{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:40:37Z","timestamp":1791895237458,"version":"4.3.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:underline>Rationale:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>Mitochondrial dysfunction has been implicated in several cardiovascular diseases; however, the roles of mitochondrial oxidative stress and DNA damage in hypertensive cardiomyopathy are not well understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Objective:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>We evaluated the contribution of mitochondrial reactive oxygen species (ROS) to cardiac hypertrophy and failure by using genetic mouse models overexpressing catalase targeted to mitochondria and to peroxisomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Methods and Results:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>Angiotensin II increases mitochondrial ROS in cardiomyocytes, concomitant with increased mitochondrial protein carbonyls, mitochondrial DNA deletions, increased autophagy and signaling for mitochondrial biogenesis in hearts of angiotensin II\u2013treated mice. The causal role of mitochondrial ROS in angiotensin II\u2013induced cardiomyopathy is shown by the observation that mice that overexpress catalase targeted to mitochondria, but not mice that overexpress wild-type peroxisomal catalase, are resistant to cardiac hypertrophy, fibrosis and mitochondrial damage induced by angiotensin II, as well as heart failure induced by overexpression of G\u03b1q. Furthermore, primary damage to mitochondrial DNA, induced by zidovudine administration or homozygous mutation of mitochondrial polymerase \u03b3, is also shown to contribute directly to the development of cardiac hypertrophy, fibrosis and failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Conclusions:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>These data indicate the critical role of mitochondrial ROS in cardiac hypertrophy and failure and support the potential use of mitochondrial-targeted antioxidants for prevention and treatment of hypertensive cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.110.232306","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:17:31Z","timestamp":1297383451000},"page":"837-846","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":503,"title":["Mitochondrial Oxidative Stress Mediates Angiotensin II\u2013Induced Cardiac Hypertrophy and G\u03b1q Overexpression\u2013Induced Heart Failure"],"prefix":"10.1161","volume":"108","author":[{"given":"Dao-Fu","family":"Dai","sequence":"first","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Villarin","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Chin","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Nieves-Cintr\u00f3n","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Marcinek","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Gerald W.","family":"Dorn","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. James","family":"Kang","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas A.","family":"Prolla","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F.","family":"Santana","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Rabinovitch","sequence":"additional","affiliation":[{"name":"From the Departments of Pathology (D.-F.D., S.C.J., T.C., P.S.R.), Radiology (J.J.V., D.J.M.), Cardiovascular Medicine (M.T.C.), Physiology and Biophysics (M.N.-C., L.F.S.), University of Washington, Seattle; Department of Internal Medicine (G.W.D.), Washington University School of Medicine, St Louis, MO; Departments of Medicine and Pharmacology and Toxicology (Y.J.K.), University of Louisville School of Medicine, KY; and Department of Genetics and Medical Genetics (T.A.P.), University of..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00241-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.19.2396"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000012569.55432.02"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.162800"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000157169.27818.ae"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022567"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00368-6"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106653"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.822403"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.028"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.61"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.95"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.09.024"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.21.12610"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540004800502"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.15.8121"},{"key":"e_1_3_4_18_2","first-page":"742","article-title":"Abnormal skeletal and cardiac muscle mitochondria induced by zidovudine (AZT) in human muscle in vitro and in an animal model","volume":"65","author":"Lamperth L","year":"1991","unstructured":"Lamperth L, Dalakas MC, Dagani F, Anderson J, Ferrari R . 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