{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:35:11Z","timestamp":1793921711864,"version":"4.8.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2016,10,28]]},"abstract":"<jats:sec>\n            <jats:title>\n              <jats:underline>Rationale:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically increases with advancing age in men. However, the molecular mechanisms by which aging predisposes individuals to AAAs remain unknown.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Objective:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>In this study, we investigated the role of SIRT1 (Sirtuin 1), a class III histone deacetylase, in AAA formation and the underlying mechanisms linking vascular senescence and inflammation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Methods and Results:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>\n              The expression and activity of SIRT1 were significantly decreased in human AAA samples. SIRT1 in vascular smooth muscle cells was remarkably downregulated in the suprarenal aortas of aged mice, in which AAAs induced by angiotensin II infusion were significantly elevated. Moreover, vascular smooth muscle cell\u2013specific knockout of SIRT1 accelerated angiotensin II\u2013induced formation and rupture of AAAs and AAA-related pathological changes, whereas vascular smooth muscle cell\u2013specific overexpression of SIRT1 suppressed angiotensin II\u2013induced AAA formation and progression in\n              <jats:italic>Apoe<\/jats:italic>\n              <jats:sup>\u2212<\/jats:sup>\n              <jats:sup>\/\u2212<\/jats:sup>\n              mice. Furthermore, the inhibitory effect of SIRT1 on AAA formation was also proved in a calcium chloride (CaCl\n              <jats:sub>2<\/jats:sub>\n              )\u2013induced AAA model. Mechanistically, the reduction of SIRT1 was shown to increase vascular cell senescence and upregulate p21 expression, as well as enhance vascular inflammation. Notably, inhibition of p21-dependent vascular cell senescence by SIRT1 blocked angiotensin II\u2013induced nuclear factor-\u03baB binding on the promoter of monocyte chemoattractant protein-1 and inhibited its expression.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Conclusions:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>These findings provide evidence that SIRT1 reduction links vascular senescence and inflammation to AAAs and that SIRT1 in vascular smooth muscle cells provides a therapeutic target for the prevention of AAA formation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.116.308895","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T03:38:26Z","timestamp":1474429106000},"page":"1076-1088","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":255,"title":["Age-Associated Sirtuin 1 Reduction in Vascular Smooth Muscle Links Vascular Senescence and Inflammation to Abdominal Aortic Aneurysm"],"prefix":"10.1161","volume":"119","author":[{"given":"Hou-Zao","family":"Chen","sequence":"first","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Fei","family":"Pei","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Xu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiang","family":"Tang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yan","family":"Fu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Fei","family":"Yan","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Man","family":"Wang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hui","family":"Zou","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Pei","family":"Liu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (H.-Z.C., F.W., P.G., J.-F.P., Y.L., T.-T.X., X.T., W.-Y.F., J.L., Y.-F.Y., X.-M.W., L.H., Z.-Q.Z., R.Z., D.-P.L.); and Division of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City (M.-H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66459-8"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.180"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.735274"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.03.006"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009118"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000048894.99865.02"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.261388"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1001"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0802917105"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.435107"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.237875"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1111-4"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07622"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002384"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn224"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq107"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.124404"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.215483"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12247"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1958"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15334"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2005.06.003"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000118013.72016.ea"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7818"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26498"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38308"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2711"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.626606"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000048892.83521.58"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2007.03.012"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.216739"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00527-X"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.03.007"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.039"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.09.002"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00657-10"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1934713100"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00524-4"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1335"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000238"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.116.308895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:28:52Z","timestamp":1715570932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.116.308895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,28]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10,28]]}},"alternative-id":["10.1161\/CIRCRESAHA.116.308895"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.116.308895","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,28]]},"assertion":[{"value":"2016-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}