{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:13:17Z","timestamp":1790622797201,"version":"4.1.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2013,7,5]]},"abstract":"<jats:p>Aortic stenosis is perhaps the most common of all valvular heart diseases in the developed nations of the world. Once primarily caused by rheumatic fever, the most common pathogenesis today is an active inflammatory process with some features that are similar to atherosclerosis. Because of this shift, the age at onset of severe obstruction has changed from the sixth decade 50 years ago to the eighth decade in most individuals today. The onset of symptoms remains a key determinant of outcome, although the later age at onset may make it difficult to discern if aortic stenosis or other age-related comorbidities is the cause of the symptoms. Once symptoms of aortic stenosis develop, life expectancy is shortened to \u22483 years unless the mechanical obstruction to left ventricular outflow is relieved by aortic valve replacement. Traditionally performed during cardiac surgery, aortic valve replacement now may be performed safely and effectively using transcatheter techniques, potentially revolutionizing the approach to this potentially fatal disease.<\/jats:p>","DOI":"10.1161\/circresaha.113.300156","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T20:23:16Z","timestamp":1373055796000},"page":"179-185","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":139,"title":["Introduction to Aortic Stenosis"],"prefix":"10.1161","volume":"113","author":[{"given":"Blase A.","family":"Carabello","sequence":"first","affiliation":[{"name":"From the Veterans Affairs Medical Center, Medical Service III, Houston, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001573-199603000-00002"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.2.844"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01821-5"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.08.036"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.057"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008313430903"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.11.1522"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043876"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804602"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1114\/1.122"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.38.1S5.V-61"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.09.075"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.105825"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-008-0017-1"},{"key":"e_1_3_3_16_2","first-page":"332","article-title":"Wall stress and patterns of hypertrophy in the human left ventricle.","volume":"53","author":"Grossman W","year":"1975","unstructured":"Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 1975;53:332\u2013341.","journal-title":"J Clin Invest"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.4.1099"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.59.4.679"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi290"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668681"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198707093170206"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90295-9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211253072202"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.71.6.1472"},{"key":"e_1_3_3_25_2","first-page":"333","article-title":"Myocardial characteristics of pressure overload hypertrophy. A structural and functional study.","volume":"51","author":"Breisch EA","year":"1984","unstructured":"Breisch EA, White FC, Bloor CM. Myocardial characteristics of pressure overload hypertrophy. A structural and functional study. Lab Invest. 1984;51:333\u2013342.","journal-title":"Lab Invest"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000074211.28917.31"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000074243.02378.80"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.10.013"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107281"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(51)90002-6"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107280"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.1.126"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(76)90021-9"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.6.1555"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh1701.095522"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704173361603"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000051865.66123.B7"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8097594"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc1202.105290"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.5.855"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90479-7"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.11.007"},{"key":"e_1_3_3_43_2","article-title":"Current management of calcific aortic stenosis.","author":"Lindman BR","unstructured":"Lindman BR, Bonow RO, Otto CM. Current management of calcific aortic stenosis. Circ Res Rev. In press.","journal-title":"Circ Res Rev"},{"key":"e_1_3_3_44_2","unstructured":"Online STS risk calculation. http:\/\/riskcalc.sts.org\/STSWebRiskCalc273\/de.aspx. Accessed February 3 2012."},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.495903"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)91317-3"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.9.2262"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.894170"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi250"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.4.381"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.02.075"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000126825.50903.18"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.021"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.11.024"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000025611.21140.34"},{"key":"e_1_3_3_56_2","volume-title":"Cardiology Pearls","author":"Carabello BA","year":"1994","unstructured":"Carabello BA, Ballard WL, Gazes PC, Sahn SA, Heffner JE. Cardiology Pearls. Philadelphia: Hanley and Belfus; 1994."},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs176"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000079171.43055.46"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200384"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.62.1.42"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.113.300156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:48:55Z","timestamp":1715572135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.113.300156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,5]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,7,5]]}},"alternative-id":["10.1161\/CIRCRESAHA.113.300156"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.113.300156","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,5]]},"assertion":[{"value":"2013-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}