{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:49:38Z","timestamp":1792237778354,"version":"4.4.0"},"reference-count":156,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2009,1,2]]},"abstract":"<jats:p>Reentry is the main mechanism of life-threatening ventricular arrhythmias, including ventricular fibrillation and tachycardia. Its occurrence depends on the simultaneous presence of an arrhythmogenic substrate (a preexisting condition) and a \u201ctrigger,\u201d and is favored by electrophysiological heterogeneities. In the adult heart, electrophysiological heterogeneities of the ventricle exist along the apicobasal, left\u2013right, and transmural axes. Also, conduction is preferentially slowed in the right ventricular outflow tract, especially during pharmacological sodium channel blockade. We propose that the origin of electrophysiological heterogeneities of the adult heart lies in early heart development. The heart is formed from several progenitor regions: the first heart field predominantly forms the left ventricle, whereas the second heart field forms the right ventricle and outflow tract. Furthermore, the embryonic outflow tract consists of slowly conducting tissue until it is incorporated into the ventricles and develops rapidly conducting properties. The subepicardial myocytes and subendocardial myocytes run distinctive gene programs from their formation onwards. This review discusses the hypothesis that electrophysiological heterogeneities in the adult heart result from persisting patterns in gene expression and function along the craniocaudal and epicardial\u2013endocardial axes of the developing heart. Understanding the developmental origins of electrophysiological heterogeneity contributing to ventricular arrhythmias may give rise to new therapies.<\/jats:p>","DOI":"10.1161\/circresaha.108.188698","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T21:47:48Z","timestamp":1230760068000},"page":"19-31","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":131,"title":["Developmental Basis for Electrophysiological Heterogeneity in the Ventricular and Outflow Tract Myocardium As a Substrate for Life-Threatening Ventricular Arrhythmias"],"prefix":"10.1161","volume":"104","author":[{"given":"Bastiaan J.D.","family":"Boukens","sequence":"first","affiliation":[{"name":"From the Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent M.","family":"Christoffels","sequence":"additional","affiliation":[{"name":"From the Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Coronel","sequence":"additional","affiliation":[{"name":"From the Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoon F.M.","family":"Moorman","sequence":"additional","affiliation":[{"name":"From the Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.4960280103"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00289-3"},{"key":"e_1_3_3_3_2","first-page":"43","year":"1914","unstructured":"Mines GR. On circulating excitations in heart muscle and their possible relation to tachycardia and fibrillation. Trans Roy Soc Can. 1914; 43\u201352.","journal-title":"Trans Roy Soc Can"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.39.2.168"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1996.0012"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1997.tb01012.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.80.1.2736748"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.77.5.3359590"},{"key":"e_1_3_3_9_2","first-page":"801","volume":"139","year":"1991","unstructured":"Smith JH, Green CR, Peters NS, Rothery S, Severs NJ. Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy. Am J Pathol. 1991; 139: 801\u2013821.","journal-title":"Am J Pathol"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.03.022"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.104.25.3069"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.86.2.1638716"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.73.2.8330380"},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","unstructured":"Wiegerinck RF van Veen AAB Schumacher CA Norman M de Bakker JM Coronel R. Transmural dispersion of refractoriness and conduction velocity is associated with heterogeneously reduced connexin43 in a rabbit model of heart failure. Heart Rhythm. 2008.","DOI":"10.1016\/j.hrthm.2008.04.026"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.01.005"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.532614"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.03.005"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000118467.53182.d1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.52.3.6825220"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.11.022"},{"key":"e_1_3_3_21_2","first-page":"306","volume":"59","year":"2007","unstructured":"Feng Y, Dai DZ, Na T, Cui B, Wang T, Zhang Y, Dai Y. Endothelin receptor antagonist CPU0213 suppresses ventricular fibrillation in L-thyroxin induced cardiomyopathy. Pharmacol Rep. 2007; 59: 306\u2013314.","journal-title":"Pharmacol Rep"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1619fje"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.01033.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-1606(03)00112-X"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000013072.51957.b7"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00784-8"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00006.2003"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/35025190"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1998.8849"},{"key":"e_1_3_3_30_2","doi-asserted-by":"crossref","unstructured":"Bakker ML Boukens BJ Mommersteeg MT Brons JF Wakker V Moorman AF Christoffels VM. Transcription Factor Tbx3 Is Required for the Specification of the Atrioventricular Conduction System. Circ Res. 2008.","DOI":"10.1161\/CIRCRESAHA.107.169565"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00493-7"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.004"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01378"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-6518-z"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10487"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1710"},{"key":"e_1_3_3_37_2","first-page":"661","volume":"123","year":"1977","unstructured":"De la Cruz MV, Sanchez GC, Arteaga MM, Arguello C. Experimental study of the development of the truncus and the conus in the chick embryo. J Anat. 1977; 123: 661\u2013686.","journal-title":"J Anat"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.69.6.1659499"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00133-3"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00061-9"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.2.H369"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.93.1.168"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00526.2004"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0841n.x"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0443k.x"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2005"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.98.18.1921"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.126714"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.075861"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.70.1.1727690"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1998.sp004156"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.76.3.351"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.516583"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2006.11.022"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.81.1.128"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018263"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.024"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.79.3.474"},{"key":"e_1_3_3_59_2","first-page":"H548","volume":"271","year":"1996","unstructured":"Di Diego JM, Sun ZQ, Antzelevitch C. I(to) and action potential notch are smaller in left vs. right canine ventricular epicardium. Am J Physiol. 1996; 271: H548\u2013H561.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.2.206"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00717-4"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.10.011"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-0736(95)80042-5"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.67.5.2225348"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.53.4.6627611"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.14.1.44"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.565804"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90308-N"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2001.tb00063.x"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1308"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1109\/10.464369"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00271.x"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.653949"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2005.10.018"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79569-3"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-007-9046-8"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.099358"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01710-7"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2005.06.005"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.527325"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000117402.70689.75"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.539072"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5301.841"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.11.002"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm118"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1445-z"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00987.2003"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070310511"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.02.010"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03514.x"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.12.030"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2006.05.002"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021150014764"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.0937"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.03.007"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum128"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02365.x"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00115-0"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.520999"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02379-5"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1086\/344208"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.624502"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5373.108"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.416007"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.04.036"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00405-2"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-30"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-21"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19846"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1159\/000092569"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.613182"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.105.4.985"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.222902"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0133"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.163188"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(02)02642-2"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2006.02.045"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.08.041"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2004.09.002"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000262688.14288.b8"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0697-154"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01562"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.11.4627-4635.2004"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.02.122"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1999.9298"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9748"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00750"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00131-9"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.84.12.1365"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1161\/res.71.2.1628384"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/1050-1738(94)90029-9"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.01.001"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg843"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.12.004"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.03487.x"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(200024)97:4<280::AID-AJMG1278>3.0.CO;2-N"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20398"},{"key":"e_1_3_3_138_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01017.2006"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.58.030196.002453"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.12.011"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2006.12.013"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00947"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20284"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21572"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07807-8"},{"key":"e_1_3_3_146_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.20.8960-8970.2005"},{"key":"e_1_3_3_147_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9801"},{"key":"e_1_3_3_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.04.002"},{"key":"e_1_3_3_149_2","first-page":"121","volume":"165","year":"1989","unstructured":"De la Cruz MV, Sanchez-Gomez C, Palomino MA. The primitive cardiac regions in the straight tube heart (Stage 9) and their anatomical expression in the mature heart: an experimental study in the chick embryo. J Anat. 1989; 165: 121\u2013131.","journal-title":"J Anat"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02777"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02156"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02607"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03620.x"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.10.007"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.042"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.09.021"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.108.188698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:20:38Z","timestamp":1715570438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.108.188698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,2]]},"references-count":156,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,2]]}},"alternative-id":["10.1161\/CIRCRESAHA.108.188698"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.108.188698","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,2]]},"assertion":[{"value":"2009-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}