{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:34:33Z","timestamp":1785483273688,"version":"3.56.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2013,1,4]]},"abstract":"<jats:sec>\n            <jats:title>\n              <jats:underline>Rationale:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>Cardiac myocyte hypertrophy is the main compensatory response to chronic stress on the heart. p90 ribosomal S6 kinase (RSK) family members are effectors for extracellular signal-regulated kinases that induce myocyte growth. Although increased RSK activity has been observed in stressed myocytes, the functions of individual RSK family members have remained poorly defined, despite being potential therapeutic targets for cardiac disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Objective:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>To demonstrate that type 3 RSK (RSK3) is required for cardiac myocyte hypertrophy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Methods and Results:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>RSK3 contains a unique N-terminal domain that is not conserved in other RSK family members. We show that this domain mediates the regulated binding of RSK3 to the muscle A-kinase anchoring protein scaffold, defining a novel kinase anchoring event. Disruption of both RSK3 expression using RNA interference and RSK3 anchoring using a competing muscle A-kinase anchoring protein peptide inhibited the hypertrophy of cultured myocytes. In vivo, RSK3 gene deletion in the mouse attenuated the concentric myocyte hypertrophy induced by pressure overload and catecholamine infusion.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Conclusions:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>Taken together, these data demonstrate that anchored RSK3 transduces signals that modulate pathologic myocyte growth. Targeting of signaling complexes that contain select kinase isoforms should provide an approach for the specific inhibition of cardiac myocyte hypertrophy and for the development of novel strategies for the prevention and treatment of heart failure.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.112.276162","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T05:30:16Z","timestamp":1348205416000},"page":"128-139","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Anchored p90 Ribosomal S6 Kinase 3 Is Required for Cardiac Myocyte Hypertrophy"],"prefix":"10.1161","volume":"112","author":[{"given":"Jinliang","family":"Li","sequence":"first","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Kritzer","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J. Carlisle","family":"Michel","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Le","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrishikesh","family":"Thakur","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Gayanilo","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine L.","family":"Passariello","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Negro","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Danial","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Oskouei","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sanders","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Hare","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Hanauer","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Dodge-Kafka","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. Miller School of Medicine, University of Miami, Miami, FL; Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire CNRS, INSERM, ULP, Strasbourg, France (A.H.); and..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kapiloff","sequence":"additional","affiliation":[{"name":"From the Cardiac Signal Transduction and Cellular Biology Laboratory, Interdisciplinary Stem Cell Institute, Departments of Pediatrics and Medicine (J.L., M.D.K., J.J.C.M., H.T., M.G., C.P., A.N., J.B.D., M.S., M.S.K.), and Interdisciplinary Stem Cell Institute, Department of Medicine, Cardiovascular Division (J.M.H.), Leonard M. 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