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Macroautophagy serves in intracellular quality control also by selectively segregating defective organelles (eg, mitochondria) and targeting them for degradation by the lysosome. Inadequate protein quality control is observed in a large subset of failing human hearts with a variety of causes, and its pathogenic role has been experimentally demonstrated. Multiple posttranslational modifications can occur to substrate proteins and protein quality control machineries, promoting or hindering the removal of the misfolded proteins. This article highlights recent advances in posttranslational modification\u2013mediated regulation of intracellular quality control mechanisms and its known involvement in cardiac pathology.<\/jats:p>","DOI":"10.1161\/circresaha.112.268706","type":"journal-article","created":{"date-parts":[[2013,1,17]],"date-time":"2013-01-17T21:33:53Z","timestamp":1358458433000},"page":"367-381","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":79,"title":["Posttranslational Modification and Quality Control"],"prefix":"10.1161","volume":"112","author":[{"given":"Xuejun","family":"Wang","sequence":"first","affiliation":[{"name":"From the Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, Vermillion, SD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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