{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:52:51Z","timestamp":1790938371690,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2008,8,15]]},"abstract":"<jats:p>\n            The ductus arteriosus is a specialized blood vessel containing highly differentiated and contractile vascular smooth muscle, derived largely from neural crest cells, that is essential for fetal life but typically closes after birth. Impaired development of the ductus arteriosus or disruption of signaling pathways that initiate postnatal closure can result in persistent patency of the ductus arteriosus, the third most common congenital heart defect. We found that Tfap2\u03b2, a transcription factor associated with patent ductus arteriosus in humans, was uniquely expressed in mouse ductal smooth muscle.\n            <jats:italic>Endothelin-1<\/jats:italic>\n            and the hypoxia-induced transcription factor,\n            <jats:italic>Hif2<\/jats:italic>\n            \u03b1 were also highly enriched in ductal smooth muscle at embryonic day 13.5 and were dependent on Tfap2\u03b2 for their expression in this domain. Hif2\u03b1 functioned as a negative regulator of Tfap2\u03b2-induced transcription by disrupting protein\u2013DNA interactions, suggesting a negative feedback loop regulating Tfap2\u03b2 activity. Our data indicate that Tfap2\u03b2, Et-1, and Hif2\u03b1 act in a transcriptional network during ductal smooth muscle development and that disruption of this pathway may contribute to patent ductus arteriosus by affecting the development of smooth muscle within the ductus arteriosus.\n          <\/jats:p>","DOI":"10.1161\/circresaha.108.180661","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T02:05:14Z","timestamp":1216346714000},"page":"388-395","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Transcriptional Regulation During Development of the Ductus Arteriosus"],"prefix":"10.1161","volume":"103","author":[{"given":"Kathryn N.","family":"Ivey","sequence":"first","affiliation":[{"name":"From the Departments of Pediatrics and Molecular Biology (K.N.I., D. Srivastava), Pathology and Molecular Biology (D. Sutcliffe, J.R.), and Internal Medicine (J.A.G.), University of Texas Southwestern Medical Center, Dallas; and Cardiovascular Research Institute (R.I.C.), Department of Pediatrics, University of California, San Francisco. Present address for K.I. and D. Srivastava: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and Molecular Biology (K.N.I., D. Srivastava), Pathology and Molecular Biology (D. Sutcliffe, J.R.), and Internal Medicine (J.A.G.), University of Texas Southwestern Medical Center, Dallas; and Cardiovascular Research Institute (R.I.C.), Department of Pediatrics, University of California, San Francisco. Present address for K.I. and D. Srivastava: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Richardson","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and Molecular Biology (K.N.I., D. Srivastava), Pathology and Molecular Biology (D. Sutcliffe, J.R.), and Internal Medicine (J.A.G.), University of Texas Southwestern Medical Center, Dallas; and Cardiovascular Research Institute (R.I.C.), Department of Pediatrics, University of California, San Francisco. Present address for K.I. and D. Srivastava: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald I.","family":"Clyman","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and Molecular Biology (K.N.I., D. Srivastava), Pathology and Molecular Biology (D. Sutcliffe, J.R.), and Internal Medicine (J.A.G.), University of Texas Southwestern Medical Center, Dallas; and Cardiovascular Research Institute (R.I.C.), Department of Pediatrics, University of California, San Francisco. Present address for K.I. and D. Srivastava: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Garcia","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and Molecular Biology (K.N.I., D. Srivastava), Pathology and Molecular Biology (D. Sutcliffe, J.R.), and Internal Medicine (J.A.G.), University of Texas Southwestern Medical Center, Dallas; and Cardiovascular Research Institute (R.I.C.), Department of Pediatrics, University of California, San Francisco. Present address for K.I. and D. Srivastava: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Srivastava","sequence":"additional","affiliation":[{"name":"From the Departments of Pediatrics and Molecular Biology (K.N.I., D. Srivastava), Pathology and Molecular Biology (D. Sutcliffe, J.R.), and Internal Medicine (J.A.G.), University of Texas Southwestern Medical Center, Dallas; and Cardiovascular Research Institute (R.I.C.), Department of Pediatrics, University of California, San Francisco. Present address for K.I. and D. Srivastava: Gladstone Institute of Cardiovascular Disease, University of California, San Francisco."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00187468"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02309"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.17.5.1003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/75578"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/323410"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.15.1938"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90425-1"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/368703a0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.5.813"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2698"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.16.3005"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(02)00097-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.4.H1521"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000049516.70216.2E"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2003.09.027"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1139\/y91-033"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1145503"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400784200"},{"key":"e_1_3_3_20_2","unstructured":"Sambrook J Fritsch EF Maniatis T. Expression of cloned genes in cultured mammalian cells. In: C.Nolan ed. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor NY: Cold Spring Harbor Press; 1989: 66\u201367."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.21.3320"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1048903"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.12.7095"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9454"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011344200"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.1.72"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8543"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.4.2060"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000064703.92382.50"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/35014065"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/36342"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0202-91"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1059"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.17.9759"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28639"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30349"},{"key":"e_1_3_3_37_2","first-page":"574","volume":"132","year":"1988","unstructured":"De Reeder EG, Girard N, Poelmann RE, Van Munsteren JC, Patterson DF, Gittenberger-De Groot AC. Hyaluronic acid accumulation and endothelial cell detachment in intimal thickening of the vessel wall. The normal and genetically defective ductus arteriosus. Am J Pathol. 1988; 132: 574\u2013585.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199204002-00011"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)90436-O"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.108.180661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:08:25Z","timestamp":1715573305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.108.180661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,15]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,8,15]]}},"alternative-id":["10.1161\/CIRCRESAHA.108.180661"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.108.180661","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,15]]},"assertion":[{"value":"2008-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}