{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:43:39Z","timestamp":1790516619502,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2009,3,13]]},"abstract":"<jats:p>The migration of vascular smooth muscle cells (VSMCs) plays an essential role during the development of atherosclerosis and restenosis. Extensive studies have implicated the importance of extracellular matrix (ECM)-degrading proteinases in VSMC migration. A recently described family of proteinases, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTs), is capable of degrading vascular ECM proteins. Here, we sought to determine whether ADAMTS-7 is involved in VSMC migration and neointima formation in response to vascular injury. ADAMTS-7 protein accumulated preferentially in neointima of the carotid artery wall after balloon injury. In primary VSMCs, ADAMTS-7 level was enhanced by the proinflammatory cytokine tumor necrosis factor \u03b1 and growth factor platelet-derived growth factor-BB. ADAMTS-7 overexpression greatly accelerated and small interfering RNA knockdown markedly retarded VSMC migration\/invasion in vitro. In addition, luminal delivery of ADAMTS-7 adenovirus to carotid arteries exacerbated intimal thickening nearly sixfold 7 days after injury. Conversely, perivascular administration of ADAMTS-7 small interfering RNA but not scramble small interfering RNA to injured arteries attenuated intimal thickening by 50% at 14 days after injury. Furthermore, ADAMTS-7 mediated degradation of the vascular ECM cartilage oligomeric matrix protein (COMP) in injured vessels. Replenishing COMP circumvented the promigratory effect of ADAMTS-7 on VSMCs. Enforced expression of COMP significantly suppressed VSMC migration and neointima formation postinjury, which indicates that ADAMTS-7 facilitated intimal hyperplasia through degradation of inhibitory matrix protein COMP. ADAMTS-7 may therefore serve as a novel therapeutic target for atherosclerosis and postangioplasty restenosis.<\/jats:p>","DOI":"10.1161\/circresaha.108.188425","type":"journal-article","created":{"date-parts":[[2009,1,22]],"date-time":"2009-01-22T22:04:40Z","timestamp":1232661880000},"page":"688-698","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":195,"title":["ADAMTS-7 Mediates Vascular Smooth Muscle Cell Migration and Neointima Formation in Balloon-Injured Rat Arteries"],"prefix":"10.1161","volume":"104","author":[{"given":"Li","family":"Wang","sequence":"first","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingang","family":"Zheng","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-ju","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingbo","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanping","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kong","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Physiology and Pathophysiology (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), School of Basic Medical Sciences, Peking University, Beijing, People\u2019s Republic of China; Key Laboratory of Molecular Cardiovascular Science (L.W., X.B., B.L., Y.Z., N.W., W.K., X.W.), Ministry of Education, Beijing, People\u2019s Republic of China; Department of Cardiology (J.Z.), China-Japan Friendship Hospital, Beijing, People\u2019s Republic of China; Department of Orthopaedic Surgery and Department of Cell..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<300::AID-PATH596>3.0.CO;2-I"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2308"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.11.026"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040424"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8635"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000150045.27127.37"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.107.156653"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.05.018"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3877fje"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.21.1.47"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvb.17.3.490"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.85.5.387"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/359067a0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.30"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000040420.17366.2e"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115613"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000258492.96097.47"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.02.033"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10435"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2006.03.011"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.11.1151"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M009512200"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705735200"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2006.01.001"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.76.2.176"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.100.8.861"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33483"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.160978"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.108.165993"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.108.188425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:30:50Z","timestamp":1715556650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.108.188425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,13]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,3,13]]}},"alternative-id":["10.1161\/CIRCRESAHA.108.188425"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.108.188425","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,13]]},"assertion":[{"value":"2009-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}