{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:32:23Z","timestamp":1793151143856,"version":"4.5.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2017,5,12]]},"abstract":"<jats:sec>\n            <jats:title>\n              <jats:underline>Rationale:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells and T-cell\u2013derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used to treat hypertension. However, the function of T-cell MR in blood pressure (BP) regulation has not been elucidated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Objective:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>We aim to determine the role of T-cell MR in BP regulation and to explore the mechanism.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Methods and Results:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>\n              Using T-cell MR knockout mouse in combination with angiotensin II\u2013induced hypertensive mouse model, we demonstrated that MR deficiency in T cells strikingly decreased both systolic and diastolic BP and attenuated renal and vascular damage. Flow cytometric analysis showed that T-cell MR knockout mitigated angiotensin II\u2013induced accumulation of interferon-gamma (IFN-\u03b3)\u2013producing T cells, particularly CD8\n              <jats:sup>+<\/jats:sup>\n              population, in both kidneys and aortas. Similarly, eplerenone attenuated angiotensin II\u2013induced elevation of BP and accumulation of IFN-\u03b3\u2013producing T cells in wild-type mice. In cultured CD8\n              <jats:sup>+<\/jats:sup>\n              T cells, T-cell MR knockout suppressed IFN-\u03b3 expression whereas T-cell MR overexpression and aldosterone both enhanced IFN-\u03b3 expression. At the molecular level, MR interacted with NFAT1 (nuclear factor of activated T-cells 1) and activator protein-1 in T cells. Finally, T-cell MR overexpressing mice manifested more elevated BP compared with control mice after angiotensin II infusion and such difference was abolished by IFN-\u03b3\u2013neutralizing antibodies.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Conclusions:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>MR may interact with NFAT1 and activator protein-1 to control IFN-\u03b3 in T cells and to regulate target organ damage and ultimately BP. Targeting MR in T cells specifically may be an effective novel approach for hypertension treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.116.310480","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T01:10:35Z","timestamp":1489626635000},"page":"1584-1597","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":134,"title":["T-Cell Mineralocorticoid Receptor Controls Blood Pressure by Regulating Interferon-Gamma"],"prefix":"10.1161","volume":"120","author":[{"given":"Xue-Nan","family":"Sun","sequence":"first","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Juan","family":"Du","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Ru","family":"Zeng","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jun","family":"Zheng","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-Chang","family":"Zhang","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deping","family":"Kong","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Lu","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-Xia","family":"Shen","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yi","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Du","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu","family":"Qin","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichun","family":"Hua","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyang","family":"Sun","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyong","family":"Yin","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., Z.Z...."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[{"name":"From the Laboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People\u2019s Hospital, School of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.-Z.D.), Shanghai Key Laboratory of Stomatology (X.-N.S., C.L., Y.L., L.-J.D., M.-R.Z., X.-J.Z., W.-C.Z., Y.L., S.S., Z.Z., S.-Z.D.), Department of Cardiology, Shanghai Chest Hospital (Y.Y., L.D., M.Q., X.L.), and Department of Oral and Maxillofacial-Head Neck Oncology, Ninth People\u2019s Hospital (S.S., 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