{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:15:47Z","timestamp":1789924547488,"version":"4.0.1"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2013,5,10]]},"abstract":"\n \n Rationale:<\/jats:underline>\n <\/jats:title>\n \n A chromosomal haplotype producing cardiac overexpression of dipeptidyl peptidase-like protein-6 (DPP6) causes familial idiopathic ventricular fibrillation. The molecular basis of transient outward current (\n I<\/jats:italic>\n to<\/jats:sub>\n ) in Purkinje fibers (PFs) is poorly understood. We hypothesized that DPP6 contributes to PF\n I<\/jats:italic>\n to<\/jats:sub>\n and that its overexpression might specifically alter PF\n I<\/jats:italic>\n to<\/jats:sub>\n properties and repolarization.\n <\/jats:p>\n <\/jats:sec>\n \n \n Objective:<\/jats:underline>\n <\/jats:title>\n \n To assess the potential role of DPP6 in PF\n I<\/jats:italic>\n to<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n \n Methods and Results:<\/jats:underline>\n <\/jats:title>\n \n Clinical data in 5 idiopathic ventricular fibrillation patients suggested arrhythmia origin in the PF-conducting system. PF and ventricular muscle\n I<\/jats:italic>\n to<\/jats:sub>\n had similar density, but PF\n I<\/jats:italic>\n to<\/jats:sub>\n differed from ventricular muscle in having tetraethylammonium sensitivity and slower recovery. DPP6 overexpression significantly increased, whereas DPP6 knockdown reduced,\n I<\/jats:italic>\n to<\/jats:sub>\n density and tetraethylammonium sensitivity in canine PF but not in ventricular muscle cells. The K\n +<\/jats:sup>\n -channel interacting \u03b2-subunit K\n +<\/jats:sup>\n -channel interacting protein type-2, essential for normal expression of\n I<\/jats:italic>\n to<\/jats:sub>\n in ventricular muscle, was weakly expressed in human PFs, whereas DPP6 and frequenin (neuronal calcium sensor-1) were enriched. Heterologous expression of Kv4.3 in Chinese hamster ovary cells produced small\n I<\/jats:italic>\n to<\/jats:sub>\n ;\n I<\/jats:italic>\n to<\/jats:sub>\n amplitude was greatly enhanced by coexpression with K\n +<\/jats:sup>\n -channel interacting protein type-2 or DPP6. Coexpression of DPP6 with Kv4.3 and K\n +<\/jats:sup>\n -channel interacting protein type-2 failed to alter\n I<\/jats:italic>\n to<\/jats:sub>\n compared with Kv4.3\/K\n +<\/jats:sup>\n -channel interacting protein type-2 alone, but DPP6 expression with Kv4.3 and neuronal calcium sensor-1 (to mimic PF\n I<\/jats:italic>\n to<\/jats:sub>\n composition) greatly enhanced\n I<\/jats:italic>\n to<\/jats:sub>\n compared with Kv4.3\/neuronal calcium sensor-1 and recapitulated characteristic PF kinetic\/pharmacological properties. A mathematical model of cardiac PF action potentials showed that\n I<\/jats:italic>\n to<\/jats:sub>\n enhancement can greatly accelerate PF repolarization.\n <\/jats:p>\n <\/jats:sec>\n \n \n Conclusions:<\/jats:underline>\n <\/jats:title>\n \n These results point to a previously unknown central role of DPP6 in PF\n I<\/jats:italic>\n to<\/jats:sub>\n , with DPP6 gain of function selectively enhancing PF current, and suggest that a DPP6-mediated PF early-repolarization syndrome might be a novel molecular paradigm for some forms of idiopathic ventricular fibrillation.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/circresaha.112.300227","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T04:54:43Z","timestamp":1364360083000},"page":"1310-1322","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":92,"title":["Unique Cardiac Purkinje Fiber Transient Outward Current \u03b2-Subunit Composition"],"prefix":"10.1161","volume":"112","author":[{"given":"Ling","family":"Xiao","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara T.","family":"Koopmann","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"\u00d6rd\u00f6g","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter G.","family":"Postema","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie O.","family":"Verkerk","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Iyer","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Sampson","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard J.J.","family":"Boink","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya A.","family":"Mamarbachi","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Varro","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Jordaens","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Res","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Kass","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur A.","family":"Wilde","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.R.","family":"Bezzina","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Nattel","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Montreal Heart Institute and Universit\u00e9 de Montr\u00e9al, Montreal, QC, Canada (L.X., B.O., M.A.M., S.N.); Department of Clinical and Experimental Cardiology (T.T.K., P.G.P., G.J., J.B., A.A.W., C.R.B.) and Department of Anatomy, Embryology and Physiology (A.O.V.), Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands; Department of Pharmacology, College of Physicians and Surgeons of Columbia University, New York, NY (V.I., K.J.S., R.S.K.);..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.976092"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.21.2334"},{"key":"e_1_3_5_4_2","first-page":"265","article-title":"Survivors of out-of-hospital cardiac arrest with apparently normal heart: need for definition and standardized clinical evaluation: Consensus Statement of the Joint Committees of the Unexplained Cardiac Arrest Registry of Europe and of the Idiopathic Ventricular Fibrillation Registry in the United States.","volume":"95","year":"1996","unstructured":"Survivors of out-of-hospital cardiac arrest with apparently normal heart: need for definition and standardized clinical evaluation: Consensus Statement of the Joint Committees of the Unexplained Cardiac Arrest Registry of Europe and of the Idiopathic Ventricular Fibrillation Registry in the United States. Circulation. 1996;95:265\u2013272.","journal-title":"Circulation"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.02.009"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.161620"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01185-6"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.087312"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200709912"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0001b.x"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.07.013"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2006"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-008-0060-y"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.2.H466"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00389.2002"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000039534.18114.d9"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.221168498"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201431200"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.06.017"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-003-2034-8"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.126714"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01288.2005"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth1104-163"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.135"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.187328"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.3.465"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000027564.55739.B1"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0119b.x"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2008.01230.x"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.062"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00716-6"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun248"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.110.221481"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/22.11.808"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.109.211292"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01170.2010"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc4201.097134"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.191809"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.107.748103"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.02.021"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.73.2.117"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(71)90074-5"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.12.017"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.05.020"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000592"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000057203.72435.C9"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.07.016"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-008-0389-1"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.1.197"},{"key":"e_1_3_5_50_2","first-page":"2246","article-title":"Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome.","volume":"118","author":"Brunner M","year":"2008","unstructured":"Brunner M, Peng X, Liu GX, et al.. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J Clin Invest. 2008;118:2246\u20132259.","journal-title":"J Clin Invest"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00673.2003"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12471-011-0102-8"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.1999.tb00183.x"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/circep.110.959619"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.112.300227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:54:03Z","timestamp":1715572443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.112.300227"}},"subtitle":["A Potential Molecular Link to Idiopathic Ventricular Fibrillation"],"short-title":[],"issued":{"date-parts":[[2013,5,10]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,5,10]]}},"alternative-id":["10.1161\/CIRCRESAHA.112.300227"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.112.300227","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,10]]},"assertion":[{"value":"2012-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}