{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:15:36Z","timestamp":1779189336534,"version":"3.51.4"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2010,4,2]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:underline>Rationale<\/jats:underline>\n                :\n              <\/jats:italic>\n            <\/jats:bold>\n            Apolipoprotein E-null mice with a 129S6\/SvEvTac strain background (129-apoE) develop atherosclerotic plaques faster in the aortic arch but slower in the aortic root than those with a C57BL\/6J background (B6-apoE). The shape of the aortic arch also differs in the 2 strains.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:underline>Objective<\/jats:underline>\n                :\n              <\/jats:italic>\n            <\/jats:bold>\n            Because circulating plasma factors are the same at both locations, we tested the hypothesis that genetic factors affecting vascular geometry also affect the location and extent of atherosclerotic plaque development.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:underline>Methods and Results<\/jats:underline>\n                :\n              <\/jats:italic>\n            <\/jats:bold>\n            Tests on the F2 progeny from a cross between 129-apoE-null and B6-apoE-null mice showed that the extent of atherosclerosis in the aortic arch is significantly correlated in males, but not in females, with the shape of arch curvature (\n            <jats:italic>r<\/jats:italic>\n            =0.34,\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0001) and weakly with the arch diameter (\n            <jats:italic>r<\/jats:italic>\n            =0.20,\n            <jats:italic>P<\/jats:italic>\n            =0.02). Quantitative trait locus (QTL) analysis identified 2 significant peaks for aortic arch lesion size on chromosome 1 (105 Mb, LOD=5.0, and 163 Mb, LOD=6.8), and a suggestive QTL on chromosome 15 (96 Mb, LOD=4.7). A significant QTL for aortic root lesion size was on chromosome 9 (61 Mb, LOD=6.9), but it was distinct from the QTLs for arch lesion size. Remarkably, the QTLs for susceptibility to atherosclerosis in the arch overlapped with a significant QTL that affects curvature of the arch on chromosome 1 (121 Mb, LOD=5.6) and a suggestive QTL on chromosome 15 (76 Mb, LOD=3.5).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:underline>Conclusions<\/jats:underline>\n                :\n              <\/jats:italic>\n            <\/jats:bold>\n            The overlapping QTLs for curvature of the aortic arch and atherosclerosis support that the ontogeny of the aortic arch formation is a potential risk factor for atherosclerosis.\n          <\/jats:p>","DOI":"10.1161\/circresaha.109.207175","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T03:35:36Z","timestamp":1265340936000},"page":"1052-1060","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Aortic Arch Curvature and Atherosclerosis Have Overlapping Quantitative Trait Loci in a Cross Between 129S6\/SvEvTac and C57BL\/6J Apolipoprotein E\u2013Null Mice"],"prefix":"10.1161","volume":"106","author":[{"given":"Hirofumi","family":"Tomita","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Zhilicheva","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinja","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyo","family":"Maeda","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel 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