{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:43:14Z","timestamp":1774345394407,"version":"3.50.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2009,3,13]]},"abstract":"<jats:p>\n            Myocardial infarction is commonly complicated by left ventricular remodeling, a process that leads to cardiac dilatation, congestive heart failure and death. The innate immune system plays a pivotal role in the remodeling process via nuclear factor (NF)-\u03baB activation. The NF-\u03baB transcription factor family includes several subunits (p50, p52, p65, c-Rel, and Rel B) that respond to myocardial ischemia. The function of NF-\u03baB p50, however, is controversial in this process. To clarify the role of NF-\u03baB p50 in postinfarct left ventricular remodeling, myocardial infarction was induced in wild-type 129Bl6 mice and NF-\u03baB p50-deficient mice. Without affecting infarct size, deletion of NF-\u03baB p50 markedly increased the extent of expansive remodeling (end-diastolic volume: 176\u00b113 \u03bcL versus 107\u00b111 \u03bcL;\n            <jats:italic>P<\/jats:italic>\n            =0.003) and aggravated systolic dysfunction (left ventricular ejection fraction: 16.1\u00b11.5% versus 24.7\u00b13.7%;\n            <jats:italic>P<\/jats:italic>\n            =0.029) in a 28-day time period. Interstitial fibrosis and hypertrophy in the noninfarcted myocardium was increased in NF-\u03baB p50 knockout mice. In the infarct area, a lower collagen density was observed, which was accompanied by an increased number of macrophages, higher gelatinase activity and increased inflammatory cytokine expression. In conclusion, targeted deletion of NF-\u03baB p50 results in enhanced cardiac remodeling and functional deterioration following myocardial infarction by increasing matrix remodeling and inflammation.\n          <\/jats:p>","DOI":"10.1161\/circresaha.108.189746","type":"journal-article","created":{"date-parts":[[2009,1,25]],"date-time":"2009-01-25T01:25:26Z","timestamp":1232846726000},"page":"699-706","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["Targeted Deletion of Nuclear Factor \u03baB p50 Enhances Cardiac Remodeling and Dysfunction Following Myocardial Infarction"],"prefix":"10.1161","volume":"104","author":[{"given":"Leo","family":"Timmers","sequence":"first","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Karlijn","family":"van Keulen","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imo E.","family":"Hoefer","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs F.L.","family":"Meijs","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"van Middelaar","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"den Ouden","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cees J.A.","family":"van Echteld","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Pasterkamp","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique P.V.","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"From the Department of Cardiology (L.T., J.K.v.K., I.E.H., M.F.L.M., B.v.M., K.d.O., C.J.A.v.E., G.P., D.P.V.d.K.), University Medical Center Utrecht; and Interuniversity Cardiology Institute of The Netherlands (J.K.v.K., D.P.V.d.K.), Utrecht."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00630-0"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.89.1.8281697"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000070420.51787.a8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000036014.90197.fa"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.158220"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60618-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.10.110194.002201"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81318-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-894"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00549.2006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1604322"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.6.1651"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02342.x"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.647230"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.09.028"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000101921.93016.1c"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00170.2004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000108929.93074.0b"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01175.2005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5133fje"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.02.007"},{"key":"e_1_3_3_22_2","first-page":"482","volume":"82","year":"1998","unstructured":"Spinale FG, Coker ML, Thomas CV, Walker JD, Mukherjee R, Hebbar L. Time-dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure: relation to ventricular and myocyte function. CircRes. 1998; 82: 482\u2013495.","journal-title":"CircRes"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000046449.36178.00"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000091087.78630.79"},{"key":"e_1_3_3_25_2","first-page":"55","volume":"106","year":"2000","unstructured":"Ducharme A, Frantz S, Aikawa M, Rabkin E, Lindsey M, Rohde LE, Schoen FJ, Kelly RA, Werb Z, Libby P, Lee RT. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction. J ClinInvest. 2000; 106: 55\u201362.","journal-title":"J ClinInvest"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602222200"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.08.005"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000147233.10318.23"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.108.189746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:30:52Z","timestamp":1715571052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.108.189746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,13]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,3,13]]}},"alternative-id":["10.1161\/CIRCRESAHA.108.189746"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.108.189746","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,13]]},"assertion":[{"value":"2009-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}