1161\/CIRCRESAHA.107.166033"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.107.166033","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,23]]},"assertion":[{"value":"2008-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}