{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:10:42Z","timestamp":1793211042214,"version":"4.5.0"},"reference-count":144,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2015,3,13]]},"abstract":"<jats:p>Excess weight gain, especially when associated with increased visceral adiposity, is a major cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) hypertension. Increased renal tubular sodium reabsorption impairs pressure natriuresis and plays an important role in initiating obesity hypertension. The mediators of abnormal kidney function and increased blood pressure during development of obesity hypertension include (1) physical compression of the kidneys by fat in and around the kidneys, (2) activation of the renin\u2013angiotensin\u2013aldosterone system, and (3) increased sympathetic nervous system activity. Activation of the renin\u2013angiotensin\u2013aldosterone system is likely due, in part, to renal compression, as well as sympathetic nervous system activation. However, obesity also causes mineralocorticoid receptor activation independent of aldosterone or angiotensin II. The mechanisms for sympathetic nervous system activation in obesity have not been fully elucidated but may require leptin and activation of the brain melanocortin system. With prolonged obesity and development of target organ injury, especially renal injury, obesity-associated hypertension becomes more difficult to control, often requiring multiple antihypertensive drugs and treatment of other risk factors, including dyslipidemia, insulin resistance and diabetes mellitus, and inflammation. Unless effective antiobesity drugs are developed, the effect of obesity on hypertension and related cardiovascular, renal and metabolic disorders is likely to become even more important in the future as the prevalence of obesity continues to increase.<\/jats:p>","DOI":"10.1161\/circresaha.116.305697","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T16:51:42Z","timestamp":1426179102000},"page":"991-1006","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1263,"title":["Obesity-Induced Hypertension"],"prefix":"10.1161","volume":"116","author":[{"given":"John E.","family":"Hall","sequence":"first","affiliation":[{"name":"From the Departments of Physiology and Biophysics (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), Medicine (M.E.H.), Mississippi Center for Obesity Research (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), and Cardiovascular-Renal Research Center (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), University of Mississippi Medical Center, Jackson."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussara M.","family":"do Carmo","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Biophysics (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), Medicine (M.E.H.), Mississippi Center for Obesity Research (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), and Cardiovascular-Renal Research Center (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), University of Mississippi Medical Center, Jackson."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre A.","family":"da Silva","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Biophysics (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), Medicine (M.E.H.), Mississippi Center for Obesity Research (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), and Cardiovascular-Renal Research Center (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), University of Mississippi Medical Center, Jackson."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Biophysics (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), Medicine (M.E.H.), Mississippi Center for Obesity Research (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), and Cardiovascular-Renal Research Center (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), University of Mississippi Medical Center, Jackson."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Hall","sequence":"additional","affiliation":[{"name":"From the Departments of Physiology and Biophysics (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), Medicine (M.E.H.), Mississippi Center for Obesity Research (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), and Cardiovascular-Renal Research Center (J.E.H., J.M.d.C., A.A.d.S., Z.W., M.E.H.), University of Mississippi Medical Center, Jackson."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","unstructured":"Obesity and Overweight Fact Sheet No. 311. http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/. 2014. Accessed February 17 2015."},{"key":"e_1_3_5_3_2","unstructured":"U.S. Department of Health and Human Services - Centers for Disease Control and Prevention. http:\/\/www.cdc.gov\/obesity\/data\/. Accessed February 17 2015."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.732"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60844-8"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000052314.95497.78"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199412000-00018"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(87)90087-9"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(99)00123-5"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-1-200101020-00007"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200209000-00003"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2011"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJNRD.S39739"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.3.465"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.190413"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.22.3.292"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340010073016"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R110.113175"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000109749.11042.7c"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000090360.78539.CD"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0285"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(97)00075-7"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00791"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000112582.16683.EA"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20090289"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59701"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.64"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.89104000.x"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/01913120050176707"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00218.x"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.05.057"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.157370"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.175315"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.4.888"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07788.x"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E12-10-0774"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801871"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.44"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00796.2011"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110058"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001090000144"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.06.021"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.01.019"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00507.2004"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/6.12.1009"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.6.1047"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000084718.53355.69"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.1.140"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835b6c02"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011303"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011161"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000105624.68174.00"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.140988"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-042711-135929"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013121258"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.281.4.F639"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.119966"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.269.2.H629"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-013-0356-1"},{"key":"e_1_3_5_60_2","first-page":"R222","article-title":"Autonomic nervous system activity in weight gain and weight loss","volume":"269","author":"Arone LJ","year":"1995","unstructured":"Arone LJ, Mackintosh R, Rosenbaum M, Leibel RL, Hirsch J. Autonomic nervous system activity in weight gain and weight loss. Am J Physiol. 1995;269:R222\u2013R225.","journal-title":"Am J Physiol"},{"key":"e_1_3_5_61_2","first-page":"R1418","article-title":"Heart rate variability as a measure of autonomic function during weight change in humans.","volume":"261","author":"Hirsch J","year":"1991","unstructured":"Hirsch J, Leibel RL, Mackintosh R, Aguirre A. Heart rate variability as a measure of autonomic function during weight change in humans. Am J Physiol. 1991;261:R1418\u2013R1423.","journal-title":"Am J Physiol"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3423"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/hy0202.104398"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)01293-6"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.3.807"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00707.2003"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917080-00012"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.397"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.185074"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu048"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00633"},{"key":"e_1_3_5_72_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.03098"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402670"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60566-3"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.65.2.233"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.6.5.622"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0904179"},{"key":"e_1_3_5_78_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00194"},{"key":"e_1_3_5_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.201186"},{"key":"e_1_3_5_80_2","doi-asserted-by":"crossref","DOI":"10.1016\/0895-7061(96)81511-1","article-title":"Role of renal afferent nerves in obesity-induced hypertension.","volume":"9","author":"Zappe DH","year":"1996","unstructured":"Zappe DH, Capel WT, Keen HL, Shek EW, Brands MW, Hall JE. Role of renal afferent nerves in obesity-induced hypertension. Am J Hypertens. 1996;9:20A.","journal-title":"Am J Hypertens"},{"key":"e_1_3_5_81_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00061.2013"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1187"},{"key":"e_1_3_5_83_2","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32835d0c05"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1550-8528.1997.tb00561.x"},{"key":"e_1_3_5_85_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119532"},{"key":"e_1_3_5_86_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3009"},{"key":"e_1_3_5_87_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.670"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.409"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8341"},{"key":"e_1_3_5_90_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.853077"},{"key":"e_1_3_5_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2005.00468.x"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2006.0023"},{"key":"e_1_3_5_93_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00705"},{"key":"e_1_3_5_94_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00180.2013"},{"key":"e_1_3_5_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/35007534"},{"key":"e_1_3_5_96_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254827.59792.b2"},{"key":"e_1_3_5_97_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.240226"},{"key":"e_1_3_5_98_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.161349"},{"key":"e_1_3_5_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.124255"},{"key":"e_1_3_5_100_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02257.x"},{"key":"e_1_3_5_101_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00405"},{"key":"e_1_3_5_102_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328344280b"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03173-X"},{"key":"e_1_3_5_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1454"},{"key":"e_1_3_5_105_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.7.2012"},{"key":"e_1_3_5_106_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0303992101"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00020"},{"key":"e_1_3_5_108_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000048342.54392.40"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1161\/hyp.60.suppl_1.A27"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070594"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.177"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1071"},{"key":"e_1_3_5_113_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199917121-00026"},{"key":"e_1_3_5_114_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0040"},{"key":"e_1_3_5_115_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.10.5999"},{"key":"e_1_3_5_116_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0034"},{"key":"e_1_3_5_117_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.03.06.db05-1143"},{"key":"e_1_3_5_118_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1369"},{"key":"e_1_3_5_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.05.004"},{"key":"e_1_3_5_120_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9238"},{"key":"e_1_3_5_121_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000048194.97428.1A"},{"key":"e_1_3_5_122_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000111836.54204.93"},{"key":"e_1_3_5_123_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.100636"},{"key":"e_1_3_5_124_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000227966.36744.d9"},{"key":"e_1_3_5_125_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2010.02088.x"},{"key":"e_1_3_5_126_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803085"},{"key":"e_1_3_5_127_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00392.2011"},{"key":"e_1_3_5_128_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90867.2008"},{"key":"e_1_3_5_129_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00849.2010"},{"key":"e_1_3_5_130_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03999"},{"key":"e_1_3_5_131_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2297"},{"key":"e_1_3_5_132_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.010"},{"key":"e_1_3_5_133_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.067256"},{"key":"e_1_3_5_134_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.160671"},{"key":"e_1_3_5_135_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.12.022"},{"key":"e_1_3_5_136_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00518.2012"},{"key":"e_1_3_5_137_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0037"},{"key":"e_1_3_5_138_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2007.01610.x"},{"key":"e_1_3_5_139_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1184"},{"key":"e_1_3_5_140_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr574"},{"key":"e_1_3_5_141_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-1-200601030-00006"},{"key":"e_1_3_5_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2012.12.003"},{"key":"e_1_3_5_143_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.arrt.2003.10.007"},{"key":"e_1_3_5_144_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1261211"},{"key":"e_1_3_5_145_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2014.04.004"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.116.305697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T23:45:12Z","timestamp":1715557512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.116.305697"}},"subtitle":["Interaction of Neurohumoral and Renal Mechanisms"],"short-title":[],"issued":{"date-parts":[[2015,3,13]]},"references-count":144,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,3,13]]}},"alternative-id":["10.1161\/CIRCRESAHA.116.305697"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.116.305697","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,13]]},"assertion":[{"value":"2014-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}