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In this review, we first provide an overview of how aging impacts the cardiac response to exercise, and the implications this has for functional capacity in older adults. We then review the underlying molecular mechanisms by which cardiac aging contributes to exercise intolerance, and conversely how exercise training can potentially modulate aging phenotypes in the heart. Finally, we highlight the potential use of these exercise models to complement models of disease in efforts to uncover new therapeutic targets to prevent or treat heart disease in the aging population.<\/jats:p>","DOI":"10.1161\/circresaha.115.305250","type":"journal-article","created":{"date-parts":[[2016,1,21]],"date-time":"2016-01-21T16:28:35Z","timestamp":1453393715000},"page":"279-295","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":150,"title":["The Role of Exercise in Cardiac Aging"],"prefix":"10.1161","volume":"118","author":[{"given":"Jason","family":"Roh","sequence":"first","affiliation":[{"name":"From the Cardiovascular Division (J. Roh, J. Rhee, V.C., A.R.) and Department of Anesthesiology, Critical Care, and Pain Medicine (J. 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