{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:39:11Z","timestamp":1792679951777,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2013,1,4]]},"abstract":"<jats:sec>\n            <jats:title>\n              <jats:underline>Rationale:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>\n              CD34\n              <jats:sup>+<\/jats:sup>\n              transplantation in dilated cardiomyopathy was associated with short-term improvement in left ventricular ejection fraction and exercise tolerance.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Objective:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>\n              We investigated long-term effects of intracoronary CD34\n              <jats:sup>+<\/jats:sup>\n              cell transplantation in dilated cardiomyopathy and the relationship between intramyocardial cell homing and clinical response.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Methods and Results:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>\n              Of 110 dilated cardiomyopathy patients, 55 were randomized to receive CD34\n              <jats:sup>+<\/jats:sup>\n              stem cell transplantation (SC group) and 55 received no cell therapy (controls). In the SC group, CD34\n              <jats:sup>+<\/jats:sup>\n              cells were mobilized by granulocyte colony-stimulating factor and collected via apheresis. Patients underwent myocardial scintigraphy and cells were injected in the artery supplying segments with the greatest perfusion defect. At baseline, 2 groups did not differ in age, sex, left ventricular ejection fraction, or N-terminal B-type natriuretic peptide levels. At 5 years, stem cell therapy was associated with increased left ventricular ejection fraction (from 24.3 \u00b1 6.5% to 30.0 \u00b1 5.1%;\n              <jats:italic>P<\/jats:italic>\n              =0.02), increased 6-minute walk distance (from 344 \u00b1 90 m to 477 \u00b1 130 m;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), and decreased N-terminal B-type natriuretic peptide (from 2322 \u00b1 1234 pg\/mL to 1011 \u00b1 893 pg\/mL;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.01). Left ventricular ejection fraction improvement was more significant in patients with higher myocardial homing of injected cells. During follow-up, 27 (25%) patients died and 9 (8%) underwent heart transplantation. Of the 27 deaths, 13 were attributed to pump failure and 14 were attributed to sudden cardiac death. Total mortality was lower in the SC group (14%) than in controls (35%;\n              <jats:italic>P<\/jats:italic>\n              =0.01). The same was true of pump failure (5% vs 18%;\n              <jats:italic>P<\/jats:italic>\n              =0.03), but not of sudden cardiac death (9% vs 16%;\n              <jats:italic>P<\/jats:italic>\n              =0.39).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Conclusions:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>Intracoronary stem cell transplantation may be associated with improved ventricular function, exercise tolerance, and long-term survival in patients with dilated cardiomyopathy. Higher intramyocardial homing is associated with better stem cell therapy response.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.112.276519","type":"journal-article","created":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T08:55:17Z","timestamp":1350118517000},"page":"165-173","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":245,"title":["Effects of Intracoronary CD34\n            <sup>+<\/sup>\n            Stem Cell Transplantation in Nonischemic Dilated Cardiomyopathy Patients"],"prefix":"10.1161","volume":"112","author":[{"given":"Bojan","family":"Vrtovec","sequence":"first","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Poglajen","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Lezaic","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matjaz","family":"Sever","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragoslav","family":"Domanovic","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Cernelc","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aljaz","family":"Socan","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Schrepfer","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Torre-Amione","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Haddad","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Wu","sequence":"additional","affiliation":[{"name":"From the Advanced Heart Failure and Transplantation Center (B.V, G.P.), Department of Nuclear Medicine (L.L., A.S.), and Department of Hematology, (M.S., P.C.), University Medical Centre Ljubljana, Ljubljana, Slovenia; National Blood Transfusion Institute, Ljubljana, Slovenia (D.D.); Department of Medicine, Division of Cardiology (B.V., S.S., F.H., J.C.W.) and Stanford Cardiovascular Institute (S.S., F.H., J.C.W.), Stanford University School of Medicine, Stanford, CA; and Methodist DeBakey Heart..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.016"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.051"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp220"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.108.843243"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.178913"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp374"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.01.095"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.11.92"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.09.050"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm011"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.109.855023"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.070"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.11.007"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-007-3045-5"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi162"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.6.2953"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01200-1"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0374"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.115"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/1074248407303139"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.07.008"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000091085.12422.19"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.111.969329"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(02)00324-5"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.500447"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.06.002"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000163546.27639.aa"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.108.777102"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.112.276519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T04:04:46Z","timestamp":1715573086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.112.276519"}},"subtitle":["5-Year Follow-Up"],"short-title":[],"issued":{"date-parts":[[2013,1,4]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,4]]}},"alternative-id":["10.1161\/CIRCRESAHA.112.276519"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.112.276519","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,4]]},"assertion":[{"value":"2012-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}