{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:00:35Z","timestamp":1791352835809,"version":"4.3.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2009,7,2]]},"abstract":"<jats:p>\n                    The L-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel (LTCC) is the major mediator of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    influx in cardiomyocytes, leading to both mechanical contraction and activation of signaling cascades. Among these Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -activated cascades is calcineurin, a protein phosphatase that promotes hypertrophic growth of the heart. Coimmunoprecipitations from heart extracts and pulldowns using heterologously expressed proteins provided evidence for direct binding of calcineurin at both the N and C termini of \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    1.2. At the C terminus, calcineurin bound specifically at amino acids 1943 to 1971, adjacent to a well-characterized protein kinase (PK)A\/PKC\/PKG phospho-acceptor site Ser1928. In vitro assays demonstrated that calcineurin can dephosphorylate \u03b1\n                    <jats:sub>1<\/jats:sub>\n                    1.2. Channel function was increased in voltage-clamp recordings of\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>Ca,L<\/jats:sub>\n                    from cultured cardiomyocytes expressing constitutively active calcineurin, consistent with previous observations in cardiac hypertrophy in vivo. Conversely, acute suppression of calcineurin pharmacologically or with specific peptides decreased\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>Ca,L<\/jats:sub>\n                    . These data reveal direct physical interaction between the LTCC and calcineurin in heart. Furthermore, they demonstrate that calcineurin induces robust increases in\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>Ca,L<\/jats:sub>\n                    and highlight calcineurin as a key modulator of pathological electrical remodeling in cardiac hypertrophy.\n                  <\/jats:p>","DOI":"10.1161\/circresaha.109.199828","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T21:54:54Z","timestamp":1243547694000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":105,"title":["Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca\n                    <sup>2+<\/sup>\n                    Channel"],"prefix":"10.1161","volume":"105","author":[{"given":"Samvit","family":"Tandan","sequence":"first","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanggan","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane D.","family":"Hall","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes W.","family":"Hell","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Luo","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly A.","family":"Rothermel","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. Present address for Y.W.: Department of Pediatrics, Emory University, Atlanta, Ga."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Hill","sequence":"additional","affiliation":[{"name":"From the Departments of Internal Medicine (Cardiology) (S.T., Y.W., T.T.W., N.J., X.L., B.A.R., J.A.H.) and Molecular Biology (J.A.H.), University of Texas Southwestern Medical Center, Dallas; and Department of Pharmacology (D.D.H., J.W.H.), University of Iowa, Iowa City. 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