{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:53:15Z","timestamp":1792626795445,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2010,9,3]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:underline>Rationale:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>Chronic low-grade inflammation involving adipose tissue likely contributes to the metabolic consequences of obesity. The cytokine interleukin (IL)-33 and its receptor ST2 are expressed in adipose tissue, but their role in adipose tissue inflammation during obesity is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Objective:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>To examine the functional role of IL-33 in adipose tissues and investigate the effects on adipose tissue inflammation and obesity in vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Methods and Results:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      We demonstrate that treatment of adipose tissue cultures in vitro with IL-33 induced production of Th2 cytokines (IL-5, IL-13, IL-10) and reduced expression of adipogenic and metabolic genes. Administration of recombinant IL-33 to genetically obese diabetic (\n                      <jats:italic>ob\/ob<\/jats:italic>\n                      ) mice led to reduced adiposity, reduced fasting glucose and improved glucose and insulin tolerance. IL-33 also induced accumulation of Th2 cells in adipose tissue and polarization of adipose tissue macrophages toward an M2 alternatively activated phenotype (CD206\n                      <jats:sup>+<\/jats:sup>\n                      ), a lineage associated with protection against obesity-related metabolic events. Furthermore, mice lacking endogenous ST2 fed high-fat diet had increased body weight and fat mass and impaired insulin secretion and glucose regulation compared to WT controls fed high-fat diet.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Conclusions:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>In conclusion, IL-33 may play a protective role in the development of adipose tissue inflammation during obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.110.218867","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T23:17:55Z","timestamp":1279235875000},"page":"650-658","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":305,"title":["Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice"],"prefix":"10.1161","volume":"107","author":[{"given":"Ashley M.","family":"Miller","sequence":"first","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren L.","family":"Asquith","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel J.","family":"Hueber","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Anderson","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Holmes","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"McKenzie","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damo","family":"Xu","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain B.","family":"McInnes","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foo Y.","family":"Liew","sequence":"additional","affiliation":[{"name":"From the Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre (A.M.M., D.L.A., A.J.H., L.A.A., D.X., I.B.M., F.Y.L.); Glasgow Experimental MRI Centre, Wellcome Surgical Institute (W.M.H.); and British Heart Foundation Glasgow Cardiovascular Research Centre (N.S.), University of Glasgow; and Medical Research Council Laboratory of Molecular Biology (A.N.M.), Cambridge, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.638379"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.108.165100"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0674"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.177105"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1964"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2001"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2002"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29881"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0335-z"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.3.8351"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2003.50096"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1415"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065213"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0533"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.4.2551"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000038705.69871.d9"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047274.66749.FE"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071868"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.081"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23606"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20100"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.01.006"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.01.002"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.5.787"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.04.003"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003331"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802449"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30634"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.04.002"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08636"},{"key":"e_1_3_5_36_2","first-page":"3338","article-title":"Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss","volume":"85","author":"Bastard JP","year":"2000","unstructured":"Bastard JP, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M, Vidal H, Hainque B. 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