{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:48:01Z","timestamp":1778802481387,"version":"3.51.4"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circulation Research"],"published-print":{"date-parts":[[2019,12,6]]},"abstract":"<jats:sec>\n            <jats:title>Rationale:<\/jats:title>\n            <jats:p>\u03b1CGRP (\u03b1 calcitonin gene-related peptide), one of the strongest vasodilators, is cardioprotective in hypertension by reducing the elevated blood pressure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>However, we hypothesize that endogenous, physical activity\u2013induced \u03b1CGRP has blood pressure\u2013independent cardioprotective effects in chronic hypertension.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results:<\/jats:title>\n            <jats:p>\n              Chronically hypertensive (one-kidney-one-clip surgery) wild-type and \u03b1CGRP\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              sedentary or voluntary wheel running mice were treated with vehicle, \u03b1CGRP, or the \u03b1CGRP receptor antagonist CGRP8-37. Cardiac function and myocardial phenotype were evaluated echocardiographically and by molecular, cellular, and histological analysis, respectively. Blood pressure was similar among all hypertensive experimental groups. Endogenous \u03b1CGRP limited pathological remodeling and heart failure in sedentary, chronically hypertensive wild-type mice. In these mice, voluntary wheel running significantly improved myocardial phenotype and function, which was abolished by CGRP8-37 treatment. In \u03b1CGRP\n              <jats:sup>\u2212\/\u2212<\/jats:sup>\n              mice, \u03b1CGRP treatment, in contrast to voluntary wheel running, improved myocardial phenotype and function. Specific inhibition of proliferation and myofibroblast differentiation of primary, murine cardiac fibroblasts by \u03b1CGRP suggests involvement of these cells in \u03b1CGRP-dependent blunting of pathological cardiac remodeling.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Endogenous, physical activity\u2013induced \u03b1CGRP has blood pressure\u2013independent cardioprotective effects and is crucial for maintaining cardiac function in chronic hypertension. Consequently, inhibiting endogenous \u03b1CGRP signaling, as currently approved for migraine prophylaxis, could endanger patients with hypertension.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circresaha.119.315429","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T09:04:22Z","timestamp":1572512662000},"page":"1124-1140","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Blood Pressure Normalization\u2013Independent Cardioprotective Effects of Endogenous, Physical Activity\u2013Induced \u03b1CGRP (\u03b1 Calcitonin Gene-Related Peptide) in Chronically Hypertensive Mice"],"prefix":"10.1161","volume":"125","author":[{"given":"Tom","family":"Skaria","sequence":"first","affiliation":[{"name":"From the Institute of Veterinary Physiology (T.S., O.V., M.G., J.V.), Vetsuisse Faculty, University of Z\u00fcrich, Switzerland"},{"name":"Z\u00fcrich Center for Integrative Human 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