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For abdominal aortic aneurysms, genetic associations have been identified, which provide insight on the molecular pathogenesis but cannot be used clinically yet to identify individuals at risk for abdominal aortic aneurysms. This compendium will discuss our current understanding of the genetic basis of thoracic aortic disease and abdominal aortic aneurysm disease. Although both diseases share several pathogenic similarities, including proteolytic elastic tissue degeneration and smooth muscle dysfunction, they also have several distinct differences, including population prevalence and modes of inheritance.<\/jats:p>","DOI":"10.1161\/circresaha.118.312436","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T19:00:52Z","timestamp":1550170852000},"page":"588-606","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":433,"title":["Genetics of Thoracic and Abdominal Aortic Diseases"],"prefix":"10.1161","volume":"124","author":[{"given":"Am\u00e9lie","family":"Pinard","sequence":"first","affiliation":[{"name":"From the Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School; University of Texas Health Science Center at Houston (A.P., D.M.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, New Zealand (G.T.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Milewicz","sequence":"additional","affiliation":[{"name":"From the Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School; University of Texas Health Science Center at Houston (A.P., D.M.M.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"1","article-title":"Deaths: final data for 1999.","volume":"49","author":"Hoyert DL","year":"2001","unstructured":"Hoyert, DL, Arias, E, Smith, BL, Murphy, SL, Kochanek, KD. 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