{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:14:08Z","timestamp":1791252848101,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2008,9,26]]},"abstract":"<jats:p>\n            Conotruncal and ventricular septal congenital heart anomalies result from defects in formation and division of the embryonic outflow tract. Cardiac remodeling during outflow tract and ventricular septation converts the tubular embryonic heart into a parallel circulatory system with an independent left ventricular outlet and right ventricular inlet.\n            <jats:italic>Tbx3<\/jats:italic>\n            encodes a T-box\u2013containing transcription factor expressed in the developing conduction system of the heart. Mutations in\n            <jats:italic>TBX3<\/jats:italic>\n            cause ulnar\u2013mammary syndrome. Here we show that mice lacking\n            <jats:italic>Tbx3<\/jats:italic>\n            develop severe outflow tract defects, including connection of both the aorta and pulmonary trunk with the right ventricle, in addition to aortic arch artery anomalies and abnormal communication between the right atrium and left ventricle. Alignment defects are preceded by a delay in caudal displacement of the arterial pole of the heart during aortic arch artery formation. Embryonic anterior\u2013posterior patterning and cardiac chamber development are unaffected in\n            <jats:italic>Tbx3<\/jats:italic>\n            mutant embryos. However, the contribution of second heart field derived progenitor cells to the arterial pole of the heart is impaired.\n            <jats:italic>Tbx3<\/jats:italic>\n            is expressed in pharyngeal epithelia and neural crest cells in the pharyngeal region, suggesting an indirect role in second heart field deployment. Loss of Tbx3 affects multiple signaling pathways regulating second heart field proliferation and outflow tract morphogenesis, including fibroblast growth factor signaling, leading to a failure of normal heart tube extension and consequent atrioventricular and ventriculoarterial alignment defects.\n          <\/jats:p>","DOI":"10.1161\/circresaha.108.172858","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T02:18:33Z","timestamp":1219371513000},"page":"743-750","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":97,"title":["Tbx3 Is Required for Outflow Tract Development"],"prefix":"10.1161","volume":"103","author":[{"given":"Karim","family":"Mesbah","sequence":"first","affiliation":[{"name":"From the Developmental Biology Institute of Marseilles\u2013Luminy (K.M., M.T.-R., R.G.K.), Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Avenir Group, UMR 6216 Centre National de la Recherche Scientifique\u2013Universite\u0301 de la Me\u0301diterrane\u0301e, Campus de Luminy, Marseille, France; and College of Physicians and Surgeons (Z.H., V.E.P.), Columbia University, New York. Present address for Z.H.: Skaggs School of Pharmacy, University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Harrelson","sequence":"additional","affiliation":[{"name":"From the Developmental Biology Institute of Marseilles\u2013Luminy (K.M., M.T.-R., R.G.K.), Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Avenir Group, UMR 6216 Centre National de la Recherche Scientifique\u2013Universite\u0301 de la Me\u0301diterrane\u0301e, Campus de Luminy, Marseille, France; and College of Physicians and Surgeons (Z.H., V.E.P.), Columbia University, New York. Present address for Z.H.: Skaggs School of Pharmacy, University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"The\u0301veniau-Ruissy","sequence":"additional","affiliation":[{"name":"From the Developmental Biology Institute of Marseilles\u2013Luminy (K.M., M.T.-R., R.G.K.), Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Avenir Group, UMR 6216 Centre National de la Recherche Scientifique\u2013Universite\u0301 de la Me\u0301diterrane\u0301e, Campus de Luminy, Marseille, France; and College of Physicians and Surgeons (Z.H., V.E.P.), Columbia University, New York. Present address for Z.H.: Skaggs School of Pharmacy, University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia E.","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"From the Developmental Biology Institute of Marseilles\u2013Luminy (K.M., M.T.-R., R.G.K.), Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Avenir Group, UMR 6216 Centre National de la Recherche Scientifique\u2013Universite\u0301 de la Me\u0301diterrane\u0301e, Campus de Luminy, Marseille, France; and College of Physicians and Surgeons (Z.H., V.E.P.), Columbia University, New York. Present address for Z.H.: Skaggs School of Pharmacy, University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Kelly","sequence":"additional","affiliation":[{"name":"From the Developmental Biology Institute of Marseilles\u2013Luminy (K.M., M.T.-R., R.G.K.), Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Avenir Group, UMR 6216 Centre National de la Recherche Scientifique\u2013Universite\u0301 de la Me\u0301diterrane\u0301e, Campus de Luminy, Marseille, France; and College of Physicians and Surgeons (Z.H., V.E.P.), Columbia University, New York. Present address for Z.H.: Skaggs School of Pharmacy, University of California, San Diego."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2004.06.004"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1710"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10364"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.12.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.02.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.39.073003.105925"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-6518-z"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199608)206:4<379::AID-AJA4>3.0.CO;2-F"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01378"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00431"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797-311"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.01.030"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.222902"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10487"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000258019.74591.b3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.416007"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000398"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.03.007"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(01)00040-5"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.77.2.211"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20575"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02408"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02367"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.16.3179"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02824"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.21.5081"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng2112"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9317"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.02.052"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.19.4605"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2005.04.021"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.108.172858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:25:37Z","timestamp":1715570737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.108.172858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,26]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,9,26]]}},"alternative-id":["10.1161\/CIRCRESAHA.108.172858"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.108.172858","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,26]]},"assertion":[{"value":"2008-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}