{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:31:20Z","timestamp":1792290680574,"version":"4.4.0"},"reference-count":175,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2015,4,10]]},"abstract":"<jats:p>Thoracic aortic diseases that involve progressive enlargement, acute dissection, or rupture are influenced by the hemodynamic loads and mechanical properties of the wall. We have only limited understanding, however, of the mechanobiological processes that lead to these potentially lethal conditions. Homeostasis requires that intramural cells sense their local chemomechanical environment and establish, maintain, remodel, or repair the extracellular matrix to provide suitable compliance and yet sufficient strength. Proper sensing, in turn, necessitates both receptors that connect the extracellular matrix to intracellular actomyosin filaments and signaling molecules that transmit the related information to the nucleus. Thoracic aortic aneurysms and dissections are associated with poorly controlled hypertension and mutations in genes for extracellular matrix constituents, membrane receptors, contractile proteins, and associated signaling molecules. This grouping of factors suggests that these thoracic diseases result, in part, from dysfunctional mechanosensing and mechanoregulation of the extracellular matrix by the intramural cells, which leads to a compromised structural integrity of the wall. Thus, improved understanding of the mechanobiology of aortic cells could lead to new therapeutic strategies for thoracic aortic aneurysms and dissections.<\/jats:p>","DOI":"10.1161\/circresaha.114.304936","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T20:15:55Z","timestamp":1428610555000},"page":"1448-1461","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":409,"title":["Role of Mechanotransduction in Vascular Biology"],"prefix":"10.1161","volume":"116","author":[{"given":"Jay D.","family":"Humphrey","sequence":"first","affiliation":[{"name":"From the Departments of Biomedical Engineering (J.D.H., M.A.S.), Medicine (Cardiology) (M.A.S.), Cell Biology (M.A.S.), and Surgery (G.T.), Yale University, New Haven, CT; and Department of Internal Medicine, University of Texas Health Science Center, Houston (D.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (J.D.H., M.A.S.), Medicine (Cardiology) (M.A.S.), Cell Biology (M.A.S.), and Surgery (G.T.), Yale University, New Haven, CT; and Department of Internal Medicine, University of Texas Health Science Center, Houston (D.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Tellides","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (J.D.H., M.A.S.), Medicine (Cardiology) (M.A.S.), Cell Biology (M.A.S.), and Surgery (G.T.), Yale University, New Haven, CT; and Department of Internal Medicine, University of Texas Health Science Center, Houston (D.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Milewicz","sequence":"additional","affiliation":[{"name":"From the Departments of Biomedical Engineering (J.D.H., M.A.S.), Medicine (Cardiology) (M.A.S.), Cell Biology (M.A.S.), and Surgery (G.T.), Yale University, New Haven, CT; and Department of Internal Medicine, University of Texas Health Science Center, Houston (D.M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.8.080706.092303"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2009.09.008"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.08.084"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000483"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253026"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0185(20000101)258:1<1::AID-AR1>3.0.CO;2-7"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2008"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1583\/10-3374.1"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.12.003"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/43.11.7560894"},{"key":"e_1_3_4_12_2","first-page":"89","article-title":"Smooth muscle cell to elastic lamina connections in developing mouse aorta. Role in aortic medial organization.","volume":"68","author":"Davis EC.","year":"1993","unstructured":"Davis EC. Smooth muscle cell to elastic lamina connections in developing mouse aorta. Role in aortic medial organization. Lab Invest. 1993;68:89\u201399.","journal-title":"Lab Invest"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.20.1.99"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.3819"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.1.37"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.03.009"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511528200"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.653980"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910312107"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000108263.74520.15"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318158e981"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq356"},{"key":"e_1_3_4_23_2","first-page":"587","article-title":"Structural integration of the arterial wall. I. Relationships and attachments of medial smooth muscle cells in normally distended and hyperdistended aortas.","volume":"40","author":"Clark JM","year":"1979","unstructured":"Clark JM, Glagov S. Structural integration of the arterial wall. I. Relationships and attachments of medial smooth muscle cells in normally distended and hyperdistended aortas. Lab Invest. 1979;40:587\u2013602.","journal-title":"Lab Invest"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2011.0727"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/1081286514551495"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr195"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2009.02.008"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.191"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.1.451"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612054367544"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20060337"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-013-0928-x"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301624"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/30522"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-011-0287-4"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2012.0097"},{"key":"e_1_3_4_37_2","first-page":"568","article-title":"Mechanisms of arterial and aneurysmal tortuosity.","volume":"104","author":"Dobrin PB","year":"1988","unstructured":"Dobrin PB, Schwarcz TH, Baker WH. Mechanisms of arterial and aneurysmal tortuosity. Surgery. 1988;104:568\u2013571.","journal-title":"Surgery"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1159\/000342436"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.0397"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00223"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2262"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2012.05.027"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176009"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.2741\/3714"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005058"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.01.004"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.01.012"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-21576-1"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semvascsurg.2007.04.001"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2013.01.026"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-012-0876-x"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2009"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2008.05.002"},{"key":"e_1_3_4_54_2","first-page":"H851","article-title":"Arterial expansive remodeling induced by high flow rates.","volume":"272","author":"Driss AB","year":"1997","unstructured":"Driss AB, Benessian J, Pitevin P, Levy BI, Michel JB. Arterial expansive remodeling induced by high flow rates. Am J Physiol 1997;272:H851\u2013H858.","journal-title":"Am J Physiol"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.3.316"},{"key":"e_1_3_4_56_2","first-page":"H1247","article-title":"Perinatal aortic growth in lambs: relation to blood flow changes at birth.","volume":"259","author":"Langille BL","year":"1990","unstructured":"Langille BL, Brownlee RD, Adamson SL. Perinatal aortic growth in lambs: relation to blood flow changes at birth. Am J Physiol. 1990;259:H1247\u2013H1253.","journal-title":"Am J Physiol"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2012.05.025"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.99-0927com"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.157776"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01212.2010"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.261743"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.01.004"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00710.2001"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00432.2012"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.141275"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000202052.25238.68"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.06.010"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2008.11.011"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.990549"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.04.007"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.128820"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1159\/000025570"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.3317\/jraas.2000.007"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.3.319"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.08.128"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320358"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.3.741"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.4.C1083"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm809"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.06.023"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69942"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq224"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000476"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00287.2006"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.02.008"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.328"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.11.6.1660"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.843581"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)61229-1"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000225777.58488.f2"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.3.330"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005017"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn353"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.5.1046"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.96"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.01.002"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-007-9002-3"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3112"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.117.1.73"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199806)175:3<323::AID-JCP10>3.0.CO;2-6"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005066"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00552.x"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00023.2009"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.20037"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-008-9438-7"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10316"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1531"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1038\/35074532"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0235407100"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200506179"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1039\/c2ib20008b"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1890"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2013.05.006"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00399-6"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00299.2007"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.01.027"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2001.067001050.x"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303159200"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs135"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0402-e83"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0402-e65"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00818.2011"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007279700705"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.009"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1159\/000354222"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.03.020"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.97"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00032.2009"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206286200"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63464-5"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607581200"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314348110"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65334-5"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.8.710"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2005.06.008"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20546"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.11.005"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000099882.52647.E4"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162204"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.6.1499"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1038\/352337a0"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1392"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1511"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1721"},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.10.006"},{"key":"e_1_3_4_146_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.248161"},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2348"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.06.019"},{"key":"e_1_3_4_149_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.10.018"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.09.015"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.934"},{"key":"e_1_3_4_152_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115589"},{"key":"e_1_3_4_153_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007193230303"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68776-9"},{"key":"e_1_3_4_155_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31980"},{"key":"e_1_3_4_156_2","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.3.4.229"},{"key":"e_1_3_4_157_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000038109.84500.1e"},{"key":"e_1_3_4_158_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.149252"},{"key":"e_1_3_4_159_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.239343"},{"key":"e_1_3_4_160_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.209486"},{"key":"e_1_3_4_161_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69666"},{"key":"e_1_3_4_162_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005025"},{"key":"e_1_3_4_163_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a015909"},{"key":"e_1_3_4_164_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1124287"},{"key":"e_1_3_4_165_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35659"},{"key":"e_1_3_4_166_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000126897.41658.81"},{"key":"e_1_3_4_167_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20466"},{"key":"e_1_3_4_168_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.13.2659"},{"key":"e_1_3_4_169_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq230"},{"key":"e_1_3_4_170_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023411"},{"key":"e_1_3_4_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.08.056"},{"key":"e_1_3_4_172_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12436"},{"key":"e_1_3_4_173_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2014.01.001"},{"key":"e_1_3_4_174_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.20.2677"},{"key":"e_1_3_4_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2014.10.031"},{"key":"e_1_3_4_176_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71059"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.114.304936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:50:41Z","timestamp":1715572241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.114.304936"}},"subtitle":["Focus on Thoracic Aortic Aneurysms and Dissections"],"short-title":[],"issued":{"date-parts":[[2015,4,10]]},"references-count":175,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,4,10]]}},"alternative-id":["10.1161\/CIRCRESAHA.114.304936"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.114.304936","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,10]]},"assertion":[{"value":"2014-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}