{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:18:08Z","timestamp":1768699088798,"version":"3.49.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2014,9,26]]},"abstract":"<jats:sec>\n            <jats:title>\n              <jats:underline>Rationale:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>Ixmyelocel-T is associated with a wide range of biological activities relevant to tissue repair and regeneration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Objective:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>To evaluate the safety and efficacy of ixmyelocel-T in 2 prospective randomized phase 2A Trials administered via minithoracotomy or intramyocardial catheter injections in patients with dilated cardiomyopathy (DCM) stratified by ischemic or nonischemic status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Methods and Results:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>In IMPACT-DCM, patients were randomized to either ixmyelocel-T or standard-of-care control in a 3:1 ratio (n=39); ixmyelocel-T was administered intramyocardially via minithoracotomy. In Catheter-DCM, patients were randomized to either ixmyelocel-T or standard of care control in a 2:1 ratio (n=22); ixmyelocel-T was administered intramyocardially using the NOGA Myostar catheter. Only patients randomized to ixmyelocel-T underwent bone marrow aspiration and injections. In the 2 studies, a total of 61 patients were randomized, and 59 were treated or received standard of care. Fewer ischemic patients treated with ixmyelocel-T experienced a major adverse cardiovascular event during follow-up when compared with control patients. A similar benefit was not seen in the nonischemic patients. Heart failure exacerbation was the most common major adverse cardiovascular event. Ixmyelocel-T treatment was associated with improved New York Heart Association class, 6-minute walk distance, and Minnesota Living with Heart Failure Questionnaire scores in the ischemic population relative to control; a similar trend was not observed in the nonischemic population.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Conclusions:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>Intramyocardial injection with ixmyelocel-T reduces major adverse cardiovascular event and improves symptoms in patients with ischemic DCM but not in patients with nonischemic DCM.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.115.304554","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T04:21:18Z","timestamp":1408594878000},"page":"730-737","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":64,"title":["Safety and Efficacy of Ixmyelocel-T"],"prefix":"10.1161","volume":"115","author":[{"given":"Timothy D.","family":"Henry","sequence":"first","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay H.","family":"Traverse","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baron L.","family":"Hammon","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cara A.","family":"East","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bruckner","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann E.","family":"Remmers","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Recker","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bull","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit N.","family":"Patel","sequence":"additional","affiliation":[{"name":"From the Division of Cardiology, Cedars-Sinai Medical Center, The Heart Institute, Los Angeles, CA (T.D.H.); Division of Cardiology (T.D.H.) and Cardiovascular Division (J.H.T.), Minneapolis Heart Institute Foundation, MN; Division of Cardiothoracic Surgery (B.L.H.) and Clinical Cardiovascular Research Center (C.A.E.), Soltero Cardiovascular Research Center, Baylor University Medical Center, Dallas, TX; Division of Cardiovascular Surgery, DeBakey Heart and Vascular Center, The Methodist Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0b013e318291329a"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470994795.ch1"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","unstructured":"Yancy CW Jessup M Bozkurt B et al.. 2013 ACCF\/AHA Guideline for the Management of Heart Failure. 2013;62:e147\u2013239.","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000128596.49339.05"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.086074"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064669"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.03.021"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.418"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2007.12.002"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.047753"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.25321"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60195-0"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61590-0"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.245993"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.071"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt117"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt345"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt346"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.52"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.841"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.18.1837"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2008.02.017"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.02.030"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.2174\/157016113804547629"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt233"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.115.304554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:46:28Z","timestamp":1715571988000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.115.304554"}},"subtitle":["An Expanded, Autologous Multi-Cellular Therapy, in Dilated Cardiomyopathy"],"short-title":[],"issued":{"date-parts":[[2014,9,26]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,9,26]]}},"alternative-id":["10.1161\/CIRCRESAHA.115.304554"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.115.304554","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,26]]},"assertion":[{"value":"2014-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}