{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:34:15Z","timestamp":1789587255053,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2017,2,17]]},"abstract":"<jats:sec>\n            <jats:title>\n              <jats:underline>Rationale<\/jats:underline>\n              :\n            <\/jats:title>\n            <jats:p>New therapies for refractory angina are needed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Objective<\/jats:underline>\n              :\n            <\/jats:title>\n            <jats:p>\n              Assessment of transendocardial delivery of bone marrow CD133\n              <jats:sup>+<\/jats:sup>\n              cells in patients with refractory angina.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Methods and Results<\/jats:underline>\n              :\n            <\/jats:title>\n            <jats:p>\n              Randomized, double-blinded, placebo-controlled trial enrolled 31 patients with recurrent Canadian Cardiovascular Society II\u2013IV angina, despite optimal medical therapy, \u22651 myocardial segment with inducible ischemia in Tc-99m SPECT who underwent bone marrow biopsy and were allocated to cells (n=16) or placebo (n=15). Primary end point was absolute change in myocardial ischemia by SPECT. Secondary end points were left ventricular function and volumes by magnetic resonance imaging and angina severity. After 4 months, there were no significant differences in extent of inducible ischemia between groups (summed difference score mean [\u00b1SD]: 2.60 [2.6] versus 3.63 [3.6],\n              <jats:italic>P<\/jats:italic>\n              =0.52; total perfusion deficit: 3.60 [3.6] versus 5.01 [4.3],\n              <jats:italic>P<\/jats:italic>\n              =0.32; absolute changes of summed difference score: \u22121.38 [5.2] versus \u22120.73 [1.9],\n              <jats:italic>P<\/jats:italic>\n              =0.65; and total perfusion deficit: \u22121.33 [3.3] versus \u22122.19 [6.6],\n              <jats:italic>P<\/jats:italic>\n              =0.65). There was a significant reduction of left ventricular volumes (end-systolic volume: \u22124.3 [11.3] versus 7.4 [11.8],\n              <jats:italic>P<\/jats:italic>\n              =0.02; end-diastolic volume: \u22129.1 [14.9] versus 7.4 [15.8],\n              <jats:italic>P<\/jats:italic>\n              =0.02) and no significant change of left ventricular ejection fraction in the cell group. There was no difference in number of patients showing improvement of \u22651 Canadian Cardiovascular Society class after 1 (41.7% versus 58.3%;\n              <jats:italic>P<\/jats:italic>\n              =0.68), 4 (50% versus 33.3%;\n              <jats:italic>P<\/jats:italic>\n              =0.63), 6 (70% versus 50.0%;\n              <jats:italic>P<\/jats:italic>\n              =0.42), and 12 months (55.6% versus 81.8%;\n              <jats:italic>P<\/jats:italic>\n              =0.33) and use of nitrates after 12 months.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Conclusion<\/jats:underline>\n              :\n            <\/jats:title>\n            <jats:p>\n              Transendocardial CD133\n              <jats:sup>+<\/jats:sup>\n              cell therapy was safe. Study was underpowered to conclusively validate the efficacy, but it did not show a significant reduction of myocardial ischemia and angina versus placebo.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Clinical Trial Registration<\/jats:underline>\n              :\n            <\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier: NCT01660581.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.116.309009","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T03:50:24Z","timestamp":1480564224000},"page":"670-680","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Effects of Transendocardial Delivery of Bone Marrow\u2013Derived CD133\n            <sup>+<\/sup>\n            Cells on Left Ventricle Perfusion and Function in Patients With Refractory Angina"],"prefix":"10.1161","volume":"120","author":[{"given":"Wojciech","family":"Wojakowski","sequence":"first","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Jadczyk","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Michalewska-W\u0142udarczyk","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Parma","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142aw","family":"Markiewicz","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Rychlik","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Kostkiewicz","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Gruszczy\u0144ska","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"B\u0142ach","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Dzier\u02d9zak-Miet\u0142a","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Wa\u0144ha","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Ciosek","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Ocha\u0142a","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Rzeszutko","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw","family":"Cybulski","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0141ukasz","family":"Partyka","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zasada","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"W\u0142udarczyk","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Dworowy","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wac\u0142aw","family":"Kuczmik","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Smolka","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Paw\u0142owski","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular Interventions (\u0141.R., W.Z.) and Department of Angiology (\u0141.P.), University..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Ocha\u0142a","sequence":"additional","affiliation":[{"name":"From the Third Division of Cardiology (W.W., T.J., A.M.-W., Z.P., W.R., A.B., W.W., J.C., B.O., W.C., W.W., S.D., G.S., T.P., A.O., M.T.), Department of Hematology and Bone Marrow Transplantation (M.M., M.D.-M.), and Division of Diagnostic Imaging (K.G.), Medical University of Silesia, Katowice, Poland; Department of Nuclear Medicine Hospital John Paul II, Krak\u00f3w, Poland (M.K.); 2nd Department of Cardiology and Cardiovascular 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