{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:28:44Z","timestamp":1787588924010,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2018,5,11]]},"abstract":"<jats:sec>\n                    <jats:title>\n                      <jats:underline>Rationale:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Increasing evidence indicates the presence of lncRNAs in various cell types.\n                      <jats:italic>Airn<\/jats:italic>\n                      is an imprinting gene transcribed from the paternal chromosome. It is in antisense orientation to the imprinted, but maternally derived,\n                      <jats:italic>Igf2r<\/jats:italic>\n                      gene, on which\n                      <jats:italic>Airn<\/jats:italic>\n                      exerts its regulation in\n                      <jats:italic>cis<\/jats:italic>\n                      . Although\n                      <jats:italic>Airn<\/jats:italic>\n                      is highly expressed in the heart, functions aside from imprinting remain unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Objective:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Here, we studied the functions of\n                      <jats:italic>Airn<\/jats:italic>\n                      in the heart, especially cardiomyocytes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Methods and Results:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Silencing of\n                      <jats:italic>Airn<\/jats:italic>\n                      via siRNAs augmented cell death, vulnerability to cellular stress, and reduced cell migration. To find the cause of such phenotypes, the potential binding partners of\n                      <jats:italic>Airn<\/jats:italic>\n                      were identified via RNA pull-down followed by mass spectrometry, which indicated Igf2bp2 (insulin-like growth factor 2 mRNA-binding protein 2) and Rpa1 (replication protein A1) as potential binding partners. Further experiments showed that\n                      <jats:italic>Airn<\/jats:italic>\n                      binds to Igf2bp2 to control the translation of several genes. Moreover, silencing of\n                      <jats:italic>Airn<\/jats:italic>\n                      caused less binding of Igf2bp2 to other mRNAs and reduced translation of Igf2bp2 protein.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:underline>Conclusions:<\/jats:underline>\n                    <\/jats:title>\n                    <jats:p>\n                      Our study uncovers a new function of\n                      <jats:italic>Airn<\/jats:italic>\n                      and demonstrates that\n                      <jats:italic>Airn<\/jats:italic>\n                      is important for the physiology of cardiomyocytes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circresaha.117.312215","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T05:15:27Z","timestamp":1519622127000},"page":"1347-1353","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["<i>Airn<\/i>\n                    Regulates Igf2bp2 Translation in Cardiomyocytes"],"prefix":"10.1161","volume":"122","author":[{"given":"Mohammed Rabiul","family":"Hosen","sequence":"first","affiliation":[{"name":"From the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Department of Biosciences (M.R.H., G.M., T.W., Y.P.)"},{"name":"German Center for Cardiovascular Research, Partner side Rhein-Main, Frankfurt (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Militello","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Department of Biosciences (M.R.H., G.M., T.W., Y.P.)"},{"name":"German Center for Cardiovascular Research, Partner side Rhein-Main, Frankfurt (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Cardiovascular Innovation Institute (G.M., T.W., S.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Weirick","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Department of Biosciences (M.R.H., G.M., T.W., Y.P.)"},{"name":"German Center for Cardiovascular Research, Partner side Rhein-Main, Frankfurt (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Cardiovascular Innovation Institute (G.M., T.W., S.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Ponomareva","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Department of Biosciences (M.R.H., G.M., T.W., Y.P.)"},{"name":"German Center for Cardiovascular Research, Partner side Rhein-Main, Frankfurt (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujith","family":"Dassanayaka","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"German Center for Cardiovascular Research, Partner side Rhein-Main, Frankfurt (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"Joseph B.","family":"Moore","sequence":"additional","affiliation":[{"name":"From the Institute of Cardiovascular Regeneration, Centre for Molecular Medicine (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Division of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center (S.D., J.B.M., M.W., S.P.J.), University of Louisville, KY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"D\u00f6ring","sequence":"additional","affiliation":[{"name":"Dr Senckenberg Institute of Pathology, Goethe University Frankfurt, Germany (C.D.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Wysoczynski","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center (S.D., J.B.M., M.W., S.P.J.), University of Louisville, KY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center (S.D., J.B.M., M.W., S.P.J.), University of Louisville, KY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dimmeler","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Institute of Molecular Cardiology, Diabetes and Obesity Center (S.D., J.B.M., M.W., S.P.J.), University of Louisville, KY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizuka","family":"Uchida","sequence":"additional","affiliation":[{"name":"German Center for Cardiovascular Research, Partner side Rhein-Main, Frankfurt (M.R.H., G.M., T.W., Y.P., S.D., S.U.)"},{"name":"Cardiovascular Innovation Institute (G.M., T.W., S.U.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.302521"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7262"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/39631"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601245"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.206201"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-015-0003-y"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.088849"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04520-z"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.2979"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks877"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr1110"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.07.014"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.578682"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163802"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.3783805"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.10.014"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11045"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.079756"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1314"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.132159.111"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.303265"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.09.949"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310624"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2008.08.004"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1677\/JME-09-0016"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00665-10"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.10.019"}],"container-title":["Circulation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCRESAHA.117.312215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:03:09Z","timestamp":1715562189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCRESAHA.117.312215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,11]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,5,11]]}},"alternative-id":["10.1161\/CIRCRESAHA.117.312215"],"URL":"https:\/\/doi.org\/10.1161\/circresaha.117.312215","relation":{},"ISSN":["0009-7330","1524-4571"],"issn-type":[{"value":"0009-7330","type":"print"},{"value":"1524-4571","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,11]]},"assertion":[{"value":"2017-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}