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The unmet need of controlling blood pressure in this population may be addressed, in part, by developing new drugs and devices\/procedures to treat hypertension and its comorbidities. In this Compendium Review, we discuss new drugs and interventional treatments that are undergoing preclinical or clinical testing for hypertension treatment. New drug classes, eg, inhibitors of vasopeptidases, aldosterone synthase and soluble epoxide hydrolase, agonists of natriuretic peptide A and vasoactive intestinal peptide receptor 2, and a novel mineralocorticoid receptor antagonist are in phase II\/III of development, while inhibitors of aminopeptidase A, dopamine \u03b2-hydroxylase, and the intestinal Na\n            <jats:sup>+<\/jats:sup>\n            \/H\n            <jats:sup>+<\/jats:sup>\n            exchanger 3, agonists of components of the angiotensin-converting enzyme 2\/angiotensin(1\u20137)\/Mas receptor axis and vaccines directed toward angiotensin II and its type 1 receptor are in phase I or preclinical development. The two main interventional approaches, transcatheter renal denervation and baroreflex activation therapy, are used in clinical practice for severe treatment resistant hypertension in some countries. Renal denervation is also being evaluated for treatment of various comorbidities, eg, chronic heart failure, cardiac arrhythmias and chronic renal failure. Novel interventional approaches in early development include carotid body ablation and arteriovenous fistula placement. Importantly, none of these novel drug or device treatments has been shown to prevent cardiovascular disease outcomes or death in hypertensive patients.\n          <\/jats:p>","DOI":"10.1161\/circresaha.116.303603","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T20:51:42Z","timestamp":1426193502000},"page":"1074-1095","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":250,"title":["New Approaches in the Treatment of Hypertension"],"prefix":"10.1161","volume":"116","author":[{"given":"Suzanne","family":"Oparil","sequence":"first","affiliation":[{"name":"From the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama (S.O.); and Department of Nephrology and Hypertension, University Hospital of the University Erlangen-N\u00fcrnberg, Germany (R.E.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[{"name":"From the Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama (S.O.); and Department of Nephrology and Hypertension, University Hospital of the University Erlangen-N\u00fcrnberg, Germany (R.E.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","unstructured":"Food and Drug Administration and the Department of Health and Human Services. 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