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Although randomized clinical trials have provided fairly convincing evidence that high-dose statins reduce the risk of recurrent cardiovascular events after ACS, there remain questions about how aggressively to reduce low-density lipoprotein cholesterol levels in ACS. Furthermore, no other lipid-related interventions have yet been proven to be effective in reducing major cardiovascular events after ACS. Here, we review the relationship of lipoproteins as biomarkers to cardiovascular risk after ACS, the evidence for lipid-targeted interventions, and the potential for novel therapeutic approaches in this arena.<\/jats:p>","DOI":"10.1161\/circresaha.114.302805","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T20:28:43Z","timestamp":1402000123000},"page":"1880-1889","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Lipoproteins as Biomarkers and Therapeutic Targets in the Setting of Acute Coronary Syndrome"],"prefix":"10.1161","volume":"114","author":[{"given":"Robert S.","family":"Rosenson","sequence":"first","affiliation":[{"name":"From the Department of Medicine (Cardiology), Icahn School of Medicine at Mount Sinai, New York, NY (R.S.R.); Cardiovascular Research Institute, Medstar Research Institute, Washington Hospital Center, DC (H.B.B.); and Departments of Medicine and Genetics and Cardiovascular Institute, Perelman School of Medicine of the University of Pennsylvania, Philadelphia (D.J.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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