{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:50:32Z","timestamp":1791262232854,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2015,7,17]]},"abstract":"<jats:sec>\n            <jats:title>\n              <jats:underline>Rationale:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>After acute myocardial infarction (MI), delineating the area-at-risk (AAR) is crucial for measuring how much, if any, ischemic myocardium has been salvaged. T2-weighted MRI is promoted as an excellent method to delineate the AAR. However, the evidence supporting the validity of this method to measure the AAR is indirect, and it has never been validated with direct anatomic measurements.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Objective:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>To determine whether T2-weighted MRI delineates the AAR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Methods and Results:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>\n              Twenty-one canines and 24 patients with acute MI were studied. We compared bright-blood and black-blood T2-weighted MRI with images of the AAR and MI by histopathology in canines and with MI by in vivo delayed-enhancement MRI in canines and patients. Abnormal regions on MRI and pathology were compared by (a) quantitative measurement of the transmural-extent of the abnormality and (b) picture matching of contours. We found no relationship between the transmural-extent of T2-hyperintense regions and that of the AAR (bright-blood-T2:\n              <jats:italic>r<\/jats:italic>\n              =0.06,\n              <jats:italic>P<\/jats:italic>\n              =0.69; black-blood-T2:\n              <jats:italic>r<\/jats:italic>\n              =0.01,\n              <jats:italic>P<\/jats:italic>\n              =0.97). Instead, there was a strong correlation with that of infarction (bright-blood-T2:\n              <jats:italic>r<\/jats:italic>\n              =0.94,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001; black-blood-T2:\n              <jats:italic>r<\/jats:italic>\n              =0.95,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). Additionally, contour analysis demonstrated a fingerprint match of T2-hyperintense regions with the intricate contour of infarcted regions by delayed-enhancement MRI. Similarly, in patients there was a close correspondence between contours of T2-hyperintense and infarcted regions, and the transmural-extent of these regions were highly correlated (bright-blood-T2:\n              <jats:italic>r<\/jats:italic>\n              =0.82,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001; black-blood-T2:\n              <jats:italic>r<\/jats:italic>\n              =0.83,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>\n              <jats:underline>Conclusion:<\/jats:underline>\n            <\/jats:title>\n            <jats:p>T2-weighted MRI does not depict the AAR. Accordingly, T2-weighted MRI should not be used to measure myocardial salvage, either to inform patient management decisions or to evaluate novel therapies for acute MI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.117.305771","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T03:05:52Z","timestamp":1431572752000},"page":"254-265","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":104,"title":["Relationship of T2-Weighted MRI Myocardial Hyperintensity and the Ischemic Area-At-Risk"],"prefix":"10.1161","volume":"117","author":[{"given":"Han W.","family":"Kim","sequence":"first","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowie","family":"Van Assche","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Jennings","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Benjamin","family":"Wince","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph J.","family":"Jensen","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang G.","family":"Rehwald","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Wendell","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubna","family":"Bhatti","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deneen M.","family":"Spatz","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele A.","family":"Parker","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Jenista","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Klem","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Lisa C.","family":"Crowley","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enn-Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Judd","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Duke Cardiovascular Magnetic Resonance Center (DCMRC), Department of Medicine, Division of Cardiology (H.W.K., L.V.A., W.B.W., C.J.J., W.G.R., D.C.W., L.B., D.M.S., M.A.P., E.R.J., I.K., A.L.C.C., E.-L.C.), Department of Pathology (R.B.J.), and Department of Radiology (R.M.J., R.J.K.), Duke University Medical Center, Durham, NC; and Siemens Healthcare, Chicago, IL (W.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"633","article-title":"The \u201cwavefront phenomenon\u201d of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow.","volume":"40","author":"Reimer KA","year":"1979","unstructured":"Reimer KA, Jennings RB. The \u201cwavefront phenomenon\u201d of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest. 1979;40:633\u2013644.","journal-title":"Lab Invest"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111769"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60916-7"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.28"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-13-13"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.140"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq481"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-010-9714-0"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq409"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.816512"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.965343"},{"key":"e_1_3_4_13_2","unstructured":"Clinicaltrials.Gov. http:\/\/clinicaltrials.gov\/. Accessed May 29 2013. Search terms with Boolean operators: ((T2 OR salvage) AND (magnetic OR mri OR cmr) AND (heart OR myocardium)) OR (magnetic AND myocardial infarction). Entries were examined before inclusion."},{"key":"e_1_3_4_14_2","unstructured":"Current Controlled Trials. http:\/\/www.controlled-trials.com\/. Accessed May 29 2013. Search terms with Boolean operators: ((T2 OR salvage) AND (magnetic OR mri OR cmr) AND (heart OR myocardium)) OR (magnetic AND myocardial infarction). Entries were examined before inclusion."},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.124"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.576025"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.019"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.111.963421"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80283-1"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.56.2.262"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-011-0214-8"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.004"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.01.016"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.19.1992"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.2.330"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00958-X"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.5.786"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67861-0"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1280"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu331"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.048"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21215"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2010.09.023"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21490"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"e_1_3_4_36_2","first-page":"1198","article-title":"The angiographic definitions of the bypass angioplasty revascularization investigation.","volume":"3","author":"Alderman EM","year":"1992","unstructured":"Alderman EM, Stadius ML. The angiographic definitions of the bypass angioplasty revascularization investigation. Coron Artery Dis. 1992;3:1198\u20131207.","journal-title":"Coron Artery Dis"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.900761"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.11.018"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.059"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2233011181"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.64.3.526"},{"key":"e_1_3_4_42_2","first-page":"381","article-title":"Effect of a transient period of ischemia on myocardial cells. I. Effects on cell volume regulation.","volume":"74","author":"Whalen DA","year":"1974","unstructured":"Whalen DA, Hamilton DG, Ganote CE, Jennings RB. Effect of a transient period of ischemia on myocardial cells. I. Effects on cell volume regulation. Am J Pathol. 1974;74:381\u2013397.","journal-title":"Am J Pathol"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1159\/000418813"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2004.1499"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.992"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1343"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2013.04.022"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.117.305771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:40:45Z","timestamp":1715571645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.117.305771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,17]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,7,17]]}},"alternative-id":["10.1161\/CIRCRESAHA.117.305771"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.117.305771","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,17]]},"assertion":[{"value":"2015-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}