{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:52:17Z","timestamp":1793040737936,"version":"4.5.0"},"reference-count":165,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2017,9,15]]},"abstract":"<jats:p>Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of the large number of genes and alleles attributed to DCM, comprehensive genetic testing encompasses ever-increasing gene panels. Genetic diagnosis can help predict prognosis, especially with regard to arrhythmia risk for certain subtypes. Moreover, cascade genetic testing in family members can identify those who are at risk or with early stage disease, offering the opportunity for early intervention. This review will address diagnosis and management of DCM, including the role of genetic evaluation. We will also overview distinct genetic pathways linked to DCM and their pathogenetic mechanisms. Historically, cardiac morphology has been used to classify cardiomyopathy subtypes. Determining genetic variants is emerging as an additional adjunct to help further refine subtypes of DCM, especially where arrhythmia risk is increased, and ultimately contribute to clinical management.<\/jats:p>","DOI":"10.1161\/circresaha.116.309396","type":"journal-article","created":{"date-parts":[[2017,9,14]],"date-time":"2017-09-14T16:20:12Z","timestamp":1505406012000},"page":"731-748","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":732,"title":["Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"121","author":[{"given":"Elizabeth M.","family":"McNally","sequence":"first","affiliation":[{"name":"From the Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago IL (E.M.M.); and Cardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora (L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Mestroni","sequence":"additional","affiliation":[{"name":"From the Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago IL (E.M.M.); and Cardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora (L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm342"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174287"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000455"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.06.012"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.3.564"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.54.633.435"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90111-0"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90901-A"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.2.126"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000006996"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.54.2.153"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015092"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1517\/21678707.2015.1057498"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.105"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.06.022"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00434-8"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437913.98912.1d"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00172-2"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1998.1145"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2009.01.006"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.079"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.01.001"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.931220"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.929646"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.03.590"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4087"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2011.07.008"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01788-6"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-2-200507190-00009"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.114.002411"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-016-4498-1"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.11.010"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.049"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.971549"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2014.01.014"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1363"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11091882"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.05.017"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.04.015"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2016.07.001"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht210"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.186093"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm456"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808138"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003688"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004133421502"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002149"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0589-1"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.078"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.09.084"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.050"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.204"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.968"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1463"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.58.011706.144703"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.4145"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2016.06.005"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.214197"},{"key":"e_1_3_4_60_2","first-page":"751","article-title":"Incidence and predictors of sudden death, major conduction defects and sustained ventricular tachyarrhythmias in 1388 patients with myotonic dystrophy type 1.","volume":"38","author":"Wahbi K","year":"2017","unstructured":"Wahbi K, Babuty D, Probst V, et al.. Incidence and predictors of sudden death, major conduction defects and sustained ventricular tachyarrhythmias in 1388 patients with myotonic dystrophy type 1. Eur Heart J. 2017;38:751\u2013758.","journal-title":"Eur Heart J"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI62862"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.01.013"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.90"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000331"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110186"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000007"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2012.08.003"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70108"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000135591.37759.AF"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010134"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng815"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5458"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.112.962928"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.673"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3719"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu050"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1505517"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0208"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.000062"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2016.00021"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv253"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002645"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6ca62"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1086\/342380"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09406"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.200964"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/163564"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.07.038"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.01.026"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.006346"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R600033200"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.059"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E14-02-0733"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19448"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19670"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.204388"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003802"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003875"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970673"},{"key":"e_1_3_4_100_2","first-page":"1011.","article-title":"Phase 2 study of a797, an oral, selective p38 mitogen-activated protein kinase inhibitor, in patients with lamin a\/c-related dilated cardiomyopathy.","volume":"37","author":"MacRae C","year":"2016","unstructured":"MacRae C, Taylor MRG, Mestroni L, Moses JR, Ashley EA, Wheeler MT, Lakdawala NK, Hershberger RE, Ptaszynski M, Sandor V, Saunders ME, Oliver C, Lee PA, Judge DP. Phase 2 study of a797, an oral, selective p38 mitogen-activated protein kinase inhibitor, in patients with lamin a\/c-related dilated cardiomyopathy. Eur Heart J. 2016;37:1011.","journal-title":"Eur Heart J"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eut291"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510519103"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv127"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs119"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.016"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-015-0167-0"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7955"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw307"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1111\/his.12963"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.038"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2010.00198.x"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw192"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2693"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1362"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74523"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv468"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.309568"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.06.029"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.066092"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.779"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.243139"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84669"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-7192(02)00153-1"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.528281"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.10.2434"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9224"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2014.11.011"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2017.1271872"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2016.05.004"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.927"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.113.000578"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.1.115"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00243-06"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65738-0"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001000"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200622"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq507"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.052"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308830"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2013.16"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.211"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.127241"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.109.861955"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv727"},{"key":"e_1_3_4_145_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft013"},{"key":"e_1_3_4_146_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2016.00020"},{"key":"e_1_3_4_147_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.255"},{"key":"e_1_3_4_148_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.110.958918"},{"key":"e_1_3_4_149_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq093"},{"key":"e_1_3_4_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_3_4_151_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_3_4_152_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs257"},{"key":"e_1_3_4_153_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2014.10.003"},{"key":"e_1_3_4_154_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.134"},{"key":"e_1_3_4_155_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306687"},{"key":"e_1_3_4_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.05.011"},{"key":"e_1_3_4_157_2","first-page":"535","article-title":"Early arrhythmic events in idiopathic dilated cardiomyopathy.","volume":"2","author":"Losurdo P","year":"2016","unstructured":"Losurdo P, Stolfo D, Merlo M, Barbati G, Gobbo M, Gigli M, Ramani R, Pinamonti B, Zecchin M, Finocchiaro G, Mestroni L, Sinagra G. Early arrhythmic events in idiopathic dilated cardiomyopathy. JACC Clin EP. 2016;2:535\u2013543.","journal-title":"JACC Clin EP"},{"key":"e_1_3_4_158_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"e_1_3_4_159_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000056"},{"key":"e_1_3_4_160_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.058"},{"key":"e_1_3_4_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2016.06.008"},{"key":"e_1_3_4_162_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1175"},{"key":"e_1_3_4_163_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11739"},{"key":"e_1_3_4_164_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.449"},{"key":"e_1_3_4_165_2","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0288"},{"key":"e_1_3_4_166_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003552"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.116.309396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T03:27:20Z","timestamp":1738812440000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.116.309396"}},"subtitle":["Genetic Determinants and Mechanisms"],"short-title":[],"issued":{"date-parts":[[2017,9,15]]},"references-count":165,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,9,15]]}},"alternative-id":["10.1161\/CIRCRESAHA.116.309396"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.116.309396","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,15]]},"assertion":[{"value":"2017-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}