{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:57:09Z","timestamp":1791943029246,"version":"4.3.4"},"reference-count":80,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2019,1,4]]},"abstract":"<jats:p>In a somewhat narrow diagnostic lens, Alzheimer disease (AD) has been considered a brain-specific disease characterized by the presence of A\u03b2 (\u03b2-amyloid) plaques and tau neural fibrillary tangles and neural inflammation; these pathologies lead to neuronal death and consequently clinical symptoms, such as memory loss, confusion, and impaired cognitive function. However, for decades, researchers have noticed a link between various cardiovascular abnormalities and AD\u2014such as heart failure, coronary artery disease, atrial fibrillation, and vasculopathy. A considerable volume of work has pointed at this head to heart connection, focusing mainly on associations between cerebral hypoperfusion and neuronal degradation. However, new evidence of a possible systemic or metastatic profile to AD calls for further analysis of this connection. A\u03b2 aggregations\u2014biochemically and structurally akin to those found in the typical AD pathology\u2014are now known to be present in the hearts of individuals with idiopathic dilated cardiomyopathy, as well as the hearts of patients with AD. These findings suggest a potential systemic profile of proteinopathies and a new hypothesis for the link between peripheral and central symptoms of heart failure and AD. Herein, we provide an overview of the cardiovascular links to Alzheimer disease.<\/jats:p>","DOI":"10.1161\/circresaha.118.313563","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T19:00:26Z","timestamp":1546542026000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":178,"title":["Getting to the Heart of Alzheimer Disease"],"prefix":"10.1161","volume":"124","author":[{"given":"Joshua M.","family":"Tublin","sequence":"first","affiliation":[{"name":"From the College of Nursing (J.M.T., J.M.A., L.E.W.), The Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Adelstein","sequence":"additional","affiliation":[{"name":"From the College of Nursing (J.M.T., J.M.A., L.E.W.), The Ohio State University, Columbus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"del 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