{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:10:18Z","timestamp":1793747418151,"version":"4.6.1"},"reference-count":225,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2013,8,16]]},"abstract":"<jats:p>The network for cardiac fuel metabolism contains intricate sets of interacting pathways that result in both ATP-producing and non\u2013ATP-producing end points for each class of energy substrates. The most salient feature of the network is the metabolic flexibility demonstrated in response to various stimuli, including developmental changes and nutritional status. The heart is also capable of remodeling the metabolic pathways in chronic pathophysiological conditions, which results in modulations of myocardial energetics and contractile function. In a quest to understand the complexity of the cardiac metabolic network, pharmacological and genetic tools have been engaged to manipulate cardiac metabolism in a variety of research models. In concert, a host of therapeutic interventions have been tested clinically to target substrate preference, insulin sensitivity, and mitochondrial function. In addition, the contribution of cellular metabolism to growth, survival, and other signaling pathways through the production of metabolic intermediates has been increasingly noted. In this review, we provide an overview of the cardiac metabolic network and highlight alterations observed in cardiac pathologies as well as strategies used as metabolic therapies in heart failure. Lastly, the ability of metabolic derivatives to intersect growth and survival are also discussed.<\/jats:p>","DOI":"10.1161\/circresaha.113.302095","type":"journal-article","created":{"date-parts":[[2013,8,27]],"date-time":"2013-08-27T19:37:04Z","timestamp":1377632224000},"page":"603-616","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":804,"title":["Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes"],"prefix":"10.1161","volume":"113","author":[{"suffix":"Jr","given":"Stephen C.","family":"Kolwicz","sequence":"first","affiliation":[{"name":"From the Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine (S.C.K., S.P., R.T.), and Department of Medicine (S.P.), University of Washington School of Medicine, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneet","family":"Purohit","sequence":"additional","affiliation":[{"name":"From the Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine (S.C.K., S.P., R.T.), and Department of Medicine (S.P.), University of Washington School of Medicine, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tian","sequence":"additional","affiliation":[{"name":"From the Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine (S.C.K., S.P., R.T.), and Department of Medicine (S.P.), University of Washington School of Medicine, Seattle."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.36.030174.002213"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/26.9.817"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/26.8.721"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.3.377"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00788500"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2000.9510"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.100651"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.4.H1490"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1992.tb09265.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00332.2003"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0504"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.03.021"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.255505"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2580277.x"},{"key":"e_1_3_3_16_2","first-page":"H1862","article-title":"Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism.","volume":"267","author":"Collins-Nakai RL","year":"1994","unstructured":"Collins-Nakai RL, Noseworthy D, Lopaschuk GD. Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism. Am J Physiol. 1994;267:H1862\u2013H1871.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_17_2","volume-title":"Physiology of the Heart","author":"Katz AM","year":"2010","unstructured":"Katz AM. Physiology of the Heart. 5th ed. Philadelphia, PA: Wolters Kluwer Health\/Lippincott Williams & Wilkins Health; 2010.","edition":"5"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00093.2009"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.3.E420"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1139\/y95-725"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs426"},{"key":"e_1_3_3_22_2","first-page":"E772","article-title":"Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation.","volume":"277","author":"Goodwin GW","year":"1999","unstructured":"Goodwin GW, Taegtmeyer H. Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation. Am J Physiol. 1999;277:E772\u2013E777.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400347200"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1322"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.4.H1561"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74465-2"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2950061"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.324S"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.250S"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.06.007"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10268"},{"key":"e_1_3_3_32_2","first-page":"105","article-title":"PPAR expression and function during vertebrate development.","volume":"46","author":"Michalik L","year":"2002","unstructured":"Michalik L, Desvergne B, Dreyer C, Gavillet M, Laurini RN, Wahli W. PPAR expression and function during vertebrate development. Int J Dev Biol. 2002;46:105\u2013114.","journal-title":"Int J Dev Biol"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.08.006"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00526.2002"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1499107"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38151"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240038"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.489"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000112605.43318.ca"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00796517"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5321"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.44.26341"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.2.448"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.1.H75"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01012.2008"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1400com"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118876"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1058714"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.4.1074"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.09.015"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00285.2007"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2005.11.003"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.45.29530"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.676"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.16.7179-7187.2004"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00087-4"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.11.014"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M029991"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2007.11.006"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)92956-X"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00139.2005"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M011395"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.049817"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1123965"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2439"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06470-11"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9711-y"},{"key":"e_1_3_3_68_2","first-page":"H742","article-title":"Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts.","volume":"267","author":"Allard MF","year":"1994","unstructured":"Allard MF, Sch\u00f6nekess BO, Henning SL, English DR, Lopaschuk GD. Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts. Am J Physiol. 1994;267:H742\u2013H750.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199907000-00006"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103826200"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000144292.69599.0c"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00507.2001"},{"key":"e_1_3_3_73_2","first-page":"H1615","article-title":"Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine.","volume":"272","author":"El Alaoui-Talibi Z","year":"1997","unstructured":"El Alaoui-Talibi Z, Guendouz A, Moravec M, Moravec J. Control of oxidative metabolism in volume-overloaded rat hearts: effect of propionyl-L-carnitine. Am J Physiol. 1997;272:H1615\u2013H1624.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00856-1"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015332726303"},{"key":"e_1_3_3_76_2","first-page":"H741","article-title":"Influence of metabolic substrate on rat heart function and metabolism at different coronary flows.","volume":"261","author":"Burkhoff D","year":"1991","unstructured":"Burkhoff D, Weiss RG, Schulman SP, Kalil-Filho R, Wannenburg T, Gerstenblith G. Influence of metabolic substrate on rat heart function and metabolism at different coronary flows. Am J Physiol. 1991;261:H741\u2013H750.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.4.H1345"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000038231.68078.4b"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00437.2010"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.6.H2876"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00076.2008"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.691253"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.5.893"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1313"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn301"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.7.2190"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000137170.41939.d9"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.027"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00185-X"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000034049.61181.f3"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00599.2009"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57426"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.112.268128"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.108.189951"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.668665"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.04.003"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.05.003"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.112.969576"},{"key":"e_1_3_3_100_2","first-page":"251","article-title":"Proposed regulation of gene expression by glucose in rodent heart.","volume":"1","author":"Young ME","year":"2007","unstructured":"Young ME, Yan J, Razeghi P, Cooksey RC, Guthrie PH, Stepkowski SM, McClain DA, Tian R, Taegtmeyer H. Proposed regulation of gene expression by glucose in rodent heart. Gene Regul Syst Bio. 2007;1:251\u2013262.","journal-title":"Gene Regul Syst Bio"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164097"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179689"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.5.E1104"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0938"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.074"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0481"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0229-0"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0156-1"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.013"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0011"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10372"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.107.160457"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214080"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10947"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000264104.25265.b6"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409564102"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00883-5"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30566"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00422.2006"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00548.2011"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000165478.06813.58"},{"key":"e_1_3_3_122_2","volume-title":"Heart Physiology: From Cell to Circulation","author":"Opie LH","year":"2004","unstructured":"Opie LH. Heart Physiology: From Cell to Circulation. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004.","edition":"4"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.352"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.11.8836044"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3681"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0990027"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.551457"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.934059"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.02.004"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.7.2071"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000039326.87475.98"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000173896.32522.6e"},{"key":"e_1_3_3_133_2","first-page":"H1079","article-title":"Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts.","volume":"259","author":"McVeigh JJ","year":"1990","unstructured":"McVeigh JJ, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am J Physiol. 1990;259:H1079\u2013H1085.","journal-title":"Am J Physiol"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0524-6"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-010-0679-1"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.011387"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01957508"},{"key":"e_1_3_3_138_2","first-page":"154","article-title":"Dichloroacetate treatment for adult patients with mitochondrial disease.","volume":"43","author":"Oishi K","year":"2003","unstructured":"Oishi K, Yoshioka M, Ozawa R, Yamamoto T, Oya Y, Ogawa M, Kawai M. Dichloroacetate treatment for adult patients with mitochondrial disease. Rinsho Shinkeigaku. 2003;43:154\u2013161.","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.1089"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(88)91306-9"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.0000129255.19569.8f"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.642009"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00599.2005"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.645184"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00475.2010"},{"key":"e_1_3_3_146_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3180544540"},{"key":"e_1_3_3_147_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.107.092403"},{"key":"e_1_3_3_148_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.116871"},{"key":"e_1_3_3_149_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01014.2005"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp132"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00285.2005"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.217349"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00870.2007"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.02.019"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.0000248430.26229.0f"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.3.334"},{"key":"e_1_3_3_157_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.2043"},{"key":"e_1_3_3_158_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1110"},{"key":"e_1_3_3_159_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.10.1165"},{"key":"e_1_3_3_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00289-X"},{"key":"e_1_3_3_161_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066224"},{"key":"e_1_3_3_162_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02693930"},{"key":"e_1_3_3_163_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13505"},{"key":"e_1_3_3_164_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01269.2005"},{"key":"e_1_3_3_165_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05470.x"},{"key":"e_1_3_3_166_2","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1132"},{"key":"e_1_3_3_167_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000154542.13412.b1"},{"key":"e_1_3_3_168_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00347.2005"},{"key":"e_1_3_3_169_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2006.08.211"},{"key":"e_1_3_3_170_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000120505.91348.58"},{"key":"e_1_3_3_171_2","doi-asserted-by":"publisher","DOI":"10.2741\/2122"},{"key":"e_1_3_3_172_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346724"},{"key":"e_1_3_3_173_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q421"},{"key":"e_1_3_3_174_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3718com"},{"key":"e_1_3_3_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2008.10.042"},{"key":"e_1_3_3_176_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.109.214601"},{"key":"e_1_3_3_177_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI65268"},{"key":"e_1_3_3_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.075"},{"key":"e_1_3_3_179_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-09-0204"},{"key":"e_1_3_3_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.044"},{"key":"e_1_3_3_181_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402999200"},{"key":"e_1_3_3_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.12.008"},{"key":"e_1_3_3_183_2","doi-asserted-by":"publisher","DOI":"10.2459\/01.JCM.0000223257.09062.17"},{"key":"e_1_3_3_184_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.11.1338"},{"key":"e_1_3_3_185_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.038"},{"key":"e_1_3_3_186_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61239-8"},{"key":"e_1_3_3_187_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302119"},{"key":"e_1_3_3_188_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.001197"},{"key":"e_1_3_3_189_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1210558"},{"key":"e_1_3_3_190_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0921"},{"key":"e_1_3_3_191_2","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0202"},{"key":"e_1_3_3_192_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M800147-JLR200"},{"key":"e_1_3_3_193_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30335"},{"key":"e_1_3_3_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.05.004"},{"key":"e_1_3_3_195_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.004796"},{"key":"e_1_3_3_196_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.10.2413"},{"key":"e_1_3_3_197_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.08.016"},{"key":"e_1_3_3_198_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.04.002"},{"key":"e_1_3_3_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.03.002"},{"key":"e_1_3_3_200_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00808-5"},{"key":"e_1_3_3_201_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.8.1880"},{"key":"e_1_3_3_202_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021266"},{"key":"e_1_3_3_203_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.2.139"},{"key":"e_1_3_3_204_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.17.11647"},{"key":"e_1_3_3_205_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00582.2007"},{"key":"e_1_3_3_206_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.1.95"},{"key":"e_1_3_3_207_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.110742"},{"key":"e_1_3_3_208_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a011629"},{"key":"e_1_3_3_209_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.109769"},{"key":"e_1_3_3_210_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01021.2006"},{"key":"e_1_3_3_211_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037703"},{"key":"e_1_3_3_212_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq266"},{"key":"e_1_3_3_213_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0630588100"},{"key":"e_1_3_3_214_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010286200"},{"key":"e_1_3_3_215_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.6.3324"},{"key":"e_1_3_3_216_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37421-6"},{"key":"e_1_3_3_217_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.088"},{"key":"e_1_3_3_218_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63888"},{"key":"e_1_3_3_219_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.03.013"},{"key":"e_1_3_3_220_2","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjs055"},{"key":"e_1_3_3_221_2","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.111.244061"},{"key":"e_1_3_3_222_2","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2013.37.1.30"},{"key":"e_1_3_3_223_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9367-2"},{"key":"e_1_3_3_224_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2011.06.010"},{"key":"e_1_3_3_225_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.10.001"},{"key":"e_1_3_3_226_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-012-9350-y"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.113.302095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:52:27Z","timestamp":1715557947000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.113.302095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,16]]},"references-count":225,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,8,16]]}},"alternative-id":["10.1161\/CIRCRESAHA.113.302095"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.113.302095","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,16]]},"assertion":[{"value":"2013-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}