{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:53:06Z","timestamp":1793692386242,"version":"4.5.1"},"reference-count":111,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2018,8,17]]},"abstract":"<jats:p>\n                    Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S)\u2014a potent gaseous signaling molecule\u2014has emerged as a critical regulator of cardiovascular homeostasis. H\n                    <jats:sub>2<\/jats:sub>\n                    S is produced enzymatically by 3 constitutively active endogenous enzymes in all mammalian species. Within the past 2 decades, studies administering H\n                    <jats:sub>2<\/jats:sub>\n                    S-donating agents and the genetic manipulation of H\n                    <jats:sub>2<\/jats:sub>\n                    S-producing enzymes have revealed multiple beneficial effects of H\n                    <jats:sub>2<\/jats:sub>\n                    S, including vasodilation, activation of antiapoptotic and antioxidant pathways, and anti-inflammatory effects. More recently, the heightened enthusiasm in this field has shifted to the development of novel H\n                    <jats:sub>2<\/jats:sub>\n                    S-donating agents that exert favorable pharmacological profiles. This has led to the discovery of novel H\n                    <jats:sub>2<\/jats:sub>\n                    S-mediated signaling pathways. This review will discuss recently developed H\n                    <jats:sub>2<\/jats:sub>\n                    S therapeutics, introduce signaling pathways that are influenced by H\n                    <jats:sub>2<\/jats:sub>\n                    S-dependent sulfhydration, and explore the dual-protective effect of H\n                    <jats:sub>2<\/jats:sub>\n                    S in cardiorenal syndrome.\n                  <\/jats:p>","DOI":"10.1161\/circresaha.118.311134","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T03:00:23Z","timestamp":1536894023000},"page":"590-600","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":145,"title":["Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease"],"prefix":"10.1161","volume":"123","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[{"name":"From the Cardiovascular Center of Excellence and Department of Pharmacology, LSU Health Science Center, New Orleans, LA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Polhemus","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center of Excellence and Department of Pharmacology, LSU Health Science Center, New Orleans, LA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lefer","sequence":"additional","affiliation":[{"name":"From the Cardiovascular Center of Excellence and Department of Pharmacology, LSU Health Science Center, New Orleans, 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