{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:00:39Z","timestamp":1790283639643,"version":"4.1.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2017,1,20]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:underline>Rationale:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Objective:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>To identify additional AAA risk loci using data from all available genome-wide association studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Methods and Results:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10\u2009204 cases and 107\u2009766 controls, we identified 4 new AAA risk loci: 1q32.3 (\n                      <jats:italic>SMYD2<\/jats:italic>\n                      ), 13q12.11 (\n                      <jats:italic>LINC00540<\/jats:italic>\n                      ), 20q13.12 (near\n                      <jats:italic>PCIF1<\/jats:italic>\n                      \/\n                      <jats:italic>MMP9<\/jats:italic>\n                      \/\n                      <jats:italic>ZNF335<\/jats:italic>\n                      ), and 21q22.2 (\n                      <jats:italic>ERG<\/jats:italic>\n                      ). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified\n                      <jats:italic>ERG<\/jats:italic>\n                      ,\n                      <jats:italic>IL6R<\/jats:italic>\n                      , and\n                      <jats:italic>LDLR<\/jats:italic>\n                      as modifiers of\n                      <jats:italic>MMP9<\/jats:italic>\n                      , with a direct interaction between\n                      <jats:italic>ERG<\/jats:italic>\n                      and\n                      <jats:italic>MMP9<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Conclusions:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.116.308765","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T23:37:27Z","timestamp":1480462647000},"page":"341-353","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":205,"title":["Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci"],"prefix":"10.1161","volume":"120","author":[{"given":"Gregory T.","family":"Jones","sequence":"first","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Tromp","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Kuivaniemi","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solveig","family":"Gretarsdottir","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette F.","family":"Baas","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betti","family":"Giusti","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Strauss","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke N.G.","family":"van\u2018t Hof","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Webb","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Erdman","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylyn D.","family":"Ritchie","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Elmore","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Verma","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pendergrass","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iftikhar J.","family":"Kullo","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Ye","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy L.","family":"Peissig","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the 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Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane T.","family":"Smelser","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Crosslin","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariza","family":"de Andrade","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan J.","family":"Ryer","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the Appendix."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine A.","family":"McCarty","sequence":"additional","affiliation":[{"name":"For the author affiliations, please see the 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